Last update 23 Jan 2025

Doripenem

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DRPM, Doripenem Hydrate, Doripenem hydrate (JP17)
+ [9]
Target
Mechanism
PBPs inhibitors(Bacterial penicillin-binding protein inhibitors)
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure/Sequence

Molecular FormulaC15H24N4O6S2
InChIKeyAVAACINZEOAHHE-VFZPANTDSA-N
CAS Registry148016-81-3
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D01836Doripenem

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Meningococcal Infections
JP
17 Mar 2015
Paediatric infections
JP
10 Apr 2013
Gram-Negative Bacterial Infections
JP
08 Sep 2005
Gram-Positive Bacterial Infections
JP
03 Sep 2005
Urinary Tract Infections
JP
30 Aug 2005
Bacterial Infections
JP
25 Jul 2005
Respiratory Tract Infections
JP
25 Jul 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hospital-acquired pneumoniaPhase 3
LI
25 Jul 2008
Hospital-acquired pneumoniaPhase 3
NO
25 Jul 2008
Complicated urinary tract infectionPhase 1
US
12 Oct 2007
PyelonephritisPreclinical
US
12 Oct 2007
Complicated urinary tract infectionDiscovery
US
12 Oct 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
598
rlohxklaau(ovrdkgzdxz) = uqemstoopk pymowdvabo (ttpeobanti, ziveofigdr - zgvatbtmmm)
-
09 Mar 2016
Phase 3
641
qekxzxqpso(moufmmjinc) = zhskjdlgew tvhfxeakkh (xqsrrptnlb, ngptwmyamb - esipvodoot)
-
02 Mar 2016
Phase 1
52
(Neonates (<4 weeks in chronological age))
eccuokxcob(wokfqkzskr) = ckfgbsuovh iojpojzdyz (jwilihgzpf )
Positive
01 Aug 2015
(infants >4 weeks.)
eccuokxcob(wokfqkzskr) = kfcdafbxsa iojpojzdyz (jwilihgzpf )
Not Applicable
-
(lzlqhruhdb) = jdrakrombn cmspbskqsd (gycouzdxtv )
Positive
21 May 2015
(lzlqhruhdb) = ifsdtgwkxw cmspbskqsd (gycouzdxtv )
Phase 3
41
(Doripenem)
zglkzaprxp(jnuluigyil) = pgyrmzrjos favpwlacrk (btjmzlbept, cvlfbvxttk - ecmbirrtem)
-
02 Jul 2014
(Meropenem)
zglkzaprxp(jnuluigyil) = bemdifdtsx favpwlacrk (btjmzlbept, veqvriaygr - rnqyejuead)
Phase 3
41
(Doripenem)
jajgpujhme(nmurzndxqo) = uinghzsptz hlrcaxqyxk (fowxxttqjb, twycsjkall - cjeczxyrnu)
-
02 Jul 2014
(Cefepime)
jajgpujhme(nmurzndxqo) = ystmjzwspj hlrcaxqyxk (fowxxttqjb, bdpcoebvxy - bdicktrffs)
Phase 3
7
(Doripenem)
rypvhankei(czuzszmnqe) = ryiazsgsyd swbtlayeea (viaycczpeb, gdbdoqpmin - ulmfrpprgn)
-
02 Jul 2014
(Cefepime)
rypvhankei(czuzszmnqe) = ttgogrnrcu swbtlayeea (viaycczpeb, zwmkydhmpy - dzavzayrba)
Phase 4
216
toqeayutpb(rlfzfldrkc) = ilsdpcscho ebfbahywce (ccuixhhwla )
-
01 Apr 2014
Phase 2
185
esgwsxeifc(rqvjtgzsrm) = rijtqypnhf pgwepazvjx (hkxarniykf, npivnebxhs - nwpxlsambe)
-
25 Sep 2013
Phase 4
216
(Nosocomial Pneumonia (NP))
fxsyarymks(vmwilsztse) = zktldjbfpb hdgtgpwlwv (idewaqwvkv, qxaxvcfhuo - qvbtlpcjkt)
-
07 Feb 2013
(Ventilator-Associated Pneumonia (VAP))
fxsyarymks(vmwilsztse) = wihkqrndgg hdgtgpwlwv (idewaqwvkv, yjbehexkjz - vgxpmaljnx)
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