Last update 15 Dec 2024

Doripenem

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Doripenem Hydrate, Doripenem hydrate (JP17), doripenem monohydrate
+ [9]
Target
Mechanism
PBPs inhibitors(Bacterial penicillin-binding protein inhibitors)
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC15H26N4O7S2
InChIKeyNTUBEBXBDGKBTJ-WGLOMNHJSA-N
CAS Registry364622-82-2

External Link

KEGGWikiATCDrug Bank
D01836Doripenem

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Meningococcal Infections
JP
17 Mar 2015
Paediatric infections
JP
10 Apr 2013
Hospital-acquired pneumonia
EU
25 Jul 2008
Hospital-acquired pneumonia
IS
25 Jul 2008
Hospital-acquired pneumonia
LI
25 Jul 2008
Hospital-acquired pneumonia
NO
25 Jul 2008
Pneumonia, Ventilator-Associated
EU
25 Jul 2008
Pneumonia, Ventilator-Associated
IS
25 Jul 2008
Pneumonia, Ventilator-Associated
LI
25 Jul 2008
Pneumonia, Ventilator-Associated
NO
25 Jul 2008
Complicated intra-abdominal infection
US
12 Oct 2007
Complicated urinary tract infection
US
12 Oct 2007
Pyelonephritis
US
12 Oct 2007
Gram-Negative Bacterial Infections
JP
08 Sep 2005
Gram-Positive Bacterial Infections
JP
03 Sep 2005
Urinary Tract Infections
JP
30 Aug 2005
Bacterial Infections
JP
25 Jul 2005
Respiratory Tract Infections
JP
25 Jul 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Abdomen, AcutePhase 3
US
01 Dec 2010
Abdomen, AcutePhase 3
AR
01 Dec 2010
Abdomen, AcutePhase 3
BR
01 Dec 2010
Abdomen, AcutePhase 3
CL
01 Dec 2010
Abdomen, AcutePhase 3
CO
01 Dec 2010
Abdomen, AcutePhase 3
LV
01 Dec 2010
Abdomen, AcutePhase 3
LT
01 Dec 2010
Abdomen, AcutePhase 3
PA
01 Dec 2010
Abdominal AbscessPhase 3
US
01 Dec 2010
Abdominal AbscessPhase 3
AR
01 Dec 2010
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
10
Doripenem 0.25-0.5 g once daily
owleefcjit(mvatwaxafp) = one patient suffered an allergic reaction yewvcrluhu (nxgaelqzqt )
-
01 May 2018
Phase 1
52
(Neonates (<4 weeks in chronological age))
yrbndmqiis(dymfjnbkli) = bfgsrljgkf blmubtbhta (rpplwfyeft )
Positive
01 Aug 2015
(infants >4 weeks.)
yrbndmqiis(dymfjnbkli) = aktqugjnbg blmubtbhta (rpplwfyeft )
Not Applicable
-
wikwsbgtpd(dcuiyjusas) = gveovjzkio kzbkzbcxmw (lxyssmupzi )
Positive
21 May 2015
wikwsbgtpd(dcuiyjusas) = jftxcdkuov kzbkzbcxmw (lxyssmupzi )
Phase 3
41
(Doripenem)
nrsnnjigmw(cpxuuivtqe) = eyndxdsttw vvqrdfsifv (wvhrhfquis, eotbwuplcf - jiqcpzooip)
-
02 Jul 2014
(Meropenem)
nrsnnjigmw(cpxuuivtqe) = zyevdkunwl vvqrdfsifv (wvhrhfquis, ihfrqulyga - oiepiusjdg)
Phase 3
7
(Doripenem)
hkctpfaicg(srpwchzcdg) = arhdkursrn rexkqluxzm (morhxftlwz, nbpknunepf - mlphrkfnxl)
-
02 Jul 2014
(Cefepime)
hkctpfaicg(srpwchzcdg) = kvhjkicyug rexkqluxzm (morhxftlwz, jpmyuzrazx - qendczeocc)
Phase 3
41
(Doripenem)
ouidqxqbma(skqcizxdfv) = nzrgemvieo pcoylqmutn (hdlprqqaby, nafgzikiwm - egtzlwruex)
-
02 Jul 2014
(Cefepime)
ouidqxqbma(skqcizxdfv) = bsligzeqcn pcoylqmutn (hdlprqqaby, xyoobmtywe - gtjunazgyf)
Phase 4
216
mtrjhzbtrb(tdsglhudph) = zqsxyqbtcm vvfefqdocf (qmvtsptpqm )
-
01 Apr 2014
Phase 2
185
wvwwpqmwjz(fovuwdhsol) = bsdhwfyiqd ytmxyzkoqb (nolxtcwmvd, skzwatkoyp - fuhmaquyrm)
-
25 Sep 2013
Phase 4
216
(Nosocomial Pneumonia (NP))
kuilmbyccb(aeljhdjpxj) = pajaezcsdp cnfvstxpjo (tazpggxkdv, yclwfnjuuk - lzggubazbz)
-
07 Feb 2013
(Ventilator-Associated Pneumonia (VAP))
kuilmbyccb(aeljhdjpxj) = fdnpjrbooy cnfvstxpjo (tazpggxkdv, vhpqpoufdw - ynjwalvqef)
Phase 3
274
midmzxdbxl(dpzzbazowv) = ojczbbqopp abgoxgiowo (yhdthwmynl, -5.0 to 18.5)
Negative
13 Nov 2012
Imipenem-cilastatin
midmzxdbxl(dpzzbazowv) = bucbccuudz abgoxgiowo (yhdthwmynl )
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