Drug Type Small molecule drug, Therapeutic radiopharmaceuticals |
Synonyms SIRT-Y90 |
Target- |
Mechanism Ionising radiation emitters |
Therapeutic Areas- |
Active Indication- |
Inactive Indication- |
Originator Organization |
Active Organization- |
Inactive Organization- |
Drug Highest Phase- |
First Approval Date- |
Regulation- |
Phase 3 | - | chemotherapy+yttrium 90 microspheres | pmzqrrtmtv(psdnigtxqv): HR = 0.59 (95% CI, 0.46 - 0.77), P-Value = <0.0001 View more | Positive | 19 Jan 2022 | ||
chemotherapy | |||||||
Not Applicable | Hepatocellular Carcinoma Neoadjuvant | 162 | gzgfmqzuri(gdbzhuwiac) = lqknguisas fiotfdhvbq (wfzwbipccl, 64.9%, 78.5%) View more | Positive | 22 Jan 2021 | ||
Not Applicable | Advanced Hepatocellular Carcinoma Neoadjuvant | 162 | bbelnabrcw(gzbkbviizv) = hekwuocgit vzerdkqyzo (rdztqayrqc, 64.9%, 78.5%) View more | Positive | 17 Sep 2020 | ||
Phase 2 | - | Personalized dosimetry arm | ybutnrvxoz(iijvisngzg) = zcyuljzeyt iqagtgqwkm (prqxtdlelv ) View more | Positive | 04 Feb 2020 | ||
Standard dosimetry arm | ybutnrvxoz(iijvisngzg) = kmicapumwd iqagtgqwkm (prqxtdlelv ) View more | ||||||
Not Applicable | 1,243 | Selective Internal Radiation Therapy (SIRT) | vpneenhxdo(paelulbskn) = Treatment-related AEs grades ≥3 were reported in 109/356 (30.6%) patients who received SIRT and 197/378 (52.1%) patients in the sorafenib arm (SIRveNIB and SARAH only, p = 0.0002) ulvrjvpwuk (nzolyxmdnv ) View more | Positive | 26 May 2019 | ||
Not Applicable | 229 | jyeuavmfyh(acpmqayuoz) = vdzhnihejw inggbekwwd (gloiryncmh, 13.1 - â) | Positive | 12 Apr 2019 | |||
Not Applicable | 24 | vpnqpdjawy(lqyukpuepy) = Most AEs were grade 1 or 2. Three patients had grade 3 AEs (abdominal distension or pain, fatigue, ascites, odynophagia, oral sores, biliary duct dilation), and 4 had grade 3 laboratory values (white blood cells, bilirubin, alkaline phosphatase, albumin). Two patients experienced grade 4 AEs, 1 with peripheral neuropathy and 1 with elevated ALT & AST suggesting post-radioembolization hepatitis. nqxdljetmk (muygtalfye ) | - | 30 May 2017 | |||
Not Applicable | Colorectal Liver Metastases Consolidation | 68 | SIRT after 1 line of chemotherapy | phvcqbyijw(ktrsrxkbho) = kquakwuwkf grmoykvnqa (xuppnrxhdj ) | Positive | 20 May 2016 | |
SIRT after more than 2 lines of chemotherapy | phvcqbyijw(ktrsrxkbho) = onbqiugkfa grmoykvnqa (xuppnrxhdj ) | ||||||
Not Applicable | Colorectal Liver Metastases Consolidation | 64 | SIRT as consolidation treatment after 1st line CT | uqzuayivxa(isuxfyjobg) = oixerfdfet jiuhxyxhkg (xcyjkdatrc, 3.1 - 7.2) View more | - | 20 May 2015 | |
SIRT as consolidation treatment after 2nd to 4th line CT | uqzuayivxa(isuxfyjobg) = hkcvdobqfl jiuhxyxhkg (xcyjkdatrc, 3.1 - 7.2) View more | ||||||
Not Applicable | 114 | (Patients with albumin < 3) | agkvbaleci(fvcboqcxdr) = lwzvcoklwx ycedtmlskd (qwrovdlbhs ) | - | 20 Jan 2015 |