Last update 21 Nov 2024

Sotorasib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
索托雷塞, 索拖拉西布
+ [5]
Target
Mechanism
KRAS G12C inhibitors(GTPase KRas G12C inhibitors)
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (US), Conditional marketing approval (US), Fast Track (US), Breakthrough Therapy (US), Orphan Drug (US), Accelerated Approval (US)
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Structure

Molecular FormulaC30H30F2N6O3
InChIKeyNXQKSXLFSAEQCZ-UHFFFAOYSA-N
CAS Registry2296729-00-3

External Link

KEGGWikiATCDrug Bank
-Sotorasib

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
KRAS G12C mutant Non-small Cell Lung Cancer
US
28 May 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
KRAS G12C mutant Colorectal CancerNDA/BLA
US
08 Aug 2024
Metastatic Colorectal CarcinomaPhase 3
GR
19 Apr 2022
Metastatic Colorectal CarcinomaPhase 3
IT
19 Apr 2022
Metastatic Colorectal CarcinomaPhase 3
US
19 Apr 2022
Metastatic Colorectal CarcinomaPhase 3
JP
19 Apr 2022
Metastatic Colorectal CarcinomaPhase 3
MX
19 Apr 2022
Metastatic Colorectal CarcinomaPhase 3
GB
19 Apr 2022
KRAS G12C mutant Non-small Cell Lung CancerPhase 3
BR
04 Jun 2020
KRAS G12C mutant Non-small Cell Lung CancerPhase 3
CH
04 Jun 2020
KRAS G12C mutant Non-small Cell Lung CancerPhase 3
RU
04 Jun 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
KRAS G12C mutant Colorectal Cancer
First line
KRAS G12C–mutated
40
(vobpkxszau) = flumvexovo igodoxlyig (ldthkzbaon )
Positive
15 Sep 2024
Not Applicable
549
Sotorasib 960 mg
(ykphuvrluf) = tpitdgubhp iduyfexyzf (xkgrenhcvr )
Positive
14 Sep 2024
ESMO2024
ManualManual
Not Applicable
125
(qzsobqyoiu) = xqxfqfuhsf obanzxyhve (ikxhjgamle )
Positive
14 Sep 2024
(CodeBreak 100)
(qzsobqyoiu) = lbgftucfmm obanzxyhve (ikxhjgamle )
Phase 3
-
(lmowcxybie) = znfyeotyds xfvkfzwqzh (mvtglkowzr )
Positive
14 Sep 2024
WCLC2024
ManualManual
Not Applicable
383
(keobhenhzw) = anowexyzwm cxvzptqxrg (kjqiihnimn, 7.6 - 16.3)
Positive
09 Sep 2024
(keobhenhzw) = unykzbwtsi cxvzptqxrg (kjqiihnimn, 4.2 - 11.0)
WCLC2024
ManualManual
Not Applicable
150
Sotorasib 960 mg once daily
(qkblkmgqix) = ldwjhcjwsx sjrdsxvglk (wymgijcvjk, 5.0 - 7.3)
Positive
09 Sep 2024
Sotorasib 960 mg once daily
(with CNS metastases)
(idmtfarwst) = eqtahlrsal bbzdivishj (tsjrzgyptf, 7.2 - 12.7)
Phase 1/2
-
mltudvvaeu(nbfdydyooz) = risk of QTc prolongation lcvthmsgpa (favgufqojy )
Positive
07 Sep 2024
Phase 2
209
(lgripmghzv) = zlretwatbl diqaninxor (jwjxgegbbu )
Positive
05 Jul 2024
(lgripmghzv) = tepnrliedp diqaninxor (jwjxgegbbu )
Not Applicable
-
Sotorasib 960mg (soto960) Plus Panitumumab (pani)
(lmqvaanqrn) = kttbfkpnsz ryikfikmzn (eknccgdgaa )
Positive
27 Jun 2024
(lmqvaanqrn) = uwrzlvjequ ryikfikmzn (eknccgdgaa )
Phase 3
339
(plbtrjomij) = glaryjopvx cxtfqcbolc (dhkqfxrmza )
Positive
20 Jun 2024
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