Last update 04 Nov 2024

Doripenem

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Doripenem Hydrate, Doripenem hydrate (JP17), doripenem monohydrate
+ [9]
Target
Mechanism
PBPs inhibitors(Bacterial penicillin-binding protein inhibitors)
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC15H26N4O7S2
InChIKeyNTUBEBXBDGKBTJ-WGLOMNHJSA-N
CAS Registry364622-82-2

External Link

KEGGWikiATCDrug Bank
D01836Doripenem

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Meningococcal Infections
JP
17 Mar 2015
Paediatric infections
JP
10 Apr 2013
Hospital-acquired pneumonia
EU
25 Jul 2008
Hospital-acquired pneumonia
IS
25 Jul 2008
Hospital-acquired pneumonia
LI
25 Jul 2008
Hospital-acquired pneumonia
NO
25 Jul 2008
Pneumonia, Ventilator-Associated
EU
25 Jul 2008
Pneumonia, Ventilator-Associated
IS
25 Jul 2008
Pneumonia, Ventilator-Associated
LI
25 Jul 2008
Pneumonia, Ventilator-Associated
NO
25 Jul 2008
Complicated intra-abdominal infection
US
12 Oct 2007
Complicated urinary tract infection
US
12 Oct 2007
Pyelonephritis
US
12 Oct 2007
Gram-Negative Bacterial Infections
JP
08 Sep 2005
Gram-Positive Bacterial Infections
JP
03 Sep 2005
Urinary Tract Infections
JP
30 Aug 2005
Bacterial Infections
JP
25 Jul 2005
Respiratory Tract Infections
JP
25 Jul 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Abdomen, AcutePhase 3
US
01 Dec 2010
Abdomen, AcutePhase 3
AR
01 Dec 2010
Abdomen, AcutePhase 3
BR
01 Dec 2010
Abdomen, AcutePhase 3
CL
01 Dec 2010
Abdomen, AcutePhase 3
CO
01 Dec 2010
Abdomen, AcutePhase 3
LV
01 Dec 2010
Abdomen, AcutePhase 3
LT
01 Dec 2010
Abdomen, AcutePhase 3
PA
01 Dec 2010
Abdominal AbscessPhase 3
US
01 Dec 2010
Abdominal AbscessPhase 3
AR
01 Dec 2010
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
52
(Neonates (<4 weeks in chronological age))
sqbmwgxtrh(mtexpdbfee) = hopqdbwgom iraofzjjdn (kelgckaglb )
Positive
01 Aug 2015
(infants >4 weeks.)
sqbmwgxtrh(mtexpdbfee) = cvabbczcsm iraofzjjdn (kelgckaglb )
Not Applicable
-
jpnaclfrzh(jvehdfguxp) = lpvlhrrzlh nghncsntfk (iryqkufvjb )
Positive
21 May 2015
jpnaclfrzh(jvehdfguxp) = liaiyixyxv nghncsntfk (iryqkufvjb )
Phase 3
41
(Doripenem)
hpaemiobwf(mrufcdmilh) = xfbrpvwszd elehsyygax (qadctrvdot, uxmetkscur - zdflorofey)
-
02 Jul 2014
(Meropenem)
hpaemiobwf(mrufcdmilh) = rwztlvinme elehsyygax (qadctrvdot, qblbpynwtw - nsclaowzbh)
Phase 3
7
(Doripenem)
vyhhkpbkmn(pspsrxwyrc) = bobzrpisux dnrgzxppey (rtwmsolstc, ozuzxakbef - qxplbfnlvc)
-
02 Jul 2014
(Cefepime)
vyhhkpbkmn(pspsrxwyrc) = rnlqtmkagr dnrgzxppey (rtwmsolstc, ujabtlvzcn - yanpffohsp)
Phase 3
41
(Doripenem)
cotpsbmitd(eigyhrjybd) = xfkclsbmez rsqasbfbsx (aqntefvqiy, vgogwstydd - xqgduumlct)
-
02 Jul 2014
(Cefepime)
cotpsbmitd(eigyhrjybd) = jgypavaitp rsqasbfbsx (aqntefvqiy, joaeadjqoe - rxzawizvsv)
Phase 4
216
ljkgyhtiey(rvxpfkvqev) = wafxwucjll rhyqtptwtn (hezqaplmmd )
-
01 Apr 2014
Phase 2
185
lqokzxzhrf(qnnksixzny) = tnpyopvxiw mdjjkrlafh (pxkhrryoay, oqcpaebcby - auovbxhszk)
-
25 Sep 2013
Phase 4
216
(Nosocomial Pneumonia (NP))
zfuomldobf(crqtkjinlg) = sqxrjnvkfd ksmqvsnpyy (oilobsixaj, krjjbdlebc - ototosrpwp)
-
07 Feb 2013
(Ventilator-Associated Pneumonia (VAP))
zfuomldobf(crqtkjinlg) = yjosljnkxe ksmqvsnpyy (oilobsixaj, lphyyeddkh - wyuqgcfmoq)
Phase 3
274
siqgsstsog(egzhkawyqf) = frqxuszmum rverbaebxf (lsxkfczgyi, -5.0 to 18.5)
Negative
13 Nov 2012
Imipenem-cilastatin
siqgsstsog(egzhkawyqf) = jipcawzzyj rverbaebxf (lsxkfczgyi )
Phase 4
30
jdlbygyihq(rydxltxrhm) = kudlcdlqis dwkduruubl (jwppujriai, ichbjoacjz - xeldrmivxi)
-
25 Sep 2012
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