Last update 20 Mar 2025

ROR1 CAR-T (Oncternal Therapeutics)

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
ROR1 CAR-T cell therapy (Oncternal Therapeutics), ROR1 targeted CAR-T therapy (Oncternal Therapeutics), ROR1-CAR-T (Oncternal Therapeutics)
+ [1]
Target
Action
modulators
Mechanism
ROR1 modulators(Inactive tyrosine-protein kinase transmembrane receptor ROR1 modulators)
Inactive Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
B-Cell Malignant NeoplasmPhase 2
United States
09 May 2023
Non-Hodgkin LymphomaPhase 2
United States
05 Oct 2022
Hematologic NeoplasmsPreclinical--
Solid tumorPreclinical--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
9
CAR T Cells+ONCT-808
(ONCT-808 1x10^6 CAR T Cells/kg)
tyqveliica(rrpuisrtef) = arhskqmcrj rbenigwjck (qrglixggbk, kodhuhcyis - hqzrlxsksd)
-
05 Dec 2024
CAR T Cells+ONCT-808
(ONCT-808 3x10^6 CAR T Cells/kg)
tyqveliica(rrpuisrtef) = yyulvwrldp rbenigwjck (qrglixggbk, ndvophjwre - dasufparal)
Phase 1/2
3
(euoguvftgz) = included decreased blood counts, pneumonia and Grade 1-2 cytokine release syndrome (CRS) as of a 4 December 2023 data cutoff wfaaziwdxv (kqyjjbtlxp )
Positive
26 Dec 2023
Not Applicable
ROR1
-
iazeyyoeta(ppomdwxtlg) = rtbdqkaych miowbarwgp (lhrgynianq )
Positive
02 Nov 2023
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Regulation

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