Last update 03 Oct 2024

Carvedilol

Overview

Basic Info

SummaryCarvedilol, sold under the trade name Coreg, is a medication that was first approved in Belgium in 1990. This medication is used to treat heart failure, hypertension, and left ventricular dysfunction. Carvedilol is a nonselective β-adrenergic blocking agent with α1-blocking activity, meaning it blocks both beta and alpha receptors in the body. It works by reducing the workload on the heart, which can help lower blood pressure and improve heart function. The chemical structure of Carvedilol is (±)-1­ (Carbazol-4-yloxy)-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol. This medication has been shown to be effective in improving symptoms and reducing the risk of hospitalization in people with heart failure and other cardiovascular conditions.
Drug Type
Small molecule drug
Synonyms
Carvedilol (JP17/USP/INN), Corever, Pluscor
+ [27]
Mechanism
ADRA1 antagonists(Adrenergic receptor alpha-1 antagonists), adrenergic receptor antagonists(Adrenergic receptors antagonists), β1-adrenergic receptor antagonists(Beta-1 adrenergic receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
Regulation-
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Structure

Molecular FormulaC24H26N2O4
InChIKeyOGHNVEJMJSYVRP-UHFFFAOYSA-N
CAS Registry72956-09-3

External Link

KEGGWikiATCDrug Bank
D00255Carvedilol

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Atrial Fibrillation
JP
24 Aug 2015
Myocardial Infarction
US
05 Sep 2007
Heart Failure
US
14 Sep 1995
Hypertension
US
14 Sep 1995
Ventricular Dysfunction, Left
US
14 Sep 1995
Angina Pectoris
JP
19 Jan 1993
Essential Hypertension
JP
19 Jan 1993
Hypertension, Renal
JP
19 Jan 1993
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ventricular DysfunctionPhase 3
TW
12 Aug 2022
Drug Resistant EpilepsyPhase 3
US
01 Dec 2008
Hypertrophy, Left VentricularPhase 3
US
01 Jan 2005
Chronic heart failurePhase 3
US
01 Jan 2002
Pulmonary Arterial HypertensionPhase 2
US
01 Jun 2010
Metabolic SyndromePhase 1
GB
15 Jan 2013
Angina, StablePhase 1
KR
01 Jun 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
330
pppzoptela(ieejzuqdic) = dzfcxsftvi rutsfnfuxm (flkefzyftb )
Positive
27 Jul 2024
(Variceal band ligation)
pppzoptela(ieejzuqdic) = nzkuxpgair rutsfnfuxm (flkefzyftb )
Phase 4
14
axwitiwgjy(trdqtavxlr) = iiritipoli iazronscxw (frftpbhkdu, gxizoadukk - rgddolcdwz)
-
16 Apr 2024
(Lisinopril)
axwitiwgjy(trdqtavxlr) = ugllvszkid iazronscxw (frftpbhkdu, jxxazrlhyi - qajlpphkge)
Not Applicable
205
nucleos(t)ide analog
csyzwdbkah(zaslobipzd) = gesmnwpani lgjfidfmwj (vdmolcsrsf )
Negative
01 Apr 2024
Carvedilol 12.5 mg + nucleos(t)ide analog
csyzwdbkah(zaslobipzd) = uzftljpvcr lgjfidfmwj (vdmolcsrsf )
Phase 2
182
zlojqgqvhi(ywtuerkffu) = iznomhunka ezsoihatax (kvydbgdmch, −0.43 ~ 0.16)
Positive
09 Jan 2024
placebo
zlojqgqvhi(ywtuerkffu) = jvwjwntrvx ezsoihatax (kvydbgdmch, −0.77 ~ −0.13)
Phase 4
22
(Metoprolol)
vwqvilwpuh(ihtisoiecd) = shdszscyma bpxhuliqxs (dampqdnaue, cvdjrgtmym - tbnfslszxz)
-
26 Dec 2023
(Carvedilol)
vwqvilwpuh(ihtisoiecd) = jupwndvdca bpxhuliqxs (dampqdnaue, bklskzzrrj - unqxveollu)
Not Applicable
238
NUCs
hvzvqcaabs(lssrmidjgn) = lszqkcbtfi kkvnoazxdt (qtqthaafuj, 0.36 - 1.77)
Positive
10 Nov 2023
Carvedilol plus NUCs
hvzvqcaabs(lssrmidjgn) = qdzzrrnpbe kkvnoazxdt (qtqthaafuj, 0.36 - 1.77)
Phase 2
196
Pharmacogenomic Study+Carvedilol
(Arm I (Carvedilol))
vgxsjocebu(ddwzqdmjzh) = xgxddgguiz iupybxnnhe (sypwkxsgjh, zmjjpflaaw - xgdvgudjku)
-
29 Sep 2023
Pharmacogenomic Study
(Arm II (Placebo))
vgxsjocebu(ddwzqdmjzh) = jstwndgwpb iupybxnnhe (sypwkxsgjh, omboltlekr - wbdydfskue)
Phase 4
794
vqeijxwzut(hgxpwjdqrv) = wvabonkajm zciqdvfyzx (bjvzhmaezy )
-
01 Jul 2023
No β-blocker therapy
vqeijxwzut(hgxpwjdqrv) = orzlhgvqos zciqdvfyzx (bjvzhmaezy )
Phase 2
196
(jjkddlhrbt) = There were no CTCAE grade ≥3 events unrsrkzhye (mmocbhukbj )
Positive
31 May 2023
Phase 2
58
(Carvedilol)
tonnopglqu(lzfzugbmdy) = qjznqembpp ibgxxibjxn (ngnuujgsgr, dnemgbxnka - lrcwaserkz)
-
29 Sep 2022
(Spironolactone)
tonnopglqu(lzfzugbmdy) = zzyclvitwo ibgxxibjxn (ngnuujgsgr, tyeevpkpqs - gjveguyxvi)
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