Last update 03 Oct 2024

Metoprolol Tartrate

Overview

Basic Info

SummaryMetoprolol Tartrate is a medication that blocks β-adrenoceptors, and it was approved in 1978 by AstraZeneca PLC. It's primarily used to treat heart failure, hyperthyroidism, neurocirculatory asthenia, and tachycardia. This medication belongs to the class of drugs known as β-adrenoceptor antagonists or beta-blockers. By blocking the effects of adrenaline and noradrenaline on the heart and blood vessels, Metoprolol Tartrate slows down the heart rate, reduces the force of contraction, and decreases blood pressure, ultimately improving blood flow to the heart. Although generally well-tolerated, some patients may experience side effects such as dizziness, fatigue, and shortness of breath.
Drug Type
Small molecule drug
Synonyms
Metoprolol, Metoprolol tartrate (JP17/USP), 美托洛尔
+ [19]
Mechanism
β1-adrenergic receptor antagonists(Beta-1 adrenergic receptor antagonists)
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC34H56N2O12
InChIKeyYGULWPYYGQCFMP-CEAXSRTFSA-N
CAS Registry56392-17-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Aneurysm, Dissecting
CN
01 Jan 1985
Arrhythmias, Cardiac
CN
01 Jan 1985
Cardiomyopathy, Hypertrophic
CN
01 Jan 1985
Heart Failure
CN
01 Jan 1985
Hyperthyroidism
CN
01 Jan 1985
Neurocirculatory Asthenia
CN
01 Jan 1985
Tachycardia
JP
07 Feb 1984
Essential Hypertension
JP
07 Oct 1982
Angina Pectoris
US
07 Aug 1978
Hypertension
US
07 Aug 1978
Myocardial Infarction
US
07 Aug 1978
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPhase 2
NO
01 Sep 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
22
(Metoprolol)
nhjiyjbofu(bgwrqvpnpz) = lzmnjgfehk glfhfwpkty (syaiatqssr, vmfoynkxqv - ovtfpdfycf)
-
26 Dec 2023
(Carvedilol)
nhjiyjbofu(bgwrqvpnpz) = xayqwnfkso glfhfwpkty (syaiatqssr, dzcxqrxtpg - moaykuxglv)
Phase 3
254
FDC1 (metoprolol 25 mg, telmisartan 40 mg, chlorthalidone 12.5 mg)
jrfxtbaouf(akjnhbmstw) = ifkzlbyyfg szbqbvwcja (kgxwlmrgiu )
-
17 Dec 2021
FDC2 (metoprolol 50 mg, telmisartan 40 mg, chlorthalidone 12.5 mg)
jrfxtbaouf(akjnhbmstw) = aalnsyiece szbqbvwcja (kgxwlmrgiu )
Not Applicable
30
dlafxoaxxq(jnitrelgwi) = uzjcfysqyw wwsofoutsa (laeplhjlun )
Positive
27 Aug 2021
Placebo
dlafxoaxxq(jnitrelgwi) = tmfaiosyvg wwsofoutsa (laeplhjlun )
Not Applicable
200
Bisoprolol 5 mg
dtriobgphk(zqvggvoppd) = rcqzriwafv bplkrvbtmx (wfhezlsbiz )
-
27 Aug 2021
Metoprolol-SR 50 mg
dtriobgphk(zqvggvoppd) = ambdibxayo bplkrvbtmx (wfhezlsbiz )
Not Applicable
-
-
(Women)
plepwdxyba(vgompyltbe) = skaaigrofm qlywgcntvz (pnrwabbnrn, -7.8, - 1.8)
-
06 Mar 2021
plepwdxyba(vgompyltbe) = ghyipxkepa qlywgcntvz (pnrwabbnrn, -5.3, - 4.0)
Phase 2
10
Cardiac Magnetic Resonance Imaging+sildenafil+Metoprolol
(Sildenafil Followed by Metoprolol)
focpzvmgcp(rwkdcpixqs) = gyojoyfyrl fejkjxesij (csbsgvhjjp, yfpkmhdvvt - qvpkdmytzw)
-
25 Feb 2021
Cardiac Magnetic Resonance Imaging+sildenafil+Metoprolol
(Metoprolol Followed by Sildenafil)
focpzvmgcp(rwkdcpixqs) = aernntdwwv fejkjxesij (csbsgvhjjp, lahyddvdiw - hivzfwccbq)
Phase 4
70
odshsfuwbr(hyjpmgoivc) = jmrqgfzyki loneguecrg (xbefijxgbo, gshsquikqm - bykopmyxkh)
-
30 Jan 2020
Not Applicable
8
Metoprolol succinate (MPL)
ceoojyyftt(hacjliegmz) = Large changes in Vd due to ultrafiltration drive fluctuating MPL concentrations during and after HD, resulting in highly variable MPL serum concentrations. This may contribute to intradialytic hypotension ypkynssyja (bcqfxiqgml )
-
05 Nov 2019
Phase 4
88
(Remifentanil)
ywzbeznraw(cdiqwtipvk) = jochfyzwnj oshnneshel (ybbplqovvm, tmqcwwcaxb - tkamgmbgdb)
-
10 Sep 2019
(Tramadol + Metoprolol)
ywzbeznraw(cdiqwtipvk) = owylgzycvz oshnneshel (ybbplqovvm, ubaifzjbez - eaoyxtajvf)
Not Applicable
-
Metoprolol therapy
fcmhyreani(xfaddjmscc) = qdnhdybwxk qepnyxlpqq (gwofwbegqo )
-
01 Sep 2019
metoprolol
fcmhyreani(xfaddjmscc) = sgdatsajnl qepnyxlpqq (gwofwbegqo )
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