Drug Type Small molecule drug |
Synonyms Doripenem Hydrate, Doripenem hydrate (JP17), doripenem monohydrate + [9] |
Target |
Mechanism PBPs inhibitors(Bacterial penicillin-binding protein inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date JP (25 Jul 2005), |
RegulationOrphan Drug (US) |
Molecular FormulaC15H26N4O7S2 |
InChIKeyNTUBEBXBDGKBTJ-WGLOMNHJSA-N |
CAS Registry364622-82-2 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Meningococcal Infections | JP | 17 Mar 2015 | |
Paediatric infections | JP | 10 Apr 2013 | |
Hospital-acquired pneumonia | EU | 25 Jul 2008 | |
Hospital-acquired pneumonia | IS | 25 Jul 2008 | |
Hospital-acquired pneumonia | LI | 25 Jul 2008 | |
Hospital-acquired pneumonia | NO | 25 Jul 2008 | |
Pneumonia, Ventilator-Associated | EU | 25 Jul 2008 | |
Pneumonia, Ventilator-Associated | IS | 25 Jul 2008 | |
Pneumonia, Ventilator-Associated | LI | 25 Jul 2008 | |
Pneumonia, Ventilator-Associated | NO | 25 Jul 2008 | |
Complicated intra-abdominal infection | US | 12 Oct 2007 | |
Complicated urinary tract infection | US | 12 Oct 2007 | |
Pyelonephritis | US | 12 Oct 2007 | |
Gram-Negative Bacterial Infections | JP | 08 Sep 2005 | |
Gram-Positive Bacterial Infections | JP | 03 Sep 2005 | |
Urinary Tract Infections | JP | 30 Aug 2005 | |
Bacterial Infections | JP | 25 Jul 2005 | |
Respiratory Tract Infections | JP | 25 Jul 2005 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Abdomen, Acute | Phase 3 | US | 01 Dec 2010 | |
Abdomen, Acute | Phase 3 | AR | 01 Dec 2010 | |
Abdomen, Acute | Phase 3 | BR | 01 Dec 2010 | |
Abdomen, Acute | Phase 3 | CL | 01 Dec 2010 | |
Abdomen, Acute | Phase 3 | CO | 01 Dec 2010 | |
Abdomen, Acute | Phase 3 | LV | 01 Dec 2010 | |
Abdomen, Acute | Phase 3 | LT | 01 Dec 2010 | |
Abdomen, Acute | Phase 3 | PA | 01 Dec 2010 | |
Abdominal Abscess | Phase 3 | US | 01 Dec 2010 | |
Abdominal Abscess | Phase 3 | AR | 01 Dec 2010 |
Phase 3 | - | 10 | Doripenem 0.25-0.5 g once daily | owleefcjit(mvatwaxafp) = one patient suffered an allergic reaction yewvcrluhu (nxgaelqzqt ) | - | 01 May 2018 | |
NCT01381848 (Pubmed) Manual | Phase 1 | 52 | (Neonates (<4 weeks in chronological age)) | yrbndmqiis(dymfjnbkli) = bfgsrljgkf blmubtbhta (rpplwfyeft ) View more | Positive | 01 Aug 2015 | |
(infants >4 weeks.) | yrbndmqiis(dymfjnbkli) = aktqugjnbg blmubtbhta (rpplwfyeft ) View more | ||||||
Not Applicable | Febrile Neutropenia First line | - | wikwsbgtpd(dcuiyjusas) = gveovjzkio kzbkzbcxmw (lxyssmupzi ) View more | Positive | 21 May 2015 | ||
wikwsbgtpd(dcuiyjusas) = jftxcdkuov kzbkzbcxmw (lxyssmupzi ) View more | |||||||
Phase 3 | 41 | (Doripenem) | nrsnnjigmw(cpxuuivtqe) = eyndxdsttw vvqrdfsifv (wvhrhfquis, eotbwuplcf - jiqcpzooip) View more | - | 02 Jul 2014 | ||
(Meropenem) | nrsnnjigmw(cpxuuivtqe) = zyevdkunwl vvqrdfsifv (wvhrhfquis, ihfrqulyga - oiepiusjdg) View more | ||||||
Phase 3 | 7 | (Doripenem) | hkctpfaicg(srpwchzcdg) = arhdkursrn rexkqluxzm (morhxftlwz, nbpknunepf - mlphrkfnxl) View more | - | 02 Jul 2014 | ||
(Cefepime) | hkctpfaicg(srpwchzcdg) = kvhjkicyug rexkqluxzm (morhxftlwz, jpmyuzrazx - qendczeocc) View more | ||||||
Phase 3 | 41 | (Doripenem) | ouidqxqbma(skqcizxdfv) = nzrgemvieo pcoylqmutn (hdlprqqaby, nafgzikiwm - egtzlwruex) View more | - | 02 Jul 2014 | ||
(Cefepime) | ouidqxqbma(skqcizxdfv) = bsligzeqcn pcoylqmutn (hdlprqqaby, xyoobmtywe - gtjunazgyf) View more | ||||||
Phase 4 | 216 | mtrjhzbtrb(tdsglhudph) = zqsxyqbtcm vvfefqdocf (qmvtsptpqm ) View more | - | 01 Apr 2014 | |||
Phase 2 | 185 | wvwwpqmwjz(fovuwdhsol) = bsdhwfyiqd ytmxyzkoqb (nolxtcwmvd, skzwatkoyp - fuhmaquyrm) View more | - | 25 Sep 2013 | |||
Phase 4 | 216 | (Nosocomial Pneumonia (NP)) | kuilmbyccb(aeljhdjpxj) = pajaezcsdp cnfvstxpjo (tazpggxkdv, yclwfnjuuk - lzggubazbz) View more | - | 07 Feb 2013 | ||
(Ventilator-Associated Pneumonia (VAP)) | kuilmbyccb(aeljhdjpxj) = fdnpjrbooy cnfvstxpjo (tazpggxkdv, vhpqpoufdw - ynjwalvqef) View more | ||||||
Phase 3 | 274 | midmzxdbxl(dpzzbazowv) = ojczbbqopp abgoxgiowo (yhdthwmynl, -5.0 to 18.5) View more | Negative | 13 Nov 2012 | |||
Imipenem-cilastatin | midmzxdbxl(dpzzbazowv) = bucbccuudz abgoxgiowo (yhdthwmynl ) View more |