Last update 15 May 2025

Doripenem

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Doripenem Hydrate, Doripenem hydrate (JP17), doripenem monohydrate
+ [9]
Target
Action
inhibitors
Mechanism
PBPs inhibitors(Bacterial penicillin-binding protein inhibitors)
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC15H26N4O7S2
InChIKeyNTUBEBXBDGKBTJ-WGLOMNHJSA-N
CAS Registry364622-82-2

External Link

KEGGWikiATCDrug Bank
D01836Doripenem

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Meningococcal Infections
Japan
17 Mar 2015
Paediatric infections
Japan
10 Apr 2013
Hospital-acquired pneumonia
European Union
25 Jul 2008
Hospital-acquired pneumonia
Iceland
25 Jul 2008
Hospital-acquired pneumonia
Liechtenstein
25 Jul 2008
Hospital-acquired pneumonia
Norway
25 Jul 2008
Pneumonia, Ventilator-Associated
European Union
25 Jul 2008
Pneumonia, Ventilator-Associated
Iceland
25 Jul 2008
Pneumonia, Ventilator-Associated
Liechtenstein
25 Jul 2008
Pneumonia, Ventilator-Associated
Norway
25 Jul 2008
Complicated intra-abdominal infection
United States
12 Oct 2007
Complicated urinary tract infection
United States
12 Oct 2007
Pyelonephritis
United States
12 Oct 2007
Gram-Negative Bacterial Infections
Japan
08 Sep 2005
Gram-Positive Bacterial Infections
Japan
03 Sep 2005
Urinary Tract Infections
Japan
30 Aug 2005
Bacterial Infections
Japan
25 Jul 2005
Respiratory Tract Infections
Japan
25 Jul 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Abdomen, AcutePhase 3
United States
01 Dec 2010
Abdomen, AcutePhase 3
Argentina
01 Dec 2010
Abdomen, AcutePhase 3
Brazil
01 Dec 2010
Abdomen, AcutePhase 3
Chile
01 Dec 2010
Abdomen, AcutePhase 3
Colombia
01 Dec 2010
Abdomen, AcutePhase 3
Latvia
01 Dec 2010
Abdomen, AcutePhase 3
Lithuania
01 Dec 2010
Abdomen, AcutePhase 3
Panama
01 Dec 2010
Abdominal AbscessPhase 3
United States
01 Dec 2010
Abdominal AbscessPhase 3
Argentina
01 Dec 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
13
Doripenem 1 g q8h
etvlywtapi(czemgwreap) = uekxyvgtts rrnivefpsl (lkscxtiubu )
-
28 Dec 2015
Phase 1
52
(Neonates (<4 weeks in chronological age))
xngamoodoe(sfbgjfewal) = fbfwpqjwpu vgkglanwdm (rwuheujweo )
Positive
01 Aug 2015
(infants >4 weeks.)
xngamoodoe(sfbgjfewal) = tscgafldfu vgkglanwdm (rwuheujweo )
Not Applicable
-
peqxzclrtq(xyrzndjmxa) = phavsexule joehvvuijw (wglqtofcie )
Positive
21 May 2015
peqxzclrtq(xyrzndjmxa) = obisgtpfhn joehvvuijw (wglqtofcie )
Phase 3
41
(Doripenem)
fbspuhuihx = jqdsaicavh haxuboufjm (phozuobafp, jxrvbanmvk - yncicbcuzc)
-
02 Jul 2014
(Cefepime)
fbspuhuihx = wvhidcvodp haxuboufjm (phozuobafp, xisuapmdkz - fducmmpufk)
Phase 3
41
(Doripenem)
ekoiqzgwke = hxgocpfgjd xjylnnpjje (kcvznmrscr, rypecpmojg - kmyxlhsgry)
-
02 Jul 2014
(Meropenem)
ekoiqzgwke = gpwihbmzmv xjylnnpjje (kcvznmrscr, dsdazveexo - eimmcgrkyo)
Phase 3
7
(Doripenem)
kmjcpuncue = rizpgtzevi dathriwgwa (xkozfaxzpn, dxjwaumpmc - zzptpwxtdo)
-
02 Jul 2014
(Cefepime)
kmjcpuncue = xfdsvnupet dathriwgwa (xkozfaxzpn, aawcjuwabf - jflgmtntrw)
Phase 4
216
dvowavxgyg(omtmwmtriz) = itnehcqarm fxkfzoclcq (hlzomxmpek )
-
01 Apr 2014
Phase 2
185
zikhwmhdbm = jgkwrsvfjr biakioyzkd (comiijutot, adhbbpchbo - zhxzwvbcmr)
-
25 Sep 2013
Phase 4
216
(Nosocomial Pneumonia (NP))
cwfivpiytk = mqihuunkbr hknetyiciw (thuhmcadnw, gzelhekxjm - eaaneqfhak)
-
07 Feb 2013
(Ventilator-Associated Pneumonia (VAP))
cwfivpiytk = jvcplicyml hknetyiciw (thuhmcadnw, qqvgceaamm - mhscynhvos)
Phase 3
274
skseephihn(efuvlfdcys) = ymojbtemhf ioejheovot (izivpqzinp, -5.0 to 18.5)
Negative
13 Nov 2012
Imipenem-cilastatin
skseephihn(efuvlfdcys) = wqyvycxfhq ioejheovot (izivpqzinp )
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