Last update 24 Apr 2025

E-7386

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms-
Action
inhibitors
Mechanism
CREBBP inhibitors(cAMP-response element binding protein inhibitors), CTNNB1 inhibitors(Catenin beta 1 inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC39H48FN9O4
InChIKeyZGNKNLOBYFTGRG-GIWKVKTRSA-N
CAS Registry1799824-08-0

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Endometrial CarcinomaPhase 2
United States
13 Dec 2024
Endometrial CarcinomaPhase 2
Japan
13 Dec 2024
Endometrial CarcinomaPhase 2
Canada
13 Dec 2024
Endometrial CarcinomaPhase 2
Denmark
13 Dec 2024
Endometrial CarcinomaPhase 2
France
13 Dec 2024
Endometrial CarcinomaPhase 2
Italy
13 Dec 2024
Endometrial CarcinomaPhase 2
South Korea
13 Dec 2024
Endometrial CarcinomaPhase 2
Spain
13 Dec 2024
Colorectal CancerPhase 2
United Kingdom
27 Oct 2021
Hepatocellular CarcinomaPhase 2
United Kingdom
27 Oct 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
16
vdefmequvl(wkkuyhdqkf) = yrwrtqfpyq maxvprlotl (ewnwskqlox )
Positive
14 Sep 2024
Phase 1
Advanced Hepatocellular Carcinoma
TERT Mutation | TP53 Mutation | CTNNB1 Mutation ...
22
(β-catenin expression)
bosbvwbepb(eqspnvznbk) = wagmnujhec swbixdmulp (yrxweqeclw )
Positive
18 Jan 2024
(without β-catenin expression)
bosbvwbepb(eqspnvznbk) = qxfqmtbpvi swbixdmulp (yrxweqeclw )
Phase 1
25
puthvkmzaf(zlmpvgegaa) = xyfickmudf xrxtnwoebx (mqqnbzrpol )
Positive
26 May 2023
Phase 1
36
imjgamebjv(gbbtvmpxyl) = ugpqiwmmts hgbwwjwcxq (cnunqwhdze )
Positive
24 Jan 2023
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Approval

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Regulation

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