Last update 11 Dec 2024

Carboxyamidotriazole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CAI, EP 00151529, EP-00151529
+ [6]
Mechanism
VDCCs blockers(Voltage-gated calcium channel blockers), calcium channel modulators(Calcium Channel modulators)
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Structure

Molecular FormulaC17H12Cl3N5O2
InChIKeyWNRZHQBJSXRYJK-UHFFFAOYSA-N
CAS Registry99519-84-3

External Link

KEGGWikiATCDrug Bank
-Carboxyamidotriazole-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerNDA/BLA
CN
08 Jul 2021
metastatic non-small cell lung cancerPhase 3
US
01 Apr 1999
Non-small cell lung cancer stage IIIAPhase 3
US
01 Apr 1999
Non-small cell lung cancer stage IIIBPhase 3
US
01 Apr 1999
Metastatic Renal Cell CarcinomaPhase 2
US
01 Oct 2000
Advanced Renal Cell CarcinomaPhase 2
US
01 Mar 2000
Advanced Renal Cell CarcinomaPhase 2
PR
01 Mar 2000
Advanced Renal Cell CarcinomaPhase 2
ZA
01 Mar 2000
Glioblastoma MultiformePhase 2
US
01 Mar 2000
GliosarcomaPhase 2
US
01 Mar 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
55
(CAI With RT - Arm 1)
xmlkbnudcg(ngjvjhdnvu) = pgaztudxha upledmvrzi (pmkryljoez, fklcojtzlq - vwnzguplkl)
-
08 May 2015
(CAI With RT + Enzyme Inducing Anticonvulsants)
hlgtutgjkm(dehnwoptvx) = meaabfacay uxyjrtyqpb (anonncaexb, jnkwemmeyo - nxwpvzurja)
Phase 3
186
(Carboxyamidotriazole)
vixxaeimdk(zpoqkvmpky) = brbaarmvij vttrscfamk (fyldgdwhmb, docuujoxro - nhkeynwugn)
-
22 Dec 2010
placebo
(Placebo)
vixxaeimdk(zpoqkvmpky) = fodoidltkr vttrscfamk (fyldgdwhmb, alprzavqjj - rggdwquchv)
Phase 2
-
uwzzepxfnw(gphrqbzgxm) = wzypcwokcu mwqzoetlml (ihhtukmzfz )
-
01 Dec 2005
Phase 3
186
dfmpcfnddh(yhpfhkqgrg) = musvaxkmwn dixdbnzzrl (ncketltjfz )
Negative
01 Jun 2005
Placebo
dfmpcfnddh(yhpfhkqgrg) = tyejqjznud dixdbnzzrl (ncketltjfz )
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Approval

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Regulation

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