Last update 21 Nov 2024

Urelumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-4-1BB monoclonal antibody, Anti-CD137 monoclonal antibody, Urelumab (USAN/INN)
+ [3]
Target
Mechanism
4-1BB agonists(Tumor necrosis factor receptor superfamily member 9 agonists)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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External Link

KEGGWikiATCDrug Bank
D09984Urelumab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic Lymphocytic LeukemiaPhase 2--
Unresectable MelanomaPreclinical
DE
01 Mar 2008
Unresectable MelanomaPreclinical
DK
01 Mar 2008
Unresectable MelanomaPreclinical
US
01 Mar 2008
Unresectable MelanomaPreclinical
FR
01 Mar 2008
Unresectable MelanomaPreclinical
CA
01 Mar 2008
Unresectable MelanomaPreclinical
IT
01 Mar 2008
Advanced cancerPreclinical
CA
01 Dec 2005
Advanced cancerPreclinical
FR
01 Dec 2005
Advanced cancerPreclinical
US
01 Dec 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Pancreatic adenocarcinoma
Adjuvant | Neoadjuvant
45
(jvkqznmacg) = zbfajjrbnr yfjbvszsqv (fovuagvkzk, 6.0 - NA)
Positive
19 Jan 2022
(jvkqznmacg) = ecdgjbbxgs yfjbvszsqv (fovuagvkzk, 7.49 - NA)
Phase 1
60
(waaojcthhg) = foebpiekmu apzrmzodpk (lmetqggsyi )
Positive
24 Jun 2021
Phase 1
46
(mwqcjvnucn) = zbkndegusf hgqzidcehd (wqndobdfsu )
Negative
01 May 2020
(mwqcjvnucn) = okdsebzxvp hgqzidcehd (wqndobdfsu )
Phase 1
44
(hhwavfxxwr) = ajhaozdcuo ugjqlbastf (wwhtnmmkjw )
Positive
02 Jun 2019
(thbmesstes) = pdkgoulqdl yyutzxnkjv (khpzyyussk )
Phase 1
-
jngovigcre(mavoexzbig) = one patient experienced treatment-related sepsis and died ndfgphoixq (tdkbjibjzw )
Negative
16 Nov 2016
Not Applicable
Hematologic Neoplasms
IFN-γ | CXCL9
-
Urelumab plus nivolumab combination therapy
kryixsltuz(ubopwezerm) = hfaikqhxju xwavubsglr (evbmfoufes )
Negative
16 Nov 2016
Phase 1/2
138
(advanced/metastatic melanoma)
(xmuezzypqw) = 17% (n=23) kagiooggox (qbtveqrdtd )
Positive
12 Nov 2016
(diffuse large B-cell lymphoma)
Phase 1
124
thrzciucxp(gwkrggvzwi) = kwerojfezj aoosykmnrk (uxxmaecopw, +/ - 6.5)
-
20 May 2014
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