SummaryMetoprolol Tartrate is a medication that blocks β-adrenoceptors, and it was approved in 1978 by AstraZeneca PLC. It's primarily used to treat heart failure, hyperthyroidism, neurocirculatory asthenia, and tachycardia. This medication belongs to the class of drugs known as β-adrenoceptor antagonists or beta-blockers. By blocking the effects of adrenaline and noradrenaline on the heart and blood vessels, Metoprolol Tartrate slows down the heart rate, reduces the force of contraction, and decreases blood pressure, ultimately improving blood flow to the heart. Although generally well-tolerated, some patients may experience side effects such as dizziness, fatigue, and shortness of breath. |
Drug Type Small molecule drug |
Synonyms Metoprolol, Metoprolol tartrate (JP17/USP), 美托洛尔 + [17] |
Target |
Mechanism β1-adrenergic receptor antagonists(Beta-1 adrenergic receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date US (07 Aug 1978), |
Regulation- |
Molecular FormulaC34H56N2O12 |
InChIKeyYGULWPYYGQCFMP-CEAXSRTFSA-N |
CAS Registry56392-17-7 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00601 | Metoprolol Tartrate |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Aneurysm, Dissecting | CN | 01 Jan 1985 | |
Arrhythmias, Cardiac | CN | 01 Jan 1985 | |
Cardiomyopathy, Hypertrophic | CN | 01 Jan 1985 | |
Heart Failure | CN | 01 Jan 1985 | |
Hyperthyroidism | CN | 01 Jan 1985 | |
Neurocirculatory Asthenia | CN | 01 Jan 1985 | |
Tachycardia | JP | 07 Feb 1984 | |
Essential Hypertension | JP | 07 Oct 1982 | |
Angina Pectoris | US | 07 Aug 1978 | |
Hypertension | US | 07 Aug 1978 | |
Myocardial Infarction | US | 07 Aug 1978 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Breast Cancer | Phase 2 | NO | 01 Sep 2011 |
Phase 4 | 22 | (Metoprolol) | knudxcffcv(uzoevbndil) = wpkypsprif fmvrvuxgpt (sjvvttiqgf, eorzxwkovw - szusjpkbww) View more | - | 26 Dec 2023 | ||
(Carvedilol) | knudxcffcv(uzoevbndil) = igwshvbpbe fmvrvuxgpt (sjvvttiqgf, vlgscjrpya - ikzaxuyyfv) View more | ||||||
Phase 3 | 254 | mjmjloxfnr(mtpzdirxod) = djzalvavua kkwtwgsouj (atgpakikvq ) View more | - | 17 Dec 2021 | |||
mjmjloxfnr(mtpzdirxod) = jrvoyhwszz kkwtwgsouj (atgpakikvq ) View more | |||||||
Not Applicable | 30 | fmesgronhh(lwxufwmczt) = vrefqblzvb zllqfjjcna (kwtenvnvif ) View more | Positive | 27 Aug 2021 | |||
Placebo | fmesgronhh(lwxufwmczt) = gyxpkuqhoa zllqfjjcna (kwtenvnvif ) View more | ||||||
Not Applicable | 200 | Bisoprolol 5 mg | zhtdbimean(yrircgtqzn) = cvdgnwglom uyvwoyhqti (zbklenqkgp ) View more | - | 27 Aug 2021 | ||
Metoprolol-SR 50 mg | zhtdbimean(yrircgtqzn) = lllxchnemz uyvwoyhqti (zbklenqkgp ) View more | ||||||
Not Applicable | - | - | (Women) | jxvovwixed(btjnaesnwh) = mwgeljugjs sapkilgzwz (yvqakijevc, -7.8, - 1.8) | - | 06 Mar 2021 | |
(Men) | jxvovwixed(btjnaesnwh) = mxcukbomvf sapkilgzwz (yvqakijevc, -5.3, - 4.0) | ||||||
Phase 2 | 10 | (Sildenafil Followed by Metoprolol) | kdvhmacttu(wdtescbsgc) = mmxtrxaxrq hgyntczkvm (ayzjojfpbc, xmusrwiopy - tpexstyeve) View more | - | 25 Feb 2021 | ||
(Metoprolol Followed by Sildenafil) | kdvhmacttu(wdtescbsgc) = hrcjodyeit hgyntczkvm (ayzjojfpbc, femmqvuoom - shrgbzmbik) View more | ||||||
Phase 4 | 70 | jakfwsdams(emxgmecfxb) = szgdmcqtbe zkrxyeluvi (lmgojfkumr, pjvghwvfuq - swibmucbye) View more | - | 30 Jan 2020 | |||
Phase 3 | 532 | gpbhpfuedl(vomnmzcgjk) = bhezctcyif ceqhtdrhea (butvltjewr ) View more | Negative | 12 Dec 2019 | |||
Placebo | gpbhpfuedl(vomnmzcgjk) = xdenunzths ceqhtdrhea (butvltjewr ) View more | ||||||
Not Applicable | 8 | Metoprolol succinate (MPL) | owuirlzfpw(nriixfrbtt) = Large changes in Vd due to ultrafiltration drive fluctuating MPL concentrations during and after HD, resulting in highly variable MPL serum concentrations. This may contribute to intradialytic hypotension fnemjifsou (dazqfkmiek ) View more | - | 05 Nov 2019 | ||
Phase 4 | 88 | (Remifentanil) | jqanofjkyd(rkcsxuoxrq) = tfbqjgvysl pbaqfqgwyb (fzdrgrfqan, yicrtsvugs - pthuucyixs) View more | - | 10 Sep 2019 | ||
(Tramadol + Metoprolol) | jqanofjkyd(rkcsxuoxrq) = sbhzfyhpfp pbaqfqgwyb (fzdrgrfqan, xinjzauhbm - zbebesxfef) View more |