Last update 04 Nov 2024

HSK-31858

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
HSK 31858, HSK31858
Target
Mechanism
DPP-1 inhibitors(Cathepsin C inhibitors)
Inactive Indication-
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationBreakthrough Therapy (CN)
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-cystic fibrosis bronchiectasisPhase 3
CN
26 Sep 2024
AsthmaPhase 2
CN
22 Oct 2024
Acute Lung InjuryPhase 1
CN
25 Oct 2024
Respiratory Distress Syndrome, AcutePhase 1
CN
25 Oct 2024
Pulmonary Disease, Chronic ObstructiveIND Approval
CN
10 Apr 2024
Lower Respiratory Tract InfectionsIND Approval
CN
28 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
epxcxdvome(ylsjalbztp) = HSK31858 was absorbed rapidly, with no significant accumulation of Cmax, while AUC accumulation was more pronounced. There was dose-dependent inhibitory effect in whole blood NE activity, with maximum inhibition of 13.6%, 44.1%,and 76.4% in the 10mg,20mg, and 40mg groups, repectively. pclcsgvapx (ufvohppurh )
Positive
09 Sep 2023
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Regulation

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