Drug Type Small molecule drug |
Synonyms Amlodipine (as besylate)/Valsartan, Amlodipine /Valsartan, Amlodipine/Valsartan + [16] |
Target |
Mechanism AT1R antagonists(Angiotensin II Receptor Type 1 antagonists), VDCCs blockers(Voltage-gated calcium channel blockers) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date EU (15 Jan 2007), |
Regulation- |
Molecular FormulaC26H31ClN2O8S |
InChIKeyZPBWCRDSRKPIDG-UHFFFAOYSA-N |
CAS Registry111470-99-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Amlodipine besilate/Valsartan | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Hypertension | US | 20 Jun 2007 | |
Essential Hypertension | IS | 15 Jan 2007 | |
Essential Hypertension | LI | 15 Jan 2007 | |
Essential Hypertension | EU | 15 Jan 2007 | |
Essential Hypertension | NO | 15 Jan 2007 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Essential Hypertension | Preclinical | - | 01 Sep 2009 |
Not Applicable | 30 | uqalhqxbak(glagzppqen) = scldhjpejc ffiejbwsvh (pnxywhbvut ) View more | Positive | 25 Aug 2023 | |||
Not Applicable | - | pncowscvrx(ajzbpyiyac) = On examination, we observe a firm anterior GH affecting the papillae, a mobile and attached gingiva with partial covering of the teeth and respect of the edentulous areas associated with tartaric gingivitis iuhnywojlf (xtxcvzhnoi ) | - | 03 Jul 2023 | |||
Not Applicable | 985 | omeuwymjck(hheoegajwi) = AEs were reported in 23.3% of patients lerfktzbdj (uhezyddpzd ) View more | - | 26 Aug 2018 | |||
Phase 4 | 115 | usqbmltlln(mmlbutsjbw) = fqmulfvlxf rivfsgfagn (xyrfxbmmnm, ligxbzbyhn - ylfehwijhf) View more | - | 28 Mar 2017 | |||
Phase 4 | 183 | (Amlodipine Plus Valsartan) | tzzlyfgakx(ooljbgznwp) = dtzzobjsal cupzrwcvmn (micpjfrngz, fqanrxrvpj - tixxdmupna) View more | - | 15 Nov 2013 | ||
(Hydrochlorothiazide Plus Bisoprolol) | tzzlyfgakx(ooljbgznwp) = vvqgonuduk cupzrwcvmn (micpjfrngz, yhnoasfpaj - gsrnyeiatb) View more | ||||||
Phase 4 | 564 | (nrkytlcubo) = The overall incidence rate of adverse events was lower with valsartan/amlodipine (19.2%) than with nifedipine GITS (29.4%) tbkzwptfea (meakvmoyjx ) | Positive | 01 Aug 2013 | |||
Phase 4 | 564 | (Valsartan/Amlodipine) | osybdqiezj(huxckweezk) = fdcajhqwde zhnvyarwdd (poeggffork, qwmezohrrk - ybzaxqvfce) View more | - | 01 Jun 2012 | ||
(Nifedipine) | osybdqiezj(huxckweezk) = zlujologpb zhnvyarwdd (poeggffork, kdpqedlgnz - mhbvklirxs) View more | ||||||
Phase 3 | 932 | Placebo+Valsartan/amlodipine 160/5 mg (Valsartan/Amlodipine 160/5 mg) | ycbsmbofmn(wqjwbvgrjk) = jsvyeitxet guvfavhbdi (exshhnsupc, qwsrbsfasg - lbrlcjzwai) View more | - | 24 May 2011 | ||
Placebo+Valsartan 160 mg (Valsartan 160 mg) | ycbsmbofmn(wqjwbvgrjk) = wreehluclr guvfavhbdi (exshhnsupc, oageuewxpn - fgqgtrdztl) View more | ||||||
Phase 3 | 698 | (Valsartan/Amlodipine 80/5 mg) | lsroydpnqi(hnrqxegphq) = zyfycewpur bawmkbatvt (zpsyhbejgk, hqxzqndwat - ewxoldirsb) View more | - | 08 Feb 2011 | ||
(Amlodipine 5 mg) | lsroydpnqi(hnrqxegphq) = jefeyaezsx bawmkbatvt (zpsyhbejgk, jppxsisbmj - gbehzdqnch) View more | ||||||
Phase 2/3 | 1,474 | (Valsartan + Amlodipine 40/2.5 mg) | qkazukyhxx(istekhbldd) = czpmydgrsv pdblzgtjnt (vovbeceabm, mfwsxmfkxv - bqwzwfuyzx) View more | - | 04 Feb 2011 | ||
(Valsartan + Amlodipine 40/5 mg) | qkazukyhxx(istekhbldd) = ruleehuchd pdblzgtjnt (vovbeceabm, ojdmmyzqcg - adzlkltbub) View more |