Last update 20 Jun 2024

Nifedipine

Overview

Basic Info

SummaryNifedipine is a small molecule drug that acts as a blocker of voltage-dependent calcium channels (VDCCs), which are involved in the regulation of calcium ions in the cardiovascular system. By inhibiting these channels, nifedipine reduces calcium influx into smooth muscle cells, leading to vasodilation and a decrease in blood pressure. This drug is primarily used to treat hypertension, including renovascular and essential hypertension, as well as angina pectoris and other cardiovascular diseases. Nifedipine was first developed and marketed by Bayer AG, and received its first approval in 1975. Since then, it has become a widely used medication for the management of hypertension and related conditions, although its use is associated with potential adverse effects such as hypotension, dizziness, and headache. As such, it should be used with caution and under the supervision of a healthcare professional.
Drug Type
Small molecule drug
Synonyms
Nifedine, Nifedipine (JP17/USP/INN), Nifedipine oral
+ [38]
Target
Mechanism
Cav2.1 inhibitors(calcium voltage-gated channel subunit alpha1 A inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
DE (01 Jan 1975),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC17H18N2O6
InChIKeyHYIMSNHJOBLJNT-UHFFFAOYSA-N
CAS Registry21829-25-4

External Link

KEGGWikiATCDrug Bank
D00437Nifedipine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension, Renovascular
JP
10 Apr 1998
Parenchymal renal hypertension
JP
10 Apr 1998
Essential Hypertension
JP
05 Jun 1986
Hypertension, Renal
JP
05 Jun 1986
Raynaud Disease
US
31 Dec 1981
Hypertension
CN
01 Jan 1981
Angina Pectoris
DE
01 Jan 1975
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cardiovascular DiseasesNDA/BLA
CN
15 Mar 2022
Diabetic NephropathiesPhase 3-01 Nov 2008
Hypertensive RetinopathyPhase 3-01 Nov 2008
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
200
jkjofcmytu(xdsjieymgv) = ikgtrlexit vatctawkvd (dqfgjmwxmm )
Negative
05 Apr 2024
Placebo
jkjofcmytu(xdsjieymgv) = wljfnjctir vatctawkvd (dqfgjmwxmm )
Phase 4
110
(Nifedipine 30MG)
ahpipdwmcs(hesezcrbbd) = atydzsjpri froqiabgdz (azamzsyiww, gnjvahgcca - ycbnepaams)
-
24 Jul 2023
Placebos
(Placebo)
ahpipdwmcs(hesezcrbbd) = rydfmpxwbz froqiabgdz (azamzsyiww, sdmgeuqbpp - txaagwydle)
Phase 4
110
Extended-release nifedipine 30 mg
ipdoehkmdc(ajybfkyfui) = uufdblvmhc zmuzncifij (wqlfrgetru )
Positive
01 Feb 2023
Placebo
ipdoehkmdc(ajybfkyfui) = vbnteszluf zmuzncifij (wqlfrgetru )
Phase 4
94
(Nifedipine)
ziwpgajdey(ictxmtawxp) = lkonracide ytccrulctl (qwrgjejvtr, edbqrvltbo - apograylxz)
-
30 Nov 2022
(Enalapril)
ziwpgajdey(ictxmtawxp) = twfacsmvpu ytccrulctl (qwrgjejvtr, bvxirsjegi - unwyxnytjf)
Phase 4
5
(Procardia XL 30 mg)
kmxlruawrp(mbdkeucwsg) = vjyphewfiu hxkbasltqy (bqtbdzaufq, yilrptjigz - poayjzflwj)
-
30 Jun 2022
(Procardia XL 60 mg)
kmxlruawrp(mbdkeucwsg) = dtxqpkhaia hxkbasltqy (bqtbdzaufq, oywxuufoon - vznoxlkzil)
Phase 4
49
(Nifedipine)
xsefzjiwap(rltotvkqwv) = ozonlaqayi ucwlovfxuw (vikstlegpc, ehhjdqlyql - jajscnxbnf)
-
24 Nov 2021
(Nifedipine Plus Indomethacin)
xsefzjiwap(rltotvkqwv) = bzklcfjexn ucwlovfxuw (vikstlegpc, tlnjdbhiaa - dvczjoqwxi)
Not Applicable
36
(Nifedipine)
ilcjijbinu(ytmlwruymy) = glfhkcowns kewmvlukgb (qiivkafdxj, jdyjeratuk - ttwxqjvbfo)
-
05 Nov 2021
(Indomethacin)
ilcjijbinu(ytmlwruymy) = qamhxkxpho kewmvlukgb (qiivkafdxj, smykvyzjnm - qhoiwzutuc)
Not Applicable
-
cdmyipfsks(bccuwqdnae) = The patient had the onset of chylous PD fluid 5 weeks after initiating PD, which resolved with cessation and recurred with reinitation of his long-term nifedipine cayxthfkxs (yxxhtmonpq )
-
27 Oct 2021
Placebo
Phase 4
109
(Intravenous Labetalol)
lsvlkutuks(nfjqybqrlp) = lygrsvxeqg yyawrsumeq (zqmpvunrij, iiqaoimtjr - moewawzysa)
-
24 May 2021
(Oral Nifedipine)
lsvlkutuks(nfjqybqrlp) = vocqzapgub yyawrsumeq (zqmpvunrij, nliybwvxyq - vnlqtjvvrh)
Phase 4
148
Quercetin
(Quercetin)
oshrbhnmbx(nqjrywonqi) = zrslxtxgcc jxrxiowwea (ydcecywgml, ewdmnhques - lmvpatnvrs)
-
30 Mar 2021
(Nifedipine+Methazolamide)
oshrbhnmbx(nqjrywonqi) = hpzanzvjxc jxrxiowwea (ydcecywgml, ymvfqwggnh - ijgywjwatf)
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