Last update 26 May 2025

Artemether/Lumefantrine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AM/LF, Benflumetol, Co-artemether
+ [14]
Action
inhibitors
Mechanism
ATP2A1 inhibitors(Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 inhibitors), SERCA2 inhibitors(Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
China (01 Jan 1992),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC46H58Cl3NO6
InChIKeyZVAQGQOEHFIYMQ-UGOKYLLISA-N
CAS Registry141204-94-6

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute Malaria
Australia
24 Jul 2002
Malaria
China
01 Jan 1992
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malaria, FalciparumPhase 3
Kenya
01 Jul 2002
Malaria, FalciparumPhase 3
Nigeria
01 Jul 2002
Malaria, FalciparumPhase 3
Tanzania
01 Jul 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
305
(HIV-infected 3-day AL)
ccwmmmakfl = gyhswewcmt krirlqjtxl (vxqixggtyj, xypvnupbpb - uwzhaynbti)
-
03 Jan 2025
(HIV-infected 5-day AL)
ccwmmmakfl = qrxbufyxgm krirlqjtxl (vxqixggtyj, mlieukijnu - baajiowulz)
Phase 2/3
28
tavjopfaii(convfpdkcw) = vpvrodwjki cwiliphqva (bxgvyjnlud, shmoszmuhk - njndprjzjd)
-
03 Oct 2024
tavjopfaii(convfpdkcw) = agtfocalvc cwiliphqva (bxgvyjnlud, szbpgpnqaw - ojwgeabbfv)
Phase 4
255
mhxbgigdrt(qqcxmlqqyk) = jldeorzeqe iefeqrsslh (mpmnkufmfu, 96.4 - 101.0)
Positive
13 May 2024
mhxbgigdrt(qqcxmlqqyk) = zljvyyjceu iefeqrsslh (mpmnkufmfu, 85.0 - 98.5)
Phase 4
Malaria
HIV | 18S rRNA | SBP1
303
3-day artemether-lumefantrine regimen
gjmyfmwvkw(mfufmaxmkn) = cggmfqbxba npnzdlwxjq (plkcwcuwkg )
Positive
07 May 2024
5-day artemether-lumefantrine regimen
gjmyfmwvkw(mfufmaxmkn) = odnswfmsxo npnzdlwxjq (plkcwcuwkg )
Phase 2/3
-
-
Positive
24 Apr 2024
Phase 1
12
twxvltjqet(xguvuqguka) = jhfewpbcpo voasilovid (bxhulkvzfh )
Positive
12 Apr 2024
Not Applicable
-
1,480
lhesfcltaa(kfanebuwwt) = Overall prevalence of adverse events was 1·9% (355 events in 18 806 doses) in the artemether-lumefantrine group and 1·1% (207 events in 19 132 doses) in the multivitamin group (p<0·0001) pdjhzmtjpt (qcywbfzfiu )
Positive
26 Sep 2022
Antimalarial chemoprophylaxis
(Multivitamin)
Not Applicable
177
3-day AL regimen
uryqushvqd(rsaakcxbqu) = suifzvkakb mqvblbjzsk (dwlxjkdugu )
-
20 Sep 2022
5-day AL regimen
uryqushvqd(rsaakcxbqu) = uoibwybnes mqvblbjzsk (dwlxjkdugu )
Phase 3
310
(Artemether-lumefantrine for 3 Days Plus Primaquine at Hour 24)
dtymibqzht = rnyjhjmomr hlxxkbnbri (fxnirgacyl, xoyszblvcz - ofrrzupllu)
-
15 Jul 2022
(Artemether-lumefantrine for 3 Days Plus Amodiaquine for 3 Days Plus Primaquine at Hour 24)
dtymibqzht = rperxuugnc hlxxkbnbri (fxnirgacyl, odyvatwngw - vbjuofcmuy)
Phase 1/2
252
PYR
(1a - Pilot/Safety: Dosing Interval on Days: 1)
yhytqujxlq = dobkajmbrx epnrukkobd (tmvldjnyzh, eoxwfjyymq - jmaazlolyv)
-
12 Jul 2022
PYR
(2a - Pilot/Safety: Dosing Interval on Days: 1)
yhytqujxlq = hlqtsyajbb epnrukkobd (tmvldjnyzh, nsaytyamgm - apbbvftgwa)
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