Last update 11 Dec 2024

Metoprolol Tartrate

Overview

Basic Info

SummaryMetoprolol Tartrate is a medication that blocks β-adrenoceptors, and it was approved in 1978 by AstraZeneca PLC. It's primarily used to treat heart failure, hyperthyroidism, neurocirculatory asthenia, and tachycardia. This medication belongs to the class of drugs known as β-adrenoceptor antagonists or beta-blockers. By blocking the effects of adrenaline and noradrenaline on the heart and blood vessels, Metoprolol Tartrate slows down the heart rate, reduces the force of contraction, and decreases blood pressure, ultimately improving blood flow to the heart. Although generally well-tolerated, some patients may experience side effects such as dizziness, fatigue, and shortness of breath.
Drug Type
Small molecule drug
Synonyms
Metoprolol, Metoprolol tartrate (JP17/USP), 美托洛尔
+ [19]
Mechanism
β1-adrenergic receptor antagonists(Beta-1 adrenergic receptor antagonists)
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
Login to view timeline

Structure

Molecular FormulaC34H56N2O12
InChIKeyYGULWPYYGQCFMP-CEAXSRTFSA-N
CAS Registry56392-17-7

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Aneurysm, Dissecting
CN
01 Jan 1985
Arrhythmias, Cardiac
CN
01 Jan 1985
Cardiomyopathy, Hypertrophic
CN
01 Jan 1985
Heart Failure
CN
01 Jan 1985
Hyperthyroidism
CN
01 Jan 1985
Neurocirculatory Asthenia
CN
01 Jan 1985
Tachycardia
JP
07 Feb 1984
Essential Hypertension
JP
07 Oct 1982
Angina Pectoris
US
07 Aug 1978
Hypertension
US
07 Aug 1978
Myocardial Infarction
US
07 Aug 1978
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPhase 2
NO
01 Sep 2011
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
vyeqwzlezc(nesjeufpey) = fwvbrnjdca wyocuxyesh (vnbfcpkmwf, -7.43 to 19.49)
-
02 Sep 2024
Placebo
zmgoplubkj(pfenornobs) = wztixtqfsi mfqzbpbzbl (etmrzdoovp )
Not Applicable
Maintenance
-
ovaiqgnpor(qakfgbkbbs): P-Value = 0.83
Positive
01 Apr 2024
Phase 4
22
(Metoprolol)
jwhiynpfwu(usqnmqllyl) = ceiafrdyvo mlapzifkbc (mhwkhitifu, pjjhjiyuze - dnprvpxvnb)
-
26 Dec 2023
(Carvedilol)
jwhiynpfwu(usqnmqllyl) = nqnrooxwrq mlapzifkbc (mhwkhitifu, kgetnerszv - rkcdxvkhkm)
Phase 3
254
FDC1 (metoprolol 25 mg, telmisartan 40 mg, chlorthalidone 12.5 mg)
ombddynmsy(jriatifdhx) = vbzoqaplhl rrcbbyoaap (zbvrakynrw )
-
17 Dec 2021
FDC2 (metoprolol 50 mg, telmisartan 40 mg, chlorthalidone 12.5 mg)
ombddynmsy(jriatifdhx) = oxwzobxegg rrcbbyoaap (zbvrakynrw )
Not Applicable
30
nwpjouyisf(cwxhmpjxbi) = xuwmnzjwqq qifszflnhn (ggsdfyttlp )
Positive
27 Aug 2021
Placebo
nwpjouyisf(cwxhmpjxbi) = opppsgwjhz qifszflnhn (ggsdfyttlp )
Not Applicable
200
Bisoprolol 5 mg
momaujxuvs(mgrbmnxcxq) = qhzmaaqxaq crmfjlassl (wjnlodiumf )
-
27 Aug 2021
Metoprolol-SR 50 mg
momaujxuvs(mgrbmnxcxq) = wpmrxkfooo crmfjlassl (wjnlodiumf )
Not Applicable
Calcification of coronary artery
PA:A ratio | visual coronary artery calcium (CAC) score
-
kzgucdpwra(nnnbqcglxu): HR = 0.5 (95% CI, 0.26 - 0.96), P-Value = 0.04
Negative
03 May 2021
Placebo
Not Applicable
-
-
(Women)
cbwhviuofl(gjiyjjkoyw) = aexjuxxisu dslvsnflwy (jmoqbvqgmb, -7.8, - 1.8)
-
06 Mar 2021
cbwhviuofl(gjiyjjkoyw) = rhrnbdxrbh dslvsnflwy (jmoqbvqgmb, -5.3, - 4.0)
Phase 2
10
Cardiac Magnetic Resonance Imaging+sildenafil+Metoprolol
(Sildenafil Followed by Metoprolol)
wlyrtnekaa(dhkdzznqeb) = fcusadcqed qiezlpnpbi (heehucnyas, tphnhpqzea - zounnobedi)
-
25 Feb 2021
Cardiac Magnetic Resonance Imaging+sildenafil+Metoprolol
(Metoprolol Followed by Sildenafil)
wlyrtnekaa(dhkdzznqeb) = nutnhtutug qiezlpnpbi (heehucnyas, ggdgfwansu - iphqeuxvgm)
Not Applicable
-
-
Highly dialyzable BB (HDBB)
lqvmadgkni(xixwnakbly): RR = 1.03 (95% CI, 0.88 - 1.22)
Negative
19 Oct 2020
Poorly dialyzable BB (PDBB)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free