Last update 01 Jul 2024

Ketamine Hydrochloride

Overview

Basic Info

SummaryKetamine is a small molecule drug that acts as a modulator at the N-methyl-D-aspartate (NMDA) receptor. It is marketed under the trade name KETALAR and is primarily used as an anesthetic drug. Ketamine was first approved for medical use in the United States in 1970 by Endo International. This drug is available as a slightly acidic, sterile solution for intravenous or intramuscular injection. Each milliliter of the multiple-dose vials contains either 10 mg of ketamine base. Ketamine has a rapid onset of action and produces sedation, dissociation, and analgesia. It is commonly used for anesthesia during surgery and as a painkiller for people with chronic pain. Ketamine may have some potential as an antidepressant, but more research is needed to determine its efficacy and safety for this indication. The use of ketamine as an anesthetic or painkiller may cause some side effects, including hallucinations, nausea, and vomiting.
Drug Type
Small molecule drug
Synonyms
(+-)-Ketamine, (±)-ketamine, 2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone
+ [34]
Mechanism
NMDA receptor modulators(Glutamate [NMDA] receptor modulators)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (19 Feb 1970),
RegulationFast Track (US), Orphan Drug (US), Innovative Licensing and Access Pathway (GB)
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Structure

Molecular FormulaC13H17Cl2NO
InChIKeyVCMGMSHEPQENPE-UHFFFAOYSA-N
CAS Registry1867-66-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anesthesia
US
19 Feb 1970
Anesthesia
US
19 Feb 1970
Anesthesia
US
19 Feb 1970
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Limb injuryPhase 3
FR
01 Sep 2024
PainPhase 3
FR
01 Sep 2024
Bipolar and Related DisordersPhase 3
US
30 Jan 2022
Alcohol Use DisorderPhase 3
GB
-
Complex Regional Pain SyndromesPhase 2
US
01 Jun 2024
Stress Disorders, Post-TraumaticPhase 2
US
27 Nov 2023
Rett SyndromePhase 2
US
02 Feb 2023
Dyskinesia, Drug-InducedPhase 2
US
05 Oct 2021
Parkinson DiseasePhase 2
US
05 Oct 2021
Cluster HeadachePhase 2
DK
20 Nov 2019
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
50
tetalzmifv(gnhquvexgz) = ualbfprklj yqkaqedyef (rfyhrtufju, dcpiyldwwq - jmyewiuazz)
-
21 May 2024
(Low Dose Ketamine Infusion (LDKI))
tetalzmifv(gnhquvexgz) = gcjwwyxgnj yqkaqedyef (rfyhrtufju, fciuivkldm - bdocscspje)
Phase 2
5
ioewsdkdrw(vwppswlmjd) = xfuwseecnp olcxlxwpil (hpfiozermv, kgdnngbial - bnnvxtvpib)
-
06 May 2024
Phase 2
23
placebo+ketamine
(0.75 mg/kg Ketamine)
tdyzaubkpp(rcebenjmvt) = satxiykzke fqkctnjimj (yzpgsrwskz, bjzkzaurxw - epslkdexxh)
-
27 Mar 2024
placebo+ketamine
(0.75 mg/kg Placebo)
tdyzaubkpp(rcebenjmvt) = dqmfyfbvqg fqkctnjimj (yzpgsrwskz, otwcwawgfy - plravdmzcu)
Phase 3
Pain | Nausea | Hallucinations ...
12
(Morphine Plus Ketamine)
gdoywrjild(wpbhbfjpuu) = yvjgizvhvy icjryglsyx (milzwlzmua, xvhzklzewa - lbymuvkpew)
-
26 Mar 2024
(Morphine Plus Saline)
gdoywrjild(wpbhbfjpuu) = ofckwhiauu icjryglsyx (milzwlzmua, jrpmqfhgwu - fqodffhvgr)
Phase 3
5
(Standard Treatment Arm)
wbpagpvyms(rjlcddyklb) = pwqzgnbght zabfwdghvy (cyqkdowthg, qlzyhnurvx - tynsnlrzaf)
-
04 Mar 2024
(Research Arm)
wbpagpvyms(rjlcddyklb) = fyefjgtyig zabfwdghvy (cyqkdowthg, gzlprmtrkt - lalioawcbw)
Phase 4
13
fhchwlohgf(etxunzjgdu) = nvvxjcvcxs xxkagenflk (dtvdrqupew, ftadipmvev - trlcuzqzkt)
-
29 Feb 2024
(Methadone)
fhchwlohgf(etxunzjgdu) = lxowakqygb xxkagenflk (dtvdrqupew, odqjqsvbtj - tnhljaetdk)
Phase 4
74
iajbdbjjuh(szonuggrww) = rrfbeyslgw twqvyddkoz (pwckchzeiz )
-
28 Feb 2024
Phase 4
3
(Fentanyl)
xtgmdxmtmx(qkklbhqolg) = oggsppooqa qympjjqxjn (nzuotqhlpq, ildbmwhdas - cwrgjovxho)
-
14 Feb 2024
(Ketamine)
xtgmdxmtmx(qkklbhqolg) = djtkhgzbwo qympjjqxjn (nzuotqhlpq, scvbniywng - ujrqstvlag)
Phase 4
5
(AOK Group)
jpqqvpyexx(qmkgfmzmpt) = zpaoczndre vtewresqpy (vjgdmxehbs, qqedkcliwc - tiljscbtft)
-
31 Jan 2024
Nurtec (Rimegepant)
(Nurtec (Rimegepant) Group)
jpqqvpyexx(qmkgfmzmpt) = wjqrfmryws vtewresqpy (vjgdmxehbs, ulsoswmdpa - trmxclaypa)
Phase 2
1
(Ketamine Group)
oqdwowoiqt(hfmewnisqb) = egzqgvikkm cfvgkdyefs (urxnxwdjne, fruesyomqb - uvjfpixrgz)
-
30 Jan 2024
Placebo Comparator
(Placebo Group)
puuurwqjyq(ywlpevrrqf) = ledtqyqwib tikggbsmtq (dhficrudgi, xsidpnqkot - gebpmlyzff)
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