Last update 01 Nov 2024

E-7386

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms-
Mechanism
CREBBP inhibitors(cAMP-response element binding protein inhibitors), CTNNB1 inhibitors(Catenin beta 1 inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC39H48FN9O4
InChIKeyZGNKNLOBYFTGRG-GIWKVKTRSA-N
CAS Registry1799824-08-0

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MelanomaPhase 2
US
27 Oct 2021
MelanomaPhase 2
JP
27 Oct 2021
MelanomaPhase 2
ES
27 Oct 2021
MelanomaPhase 2
GB
27 Oct 2021
Colorectal CancerPhase 2
US
11 Jul 2019
Colorectal CancerPhase 2
JP
11 Jul 2019
Colorectal CancerPhase 2
FR
11 Jul 2019
Colorectal CancerPhase 2
KR
11 Jul 2019
Colorectal CancerPhase 2
TW
11 Jul 2019
Endometrial CarcinomaPhase 2
US
11 Jul 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
16
xhvyxylskj(mkmcgqptje) = nmfdnznfuc rqoiexspfj (hgtgfxywll )
Positive
14 Sep 2024
Phase 1
Advanced Hepatocellular Carcinoma
TERT Mutation | TP53 Mutation | CTNNB1 Mutation ...
22
(β-catenin expression)
kuxwtpywaw(qkdeuatujh) = jkvbzujcqc wzaxpjrvjx (uucjcqmigm )
Positive
18 Jan 2024
(without β-catenin expression)
kuxwtpywaw(qkdeuatujh) = dvppctnhcf wzaxpjrvjx (uucjcqmigm )
Phase 1
25
xqgoixjqpx(xizprzijli) = sldyumjbrs jikcvlgiru (szezkqnhaa )
Positive
26 May 2023
Phase 1
36
zbicfzupfy(lkbeiqkrau) = vkodikfhyv nvxqcafyxh (yrtoexinns )
Positive
24 Jan 2023
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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