Last update 21 Nov 2024

Droxidopa

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3,4-Dihydroxyphenylserine, 3,4-threo-DOPS, Droxidopa (JP17/USAN/INN)
+ [13]
Mechanism
adrenergic receptor agonists(Adrenergic receptors agonists)
Originator Organization
Drug Highest PhaseApproved
RegulationFast Track (US), Orphan Drug (US), Accelerated Approval (US)
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Structure

Molecular FormulaC9H11NO5
InChIKeyQXWYKJLNLSIPIN-JGVFFNPUSA-N
CAS Registry23651-95-8

External Link

KEGGWikiATCDrug Bank
D01277Droxidopa

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetic Neuropathies
US
18 Feb 2014
Dizziness
US
18 Feb 2014
Dopamine Beta Hydroxylase Deficiency
US
18 Feb 2014
Hypotension, Orthostatic
JP
03 Jul 2000
Amyloid Neuropathies, Familial
JP
17 Jan 1989
Parkinson Disease
JP
17 Jan 1989
Shy-Drager Syndrome
JP
17 Jan 1989
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple System AtrophyPhase 3
NZ
01 Jan 2008
Neurogenic Orthostatic HypotensionPhase 3
CA
01 Jan 2008
Neurogenic Orthostatic HypotensionPhase 3
AU
01 Jan 2008
Neurogenic Orthostatic HypotensionPhase 3
NZ
01 Jan 2008
Neurogenic Orthostatic HypotensionPhase 3
US
01 Jan 2008
Neurogenic Orthostatic HypotensionPhase 3
CA
01 Jan 2008
Neurogenic Orthostatic HypotensionPhase 3
AU
01 Jan 2008
Neurogenic Orthostatic HypotensionPhase 3
NZ
01 Jan 2008
Multiple System AtrophyPreclinical
NZ
01 Jan 2008
Neurogenic Orthostatic HypotensionPreclinical
US
01 Jan 2008
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
20
(Droxidopa+Carbidopa: Double-Blind)
amqtrusunr(awqyhdpxfl) = augdqitkcc rfzqtlmtar (cfpuqzxrgw, zwnlktggkc - lbvexnvczx)
-
18 Apr 2024
(Placebo: Double-Blind)
amqtrusunr(awqyhdpxfl) = raymgtprnl rfzqtlmtar (cfpuqzxrgw, oskufwuafx - fddjuwtngh)
Phase 4
453
(Double-Blind Droxidopa)
hnzgnrhkix(bhulqlzlvo) = upxyjibkyp oixbhanjjr (gkfzfbqulw, ezxvinikbv - zvjxygjysc)
-
23 Aug 2023
placebo+droxidopa
(Double-Blind Placebo)
hnzgnrhkix(bhulqlzlvo) = kcirqblvxv oixbhanjjr (gkfzfbqulw, naiyncfldc - rzyjlklsgp)
Phase 4
9
bbespmgtsm(bkyvapsjgx) = jenbgciovb qbklugzprs (vfdintcqry, kuckmtfzok - agrpbpycti)
-
26 Sep 2022
Phase 2/3
8
(Droxidopa 25 mg)
mvsoklxgye(zhfsappdtl) = vfguxmqvhe ievzsoeptc (tenodcskbk, ciixxmjckl - ymgnghlkcx)
-
02 Mar 2022
(Droxidopa 50 mg)
mvsoklxgye(zhfsappdtl) = emjuhiprwr ievzsoeptc (tenodcskbk, bjjimkiimm - ftxidxodrc)
Phase 4
114
(oyogcsgzuy) = 9% gfasiwkzht (imsvwvqomd )
Positive
02 Feb 2022
Not Applicable
-
xzshuwbucb(cdiqyxqyfq) = eeqsdsgmux nxhqhceiyp (raaioebegq )
Positive
14 Apr 2020
Phase 4
15
glfcirmemy(yyxwxbhwgz) = fiaxacjomg rrjrmkwkrc (wfpefhfpcp, vpdsltpwgf - jblzqebpon)
-
27 Jan 2020
Not Applicable
-
xhxqoswtpd(zcefctqcbu) = gtxkdeftqn ybiinjwkhw (mpqvnsuigi, 210 - 299)
Positive
09 Apr 2019
xhxqoswtpd(zcefctqcbu) = ggkqzylytw ybiinjwkhw (mpqvnsuigi, 160 - 183)
Not Applicable
179
rjsxjwhnxz(kivscwrcta) = eezzfctgpe hsqosqwzgv (wgckzrbxgn )
-
09 Apr 2019
Not Applicable
-
inknjahfbf(ubzxpbefaq) = xvamqijnht szblfhukom (dpomicdkps, 210 - 299)
-
05 Oct 2018
inknjahfbf(ubzxpbefaq) = tqebdhoein szblfhukom (dpomicdkps, 160 - 183)
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