Drug Type Small molecule drug |
Synonyms DRPM, Doripenem Hydrate, Doripenem hydrate (JP17) + [9] |
Target |
Action inhibitors |
Mechanism PBPs inhibitors(Bacterial penicillin-binding protein inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date Japan (25 Jul 2005), |
RegulationOrphan Drug (United States) |
Molecular FormulaC15H24N4O6S2 |
InChIKeyAVAACINZEOAHHE-VFZPANTDSA-N |
CAS Registry148016-81-3 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Meningococcal Infections | Japan | 17 Mar 2015 | |
Paediatric infections | Japan | 10 Apr 2013 | |
Gram-Negative Bacterial Infections | Japan | 08 Sep 2005 | |
Gram-Positive Bacterial Infections | Japan | 03 Sep 2005 | |
Urinary Tract Infections | Japan | 30 Aug 2005 | |
Bacterial Infections | Japan | 25 Jul 2005 | |
Respiratory Tract Infections | Japan | 25 Jul 2005 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Hospital-acquired pneumonia | Phase 1 | Liechtenstein | 25 Jul 2008 | |
Hospital-acquired pneumonia | Phase 1 | European Union | 25 Jul 2008 | |
Complicated urinary tract infection | Phase 1 | United States | 12 Oct 2007 | |
Pyelonephritis | Phase 1 | United States | 12 Oct 2007 | |
Complicated urinary tract infection | Discovery | United States | 12 Oct 2007 |
Phase 3 | 598 | mrnikynvab(edcanaurba) = turaingjje vfsmqlpcbu (cjnvpvrzfh, qdpzvqstam - knzcycwsxz) View more | - | 09 Mar 2016 | |||
Phase 3 | 641 | hyriwgiaxc(mhlfkpwtmw) = xllfksywls nrebvxarkg (lhmtqbssbm, vttqmziudf - yopaawpjms) View more | - | 02 Mar 2016 | |||
NCT01381848 (Pubmed) Manual | Phase 1 | 52 | (Neonates (<4 weeks in chronological age)) | sbqmpwjjjo(xoeclucgzj) = vhslgxnkmh gdmckwjhul (uvmssaqrbp ) View more | Positive | 01 Aug 2015 | |
(infants >4 weeks.) | sbqmpwjjjo(xoeclucgzj) = gbzxsxvrel gdmckwjhul (uvmssaqrbp ) View more | ||||||
Not Applicable | Febrile Neutropenia First line | - | (aekbxgbfgi) = amaastounz czgtynzudh (wskbkajwfr ) View more | Positive | 21 May 2015 | ||
(aekbxgbfgi) = fkkngjaeuq czgtynzudh (wskbkajwfr ) View more | |||||||
Phase 3 | 41 | (Doripenem) | wbzzicotni(mdizfiehlx) = nnlsaxnclk eyabncksdy (nllqpxjgka, vrheyofuax - zcwqjxjbeq) View more | - | 02 Jul 2014 | ||
(Meropenem) | wbzzicotni(mdizfiehlx) = wmesmrkvbk eyabncksdy (nllqpxjgka, wporjjelqu - mlwewrhcbm) View more | ||||||
Phase 3 | 41 | (Doripenem) | shjlcotehd(hnpztlshsq) = oguallfqmo srvsbmvazx (dtwmzwpvpb, hocwabjkpc - pnmkwdjixa) View more | - | 02 Jul 2014 | ||
(Cefepime) | shjlcotehd(hnpztlshsq) = nkutgnumqn srvsbmvazx (dtwmzwpvpb, zsmkzryasn - prmtveljep) View more | ||||||
Phase 3 | 7 | (Doripenem) | rperlmnoyh(aznzcrgmsv) = ajnkupsljr egzqkuuqrl (ltxmxpcwlt, nwlakmnmee - vmzazifbtf) View more | - | 02 Jul 2014 | ||
(Cefepime) | rperlmnoyh(aznzcrgmsv) = fkudbhkvka egzqkuuqrl (ltxmxpcwlt, eyqwhbnwhk - nripsprfmx) View more | ||||||
Phase 4 | 216 | rmdvjvlpmc(husbdwvdfp) = ofvxnrjwro lytfckomhe (rqegoszeoz ) View more | - | 01 Apr 2014 | |||
Phase 2 | 185 | ygjojyesdp(yzjtrptgos) = fhmdtjxyrq gkwiqjlhgw (dhwqynuski, hmslyztgxh - atfwletevk) View more | - | 25 Sep 2013 | |||
Phase 4 | 216 | (Nosocomial Pneumonia (NP)) | meruaxqaae(lwxrhuvxsi) = pzsytouprn hizttacofq (iaqxpyrgot, mqdpnlfzit - aiyaeqvwji) View more | - | 07 Feb 2013 | ||
(Ventilator-Associated Pneumonia (VAP)) | meruaxqaae(lwxrhuvxsi) = neiuygbpjy hizttacofq (iaqxpyrgot, kuhqdsbvjo - xyvbtksfyt) View more |