ROR1

NM32 is a first-in-class half-life-enhanced T-cell engager targeting ROR1, a tumor associated antigen with broad expression in solid tumors and hematological malignancies Low molecular weight of NM32 allows to efficiently achieve higher tumor concentrations than larger immunoglobulin G molecules, the current standard format for CD3 engagers HORGEN, Switzerland, Oct. 30, 2024 (GLOBE NEWSWIRE) -- Numab Therapeutics AG (“Numab”) announced today the start of a Phase 1 clinical trial evaluating NM32, a next generation tri-specific immuno-oncology therapeutic targeting the receptor tyrosine kinase-like orphan receptor 1 (ROR1) and the T-cell receptor associated antigen CD3. The third binding moiety of NM32 targets serum albumin to provide half-life extension allowing for convenient bi-weekly dosing and to keep the lower molecular weight than immunoglobulin enabling efficient tumor penetration. “Generated from our proprietary Lambda-capTM and MATCHTM technology platform, NM32 represents a T-cell engager designed to help the patient’s immune system recognize and attack tumor cells. ROR1 is overexpressed on a wide spectrum of highly prevalent solid tumor indications but has very limited expression on normal tissue, making it an optimal antigen for a CD3 engager,” said David Urech, Ph.D., Founder and Chief Executive Officer of Numab Therapeutics. “We are pleased to start NM32’s clinical development path enabling us to potentially bring this novel therapy to patients with advanced solid tumors who are in need of treatment options that provide durable anti-tumor activity with a tolerable safety profile. Enrollment is progressing nicely, with patients completing the first treatment cycle of the initial dose level”, commented Martin Stern, Senior Vice President Clinical Science at Numab Therapeutics. “Despite the introduction of checkpoint inhibitors and several commercially available CD3 engagers for the treatment of hematological malignancies, there has been limited success in solid tumors mainly due to the lack of highly tumor-specific antigens allowing selective T-cell activation against tumor cells.” This multi-center Phase 1 study of NM32 is a dose-escalation trial to characterize the pharmacokinetic properties, pharmacodynamic effects and safety profile of NM32 and to select an optimal dosing regimen for further clinical development. It is planned to enroll up to 60 patients with solid tumors overexpressing ROR1 from major clinical sites across the United States. Generated preclinical data in non-human primates indicate a high potency and an excellent safety profile. About NM32 (NM32-2668)NM32 is a next generation tri-specific immuno-oncology drug targeting the receptor tyrosine kinase-like orphan receptor 1 (ROR1) and the T-cell receptor associated antigen CD3. The third domain targets serum albumin to provide half-life extension to allow convenient bi-weekly dosing. T-cell redirection using CD3 engagers is an established treatment modality showing high response rates and durable activity in hematological malignancies and has more recently also shown promising results for selected targets overexpressed in solid tumors. ROR1 is a clinically validated tumor associated antigen with overexpression in several indications with high unmet need including lung, breast, ovarian, endometrial, renal and gastric cancer and limited expression on healthy tissue. About Numab Therapeutics AGNumab Therapeutics AG is developing multi-specific antibody-based immunotherapies for inflammation and cancer. Reproducible plug-and-play therapeutic design process using proprietary platforms λ-CapTM and MATCHTM puts Numab in a unique position to overcome historical drug discovery barriers and build a pipeline of new and important medicines aimed to maximize patient benefits. Numab’s diverse research pipeline spans multiple therapeutic areas and creates the opportunity for the next generation of first-in-class and best-in-class medicines. Our lead candidate NM26, a unique multi-specific targeting IL-4/13 and IL-31 for best-in-class efficacy, is developed with a vision of delivering a lifelong cure to patients suffering from atopic dermatitis and other potential indications. Multiple partnerships with leading pharma companies validate the platform and development capabilities. For further information, visit https://www.numab.com. For further details, please contact: Numab TherapeuticsDavid UrechChief Executive Officerd.urech@numab.com Investor Contact: Patrick Till Meru Advisorsptill@meruadvisors.com

BOTHELL, WA, USA I October 29, 2024 I Immunome, Inc. (Nasdaq: IMNM), a biotechnology company focused on developing first-in-class and best-in-class targeted cancer therapies, recently presented promising preclinical data for IM-1021 and the associated proprietary ADC payload HC74. The results were presented in a poster entitled “Preclinical evaluation of IM-1021, a ROR1-targeted antibody-drug conjugate with a novel topoisomerase I linker payload” at the 36 th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona on October 24, 2024. The poster included preclinical results for IM-1021 in both liquid and solid tumors while also highlighting the enhanced ADME properties of HC74: Immunome expects to submit an IND for the IM-1021 program to the FDA in the first quarter of 2025. “We believe that transformative ADCs require matching the target with the right combination of antibody, linker, and payload. Based on this data, we continue to believe that IM-1021 is a promising preclinical candidate,” said Immunome’s Chief Scientific Officer Jack Higgins, Ph.D. “HC74’s differentiated profile, including substantial potency in chemo-resistant cell lines, provides intriguing opportunities for clinical development. We look forward to submitting the IM-1021 IND and starting clinical trials upon IND clearance to further validate these findings.” A copy of the poster is available in the “Events & Presentations” portion of Immunome’s website. About Immunome, Inc. Immunome is a clinical-stage targeted oncology company committed to developing first- and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs.) In addition to a portfolio of discovery-stage ADCs, our pipeline includes AL102, a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors, as well as IM-1021, a ROR1 ADC, and IM-3050, a FAP-targeted radioligand, both of which are the subject of INDs expected to be submitted in the first quarter of 2025. For more information, visit www.immunome.com . SOURCE: Immunome

Poster presentation on TB-Bs1's therapeutic potential in ROR2 positive cancers at SITC 2024 NEW YORK, Oct. 25, 2024 /PRNewswire/ -- Traverse Biotech, Inc., a privately held biotechnology company specializing in innovative immunotherapy solutions, today announced that it will present a poster at the Society for Immunotherapy of Cancer's (SITC) 39th Annual Meeting, taking place November 6-10, 2024, in Houston, TX. The presentation will showcase preclinical results on TB-Bs1, Traverse's T-cell engaging product candidate targeting ROR2-positive solid tumors. Poster Presentation Details: Title: ROR2-targeted T-cell engager as a novel therapeutic approach in solid tumors Abstract Number: 1065 Location: Exhibit Halls A-B, George R. Brown Convention Center Date: Friday, November 8, 2024 Attending from Traverse Biotech: Brandy Houser, Ph.D., Co-Founder & Chief Executive Officer Jing Gong, Ph.D., Director of Strategy and Operations About TB-Bs1 TB-Bs1 is a first-in-class T-cell Engaging (TCE) bispecific antibody built on the DuoBody™ platform targeting ROR2. ROR2 is a receptor that has been shown to cause cancer cell proliferation and that has also been identified as a negative prognostic indicator. ROR2 is a member of the receptor tyrosine kinase-like orphan receptor family associated with Wnt signaling. We and others have confirmed ROR2 protein expression in liquid and solid cancers, with TB-Bs1 demonstrating consistent cytotoxic activity against ROR2-positive cancer cell lines. In a humanized mouse model, TB-Bs1 significantly inhibited tumor growth in a dose-dependent manner with minimal adverse effects. These results highlight the potential of TB-Bs1 as a targeted immunotherapy for ROR2-positive cancers. About Traverse Biotech Traverse Biotech, Inc. is a privately held US biotechnology company that is building a pipeline of innovative immunotherapy products from clinically validated platforms. Each product can reverse immune dysfunction in high unmet medical needs where the native immune system is unable to respond effectively. The Company licenses global commercialization rights for its products from selected biopharmaceutical companies in an original partnership model to accelerate therapeutic development to clinical proof-of-concept. Traverse's lean and flexible structure enables rapid clinical evaluation and cost reduction, ensuring faster patient access to novel therapies across selected diseases. For more information about Traverse Biotech, please visit or engage with us on LinkedIn. SOURCE Traverse Biotech WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED