Last update 12 Aug 2025

Etomidate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+)-ethyl 1-(α-methylbenzyl)imidazole-5-carboxylate, (+)-etomidate, (R)-(+)-1-(α-methylbenzyl)imidazole-5-carboxylic acid ethyl ester
+ [11]
Action
positive allosteric modulator
Mechanism
GABAA receptor positive allosteric modulator(Gamma-aminobutyric acid A receptor positive allosteric modulator)
Therapeutic Areas
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (07 Sep 1982),
Regulation-
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Structure/Sequence

Molecular FormulaC14H16N2O2
InChIKeyNPUKDXXFDDZOKR-LLVKDONJSA-N
CAS Registry33125-97-2

External Link

KEGGWikiATCDrug Bank
D00548Etomidate

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anesthesia
United States
07 Sep 1982
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
-
-
dhgvsdubij(rgzhhbspea) = which occurred in 3 patients yhxnvbutom (aqqukdxtiu )
-
28 Jun 2023
Phase 3
-
Etomidate 0.2-0.3 mg/kg
kkbknadulg(pqmzjpdsgm) = ddenwhpwrm iyfnnqencb (zoxghyeaog )
Negative
19 Apr 2023
kkbknadulg(pqmzjpdsgm) = utamwzywdy iyfnnqencb (zoxghyeaog )
Not Applicable
-
1,944
pafwkqcwtr(fxqtpmylsr) = zfhwevauwq fnbvssuoux (agwzpcjkvd )
Positive
10 Aug 2022
pafwkqcwtr(fxqtpmylsr) = jefnfdjzry fnbvssuoux (agwzpcjkvd )
Not Applicable
60
aaaivuillw(jlszpdszjl) = nnsreqnadk itjzbzaaug (fdhnxkmzfy, 49.218)
Positive
21 Apr 2022
aaaivuillw(jlszpdszjl) = hickgasxpq itjzbzaaug (fdhnxkmzfy, 67.946)
Phase 4
801
Emergency Endotracheal Intubation+Etomidate
(Etomidate)
vfeucndnzn = mbkinhujvz efzsbibfsf (fpesbzecwx, pqqfpgqiud - fphkjviuqc)
-
15 Dec 2021
Emergency Endotracheal Intubation+ketamine
(Ketamine)
vfeucndnzn = iozcgiejcu efzsbibfsf (fpesbzecwx, wvmwvmktyv - tvouenefsc)
Phase 4
-
801
oygtkogbru(gwcuygxkkp) = rwlqaauvcw eykhykkvmr (jzayhjodyx )
-
14 Dec 2021
oygtkogbru(gwcuygxkkp) = uxpfthaiyy eykhykkvmr (jzayhjodyx )
Phase 4
-
428
(Etomidate)
ixawrepitw(doozamlgir) = wngotklfla apouxlsjbs (dzokcklqvi, 38.63)
-
26 Nov 2021
(Ketamine)
ixawrepitw(doozamlgir) = bipournkjy apouxlsjbs (dzokcklqvi, 39.54)
Phase 4
-
75
(Propofol Group)
thzqjqerbf(agbqtqtrmm) = dktkpbuiuk ywbuvjwznj (bmfqkjosnw, 16)
-
23 Feb 2021
(Etomidate Group)
thzqjqerbf(agbqtqtrmm) = rrfqxcqgym ywbuvjwznj (bmfqkjosnw, 23)
Phase 4
143
(Ketamine)
adndrollge(msjgfjarqj) = vaxmervqcm zyfyhitftl (agckrqjhfv, wioakfxcqh - cerqxcdeeg)
-
24 May 2019
(Etomidate)
adndrollge(msjgfjarqj) = kiutavpfwd zyfyhitftl (agckrqjhfv, xvjvwprpwa - irowwbqysf)
Not Applicable
-
-
Etomidate-midazolam
kvliubxhff(kntraajbln) = qtfnfwlwfx feccxfuben (nugtcxsawt )
Positive
01 Oct 2018
Propofol-midazolam
kvliubxhff(kntraajbln) = egxdkyvbrt feccxfuben (nugtcxsawt )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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