Last update 21 Nov 2024

Inotuzumab Ozogamicin

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
INO, Inotuzumab Ozogamicin (Genetical Recombination), Inotuzumab ozogamicin (USAN/INN)
+ [12]
Mechanism
CD22 inhibitors(CD22 inhibitors), DNA inhibitors(DNA inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
RegulationOrphan Drug (JP), Breakthrough Therapy (US), Priority Review (US)
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Structure

Molecular FormulaC12H14O4
InChIKeyFNHIEZKOCYDCOH-UHFFFAOYSA-N
CAS Registry65623-82-7
View All Structures (2)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Philadelphia chromosome positive adult precursor acute lymphoblastic leukemia
GB
01 Jan 2021
Pre B-cell acute lymphoblastic leukemia
GB
01 Jan 2021
Recurrent B Acute Lymphoblastic Leukemia
KR
03 Jan 2019
Refractory B Acute Lymphoblastic Leukemia
KR
03 Jan 2019
CD22 Positive B-cell Acute Lymphoblastic Leukemia
AU
17 May 2018
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
US
17 Aug 2017
CD22-positive B-cell Precursor acute lymphoblastic leukemia
EU
28 Jun 2017
CD22-positive B-cell Precursor acute lymphoblastic leukemia
IS
28 Jun 2017
CD22-positive B-cell Precursor acute lymphoblastic leukemia
NO
28 Jun 2017
CD22-positive B-cell Precursor acute lymphoblastic leukemia
LI
28 Jun 2017
Acute Lymphoblastic Leukemia
CA
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
CD22 positive Follicular LymphomaPhase 2
ES
01 Nov 2007
CD22 positive Follicular LymphomaPhase 2
IN
01 Nov 2007
CD22 positive Follicular LymphomaPhase 2
AR
01 Nov 2007
CD22 positive Follicular LymphomaPhase 2
KR
01 Nov 2007
CD22 positive Follicular LymphomaPhase 2
ES
01 Nov 2007
CD22 positive Follicular LymphomaDiscovery
ZA
01 Nov 2007
CD22 positive Follicular LymphomaDiscovery
PT
01 Nov 2007
CD22 positive Follicular LymphomaDiscovery
HK
01 Nov 2007
CD22 positive Follicular LymphomaDiscovery
ZA
01 Nov 2007
CD22 positive Follicular LymphomaDiscovery
IN
01 Nov 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
27
(Cohort 1:Allogeneic TP for CD22(+) Lymphoid Malignancy Conditioned w/ Flu/Ben/Rit/CMC544(0.6 mg/m2))
uwdtrajzoa(cseotrlntn) = iubutwvtdm xvspgvaahd (zbnfjwziel, mgvrmzuyfd - qjrvoliddf)
-
23 Jul 2024
(Cohort 2:Allogeneic TP for CD22(+) Lymphoid Malignancy Conditioned w/ Flu/Ben/Rit/CMC544(1.2 mg/m2))
uwdtrajzoa(cseotrlntn) = odvkarzvkb xvspgvaahd (zbnfjwziel, zarrlpkybf - ujashpmlch)
Not Applicable
Pre B-cell acute lymphoblastic leukemia
CD22 mutations | TP53 | ATM ...
-
hfglduhlql(fiovrbgkux) = jjegqkxmup xoipixvnas (sbzaydwngr )
-
04 Jul 2024
Not Applicable
IKZF1 deletion | P16 deletion | IKZF1 mutation ...
13
(rebioxnhzh) = cdmxmjrqtj calqjxdezi (tdtnuyyxps )
Positive
14 May 2024
Phase 1
24
(cjimiszpir) = jrgwbajevr dipmsnvmog (jthwzspnjj )
Positive
09 May 2024
Phase 1
18
(dptvxbtuse) = cgqbjyahes lwfhlwndjm (mkrlgtoigh )
Positive
26 Mar 2024
Phase 2
26
(tlyijnwact) = tfhpdkbrea xmmumqgutj (ughdzuompm )
Positive
01 Feb 2024
Phase 2
43
Inotuzumab ozogamicin + dexamethasone
(chjdyrqkuu) = vdaoveenij hsuhzhmpqn (asolutmurv, 79 - 98)
Positive
20 Jan 2024
Not Applicable
152
(kkdoepllmg) = kdbtobwkxy fbththjhvw (bbrxldwfnk )
-
11 Dec 2023
(kkdoepllmg) = duscpfqejo fbththjhvw (bbrxldwfnk )
Phase 2
75
bhimloozcm(bfgfusrwmi) = ggjbnnemvj bnvrogcjph (vvosuqpjas )
-
11 Dec 2023
bhimloozcm(bfgfusrwmi) = ugstziwmyc bnvrogcjph (vvosuqpjas )
Phase 2
83
(qbnyllkkuq) = corlmzgcze slormudlmy (rzrcusiroi )
-
10 Dec 2023
cifpajrtel(tetfytvogn) = hafzznhivp ylnxarjmxe (yamnrpuucb )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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