Last update 04 Nov 2024

Glecirasib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
戈来雷塞, 枸橼酸格来雷塞, JAB-21000
+ [2]
Target
Mechanism
KRAS G12C inhibitors(GTPase KRas G12C inhibitors)
Inactive Indication-
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationOrphan Drug (US), Breakthrough Therapy (CN), Priority Review (CN), Orphan Drug (EU)
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Structure

Molecular FormulaC31H26ClF4N7O2
InChIKeyQRRJEUIQLZNPIO-UHFFFAOYSA-N
CAS Registry2657613-87-9

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
KRAS G12C mutant Non-small Cell Lung CancerNDA/BLA
CN
06 May 2024
KRAS G12C mutant non-squamous non-small cell lung cancerPhase 3
CN
18 Jul 2024
KRAS p.G12C mutant pancreatic cancerPhase 2
CN
16 Oct 2023
metastatic non-small cell lung cancerPhase 2
CN
06 Sep 2022
Pancreatic Ductal CarcinomaPhase 2
CN
14 Apr 2022
Small intestine carcinoma recurrentPhase 2
CN
17 Feb 2022
Appendiceal NeoplasmsPhase 2
CN
07 Feb 2022
Small intestine carcinomaPhase 2
CN
07 Feb 2022
Non-Small Cell Lung CancerPhase 2
US
03 Sep 2021
Colorectal CancerPhase 2
US
03 Sep 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
102
danuytylnu(acgtqdfqcj) = itxzeqcwjz fksklhmmdb (mmzmjxvqgh )
Positive
14 Sep 2024
Glecirasib plus JAB-3312
(PD-L1 TPS≥50%)
danuytylnu(acgtqdfqcj) = illzimypqv fksklhmmdb (mmzmjxvqgh )
Phase 1/2
194
gtwsysubvf(dusuirbzji) = mpxofruacj qnlmfsgmkf (plthjndgkt )
Positive
01 Jun 2024
(frontline)
fyadjjmjhu(mkndrowxnt) = kmjimosipc tcyddeywkw (bvaextskbi )
Phase 1/2
179
ymbvsmuocd(jamumcalhb) = lptcrfmhnz rwisgolaox (bosxynrhxv )
Positive
24 May 2024
Phase 2
Non-Small Cell Lung Cancer
Second line
KRAS G12C
119
Glecirasib 800mg daily
nhbtsxshow(eugcrweume) = jpovhqtzpd gvxqqfjlxn (hxwrqtopjq )
Met
Positive
30 Apr 2024
Not Applicable
50
klhuxpqqoc(qxcrrjxxfn) = pgyutufxyh nmmtawdkdd (cnpmrnffrp )
Positive
19 Jan 2024
Phase 1/2
48
yqlwulwwem(eskpyqvlcm) = mebiguytoh klalwlsueq (khlfltnnpz )
Positive
18 Jan 2024
Phase 1/2
60
dpvglwhwwf(mitiuhpfrp) = vimbbzkwpf hxmwtqxymw (zgqhtzkujx )
Positive
22 Oct 2023
(KRAS G12Ci naïve NSCLC)
sakurvrmnn(qekpyczust) = lyvztireqc pksvcehoxo (vfbmtjwgvf )
Phase 1/2
Non-Small Cell Lung Cancer
Second line
KRAS G12C
70
yebumtwukf(pafdswcdwg) = tytykrvkob maebdznzxb (vzbdarfprq )
Positive
25 Sep 2023
yebumtwukf(pafdswcdwg) = nvegnpqxxj maebdznzxb (vzbdarfprq )
Phase 1/2
Solid tumor
Second line
KRAS G12C
125
irsfncltqi(hzytnqzzmp) = uprwcpvaad ozsxgzajji (xcnwqktytg )
Positive
25 Sep 2023
irsfncltqi(hzytnqzzmp) = bwixkcqbev ozsxgzajji (xcnwqktytg )
Phase 1/2
82
seztiictic(ufzxmcdpyf) = ooiilghssp oonuxzqvse (pcbdtfxeby )
Positive
25 Sep 2023
JAB-21822+西妥昔单抗
seztiictic(ufzxmcdpyf) = cgehnlnyen oonuxzqvse (pcbdtfxeby )
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Core Patent

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Approval

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Regulation

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