This is an intent-to-treat, split-plot design, multicenter randomized trial and the primary intervention is a double-blind comparison of Imiquimod (IMQ) vs. placebo cream for preventing basal cell carcinoma (BCC) of the skin on the face at one year and over 3 years after therapy. Participants will apply the IMQ or placebo cream to the face daily at bedtime for 12 weeks. This study will recruit 1630 Veterans at high risk of BCC from 17 VA medical centers.

Start Date15 Jan 2025

Sponsor / Collaborator

VA Office of Research and Development

NCT06686043 / RecruitingPhase 2IIT

A Phase 2 Study of HPV L1 Vaccine in Combination With Imiquimod and Metformin in Cervical, Vaginal, and Vulvar Cancers

The goal of this clinical trial is to explore whether additional treatments can help strengthen the participant's immune system to fight cancer caused by the Human Papillomavirus (HPV), a virus spread through intimate skin-to-skin contact. The trial will also monitor the safety of these treatments. The main questions it aims to answer are:
Does the combination of treatments help the participant's body fight the cancer more effectively when used alongside standard therapy? What side effects or medical issues arise when using these experimental treatments? Researchers will use three experimental therapies along with the participant's standard treatment to find out if these therapies work better together than standard treatment alone.
Participants will:
Receive HPV vaccinations during the 2nd and 4th week of radiation, and again at weeks 8, 10, 12, and 16 after completing radiation.
Have blood samples taken, tumor cells brushed from the surface, and imiquimod cream applied during each visit.
Take a daily metformin pill and apply an imiquimod suppository three times a week for two weeks after each visit.

Start Date23 Aug 2024

Sponsor / Collaborator

Baylor College of Medicine

[+2]

RBR-3j6jwg3 / RecruitingPhase 3IIT

Randomized clinical trial to evaluate the efficacy and safety of Intralesional Meglumine Antimoniate associated with topical Imiquimod in the treatment of Cutaneous Leishmaniasis

Start Date20 Jun 2024

Sponsor / Collaborator-

100 Clinical Results associated with Imiquimod

100 Translational Medicine associated with Imiquimod

100 Patents (Medical) associated with Imiquimod

4,596

Literatures (Medical) associated with Imiquimod

01 Jan 2025·Journal of Colloid and Interface Science

A nanodrug provokes antitumor immune responses via synchronous multicellular regulation for enhanced cancer immunotherapy

Article

Author: Cao, Jianrong ; Huang, Guohong ; Hong, Keze ; Deng, Wei ; Jiang, Weiting ; Fang, Jin ; Huang, Tao ; Wang, Yong

Hepatocellular carcinoma (HCC) exhibits a low response to immunotherapy due to the dense extracellular matrix (ECM) filled with immunosuppressive cells including dendritic cells (DCs) of blocked maturation. Herein, we develop a nanoprodrug self-assembled from polyethylene glycol-poly-4-borono-l-phenylalanine (mPEG-PBPA) conjugating with quercetin (QUE) via boronic ester bonds. In addition, an immune adjuvant of imiquimod (R837) is incorporated. The nanodrug (denoted as Q&R@NPs) is prepared from a simple mixing means with a high loading content of QUE reaching more than 30%. Owing to the acid and reactive oxygen species (ROS) sensitivities of boronic ester bonds, Q&R@NPs can respond to the tumor microenvironment (TME) and release QUE and R837 to synchronously exert multicellular regulation functions. Specifically, QUE inhibits the activation state of hepatic stellate cells and reduces highly expressed programmed death receptor ligand 1 (PD-L1) on tumor cells, meanwhile R837 exposes calreticulin on tumor cell surface as an "eat me" signal and leads to a large number of DCs maturing for enhanced antigen presentation. Consequently, the cooperative immune regulation results in a remodeled TME with high infiltration of cytotoxic T lymphocytes for enhanced HCC immunotherapy, which demonstrates an effective immunotherapy paradigm for dense ECM characterized solid tumors with high PD-L1 expression.

01 Jan 2025·Brain, Behavior, and Immunity

An initial investigation of transcutaneous delivery of plasmid DNA encoding interleukin-10 for the treatment of psoriatic skin conditions

Article

Author: Watkins, Linda R. ; Harland, Michael E. ; Rafael Correia Rocha, Igor ; Ball, Jayson B ; Watkins, Linda R ; Finch, Maggie R ; Liu, Yi ; Harland, Michael E ; Finch, Maggie R. ; Clements, Madison ; Banov, Daniel ; Song, Guiyun ; Green-Fulgham, Suzanne ; Ball, Jayson B.

Psoriasis is a chronic immune-mediated skin disorder characterized by intense local inflammation, epidermal hyperplasia, and leukocyte infiltration. Current treatment approaches for psoriasis aim to alleviate symptoms and prevent disease progression, including systemically administered drugs with whole body side effects. Despite some advances in psoriasis treatment, success has been quite limited. To begin to address this challenge, we undertook an initial investigation of whether transcutaneous delivery of an endogenous anti-inflammatory cytokine could provide an effective, local treatment of psoriatic-like skin conditions. To do this, we utilized a previously documented rodent model of psoriasis, induced via a single topical application of Imiquimod (IMQ) to the shaved back of rats. The therapeutic approach used for this initial investigation was delivery of plasmid DNA encoding rat interleukin-10 (pDNA-rIL10), a non-viral gene therapy approach previously shown to be effective in suppressing neuroinflammatory disorders after localized delivery either intracerebrally or intrathecally. Translation of this CNS therapeutic for use in psoriatic-like skin disorders required reformulation to enable transcutaneous delivery. Toward that end, pDNA-rIL10 was topically applied in Lipoderm HMW, a base explicitly designed to deliver higher molecular weight compounds into skin. Here we show that a single topical application of pDNA-rIL10 in Lipoderm HMW was effective in decreasing mRNA levels of pro-inflammatory cytokines as well as reducing the recruitment of T-cells to IMQ-treated skin. Furthermore, this transcutaneous IL-10 gene therapy decreased signs of skin inflammation, reflected by reduced erythema. Moreover, the results provide an initial indication that IL10 may stimulate hair regrowth in psoriatic-like skin.

01 Jan 2025·Journal of Ethnopharmacology

Metabolic reprogramming and AMPK activation: Key players in the therapeutic effects of Cooling Blood and Detoxicating Formular on psoriasis

Article

Author: Yang, Danyang ; Li, Ping ; Meng, Yujiao ; Zhao, Jingxia ; Wang, Yazhuo ; Zhang, Xiawei ; Zhu, Haoyue ; Ma, Huike ; Wang, Yan ; Di, Tingting ; Chen, Jia ; Zhao, Ning ; Ma, Yueyue ; Qu, Baoquan ; Li, Lin

ETHNOPHARMACOLOGICAL RELEVANCECooling Blood and Detoxicating Formular (CBDF) based on the theory of cooling blood and dosing detoxification, is a useful traditional Chinese medicine (TCM) medication for psoriasis with blood-heat syndrome.AIM OF THE STUDYInvestigate the active constituents and mechanisms of the CBDF for the treatment of psoriasis.MATERIALS AND METHODSUPLC-Q-Orbitrap-HRMS technique was used to analyse the ingredients of CBDF absorbed into plasma and skin tissue. The therapeutic efficacy of CBDF was evaluated in treating an imiquimod (IMQ)-induced mouse model was assessed. Transcriptome analysis and gene enrichment analysis were used to explore the changes in gene expression and pathways following treatment with the CBDF. Validation was performed using western blotting, quantitative RT-PCR, flow cytometry, gene knockout and molecular docking in vitro and in vivo.RESULTS26 compounds were identified in the plasma of IMQ-induced psoriasis-like mouse with CBDF treatment, and higher levels of cimifugin in the lesion. CBDF improved the pathological changes of psoriasis, with inhibition of TNF-α, IL-23, and IL-17A and upregulation of IL-10. Gene enrichment analysis showed that the therapeutic effect of CBDF was related to AMPK pathway. In psoriasis lesions, the AMPK and fatty acid oxidation were suppressed, and glycolysis was enhanced. The Prkaa2, encoding AMPKα2 was down-regulated in psoriasis patients. CBDF inhibited glycolysis while stimulating fatty acid oxidation by the activating AMPK, thereby exerting an inhibitory effect on inflammation. CBDF inhibited MHCII, CD80, and CD86 on dendritic cells of skin drainage lymph node. In vitro, CBDF inhibited bone marrow-derived DCs secrete IL-23, TNF-α, and lactate, while enhanced fatty acid oxidation and AMPK activity. However, the therapeutic effect was weakened in AMPKα2 deletion. Additionally, psoriasis lesions and dendritic cells activation were significantly aggravated after AMPKα2 knockout. The key ingredients of the CBDF, cimifugin, rutin, astilbin, quercetin, and prim-O-glucosylcimifugin, all exhibit a notable affinity towards AMPKα2 binding.CONCLUSIONSCBDF ameliorates psoriasis symptoms and inhibit dendritic cells maturation by regulating metabolic reprogramming in an AMPK-dependent mechanism.

News (Medical) associated with Imiquimod

02 Jul 2024

·www.globenewswire.com

Artelo Biosciences Announces Data Supporting Broad Potential Utility of its FABP Inhibitor Platform

Inhibition of FABP5 Demonstrates Activity in Cancer, Psoriasis, and Anxiety Disorders Results from Several Research Studies Presented at the Annual ICRS Symposium SOLANA BEACH, Calif., July 02, 2024 (GLOBE NEWSWIRE) -- Artelo Biosciences, Inc. (Nasdaq: ARTL), a clinical-stage pharmaceutical company focused on modulating lipid-signaling pathways to develop treatments for people living with cancer, pain, dermatologic and neurological conditions, today announced that George Warren, Ph.D., Principal Scientist at Artelo, Myles Osborn, Medicinal Chemist at Artelo, and Matthew Jones, Ph.D. candidate from the Laviolette laboratory at the University of Western Ontario, Canada, each presented results from research studies demonstrating the broad therapeutic potential of Fatty Acid Binding Protein 5 (FABP5) inhibition at the 34th Annual International Cannabinoid Research Society (ICRS) Symposium. The ICRS Symposium is being held June 30 – July 5, 2024 in Salamanca, Spain. Targeting FABP5, a promising new approach to treat cancer, was featured in the presentation “Efficacy of ART26.12, a Novel Fatty Acid Binding Protein 5 Inhibitor, in an Orthotopic HCT-116-LUC Human Colon Cancer Model.” Myles Osborn discussed novel preclinical data showing a direct anti-tumoral effect of oral treatment with ART26.12. These data are also supportive of Artelo’s planned development of ART26.12 in chemotherapy-induced peripheral neuropathy, where ART26.12 may be able to aid in treatment of the underlying cancer, in addition to the debilitating effects of painful neuropathies. Beyond development for pain and cancer, ART26.12 has also shown the potential for therapeutic activity in dermatologic conditions. FABP5 was first identified in psoriatic lesions and there is evidence to suggest that upregulation of FABP5 contributes to the pathology of psoriasis. Regarding the data in his presentation, “A Novel Fatty Acid-binding Protein 5 Inhibitor Shows Efficacy in Preclinical Models of Psoriasis,” George Warren, Ph.D. commented, “We are pleased to share novel data showing that our lead FABP5 inhibitor, ART26.12, demonstrated compelling data in preclinical models of psoriasis. In this study, ART26.12 reduced the severity of histopathological markers of skin damage and reduced markers of oxidative stress, chemokines, cytokines, and keratinocyte proliferation, and increased antimicrobial peptides. Results were obtained using a standard imiquimod mouse model, which demonstrated ART26.12 had similar levels of activity as Sotyktu (deucravacitinib), an oral tyrosine kinase 2 inhibitor approved by the U.S. Food and Drug Administration in 2022 to treat psoriasis. Sales of Sotyktu may reach $4 billion by the end of the decade, according to Bristol Myers Squibb.” In addition to ART26.12, another one of Artelo’s FABP5 inhibitors was featured in a presentation entitled, “Inhibition of Fatty Acid Binding Protein 5 Prevents Stress-induced Anxiety and Depressive-Like Behavioral Symptoms and Reverses Stress-induced Inhibition of Hippocampal Neurogenesis” where Matthew Jones discussed new results from ongoing studies being conducted at the laboratory of Dr. Steven Laviolette. The data showed that Artelo’s FABP5 inhibitor SBFI103 improved depressive-like behaviors in rats after chronic unpredictable stress, associated with increases in markers of neurogenesis, a critical process in which newly formed neural cells are added to the existing neural network. “This new data supports our laboratory’s earlier work showing SBFI103 reduces anxiety and increased fear memory extinction. These studies implicate a role for the cannabinoid receptor 2 mediating the effects of FABP5 inhibition in the brain,” concluded Jones. “We are pleased to share the expanding evidence for the potential utility of inhibiting FABP5,” stated Gregory D. Gorgas, President and Chief Executive Officer of Artelo. “These important scientific advances show that lipid modulation is a promising therapeutic strategy across multiple diseases where overactivity of the lipidome contributes to the pathology of the disease or where modulation of the lipidome leads to increased levels of analgesic and anxiolytic lipids. We are grateful for the opportunity to share our data and why we believe development of FABP5 inhibitors from our extensive library could have significant impact for a wide range of diseases. We expect to report on first-in-human trials with ART26.12 next year.” About ART26.12Fatty Acid Binding Proteins (FABPs) are a family of intracellular proteins that chaperone lipids including endocannabinoids and fatty acids. FABP is overexpressed and associated with abnormal lipid signaling in a number of pathologies. ART26.12, Artelo’s lead FABP inhibitor, is a potent and selective inhibitor of FABP5 being developed as a novel, peripherally acting, non-opioid, non-steroidal analgesic, with an initial clinical study planned for chemotherapy-induced peripheral neuropathy (CIPN). Beyond ART26.12, Artelo’s extensive library of small molecule inhibitors of FABPs have shown therapeutic promise for the treatment of certain cancers, neuropathic and nociceptive pain, and anxiety disorders. About the International Cannabinoid Research SocietyThe International Cannabinoid Research Society (ICRS) is the premier global scientific association with more than 650 international members from 40 countries, all active researchers in the field of endogenous, plant-derived, and synthetic cannabinoids and related bioactive lipids. In addition to acting as a source for impartial information on cannabis and the cannabinoids, the main role of the ICRS is to provide an open forum for researchers to meet and discuss their research. The ICRS Symposium is being held June 30 – July 5, 2024 in Salamanca, Spain. About Artelo Biosciences Artelo Biosciences, Inc. is a clinical stage pharmaceutical company dedicated to the development and commercialization of proprietary therapeutics that modulate lipid-signaling pathways including the endocannabinoid system. Artelo is advancing a portfolio of broadly applicable product candidates designed to address significant unmet needs in multiple diseases and conditions, including anorexia, cancer, anxiety, pain, and inflammation. Led by proven biopharmaceutical executives collaborating with highly respected researchers and technology experts, the company applies leading edge scientific, regulatory, and commercial discipline to develop high-impact therapies. For more information and to view available publications, please visit https://artelobio.com/science/. Forward Looking StatementsThis press release contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and Private Securities Litigation Reform Act, as amended, including those relating to the Company’s product development, clinical and regulatory timelines, market opportunity, competitive position, possible or assumed future results of operations, business strategies, potential growth opportunities and other statement that are predictive in nature. These forward-looking statements are based on current expectations, estimates, forecasts and projections about the industry and markets in which we operate and management’s current beliefs and assumptions. These statements may be identified by the use of forward-looking expressions, including, but not limited to, “expect,” “anticipate,” “intend,” “plan,” “believe,” “estimate,” “potential,” “predict,” “project,” “should,” “would” and similar expressions and the negatives of those terms. These statements relate to future events or our financial performance and involve known and unknown risks, uncertainties, and other factors which may cause actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Such factors include those set forth in the Company’s filings with the Securities and Exchange Commission, including our ability to raise additional capital in the future. Prospective investors are cautioned not to place undue reliance on such forward-looking statements, which speak only as of the date of this press release. The Company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise, except to the extent required by applicable securities laws. Investor Relations Contact:Crescendo Communications, LLCTel: 212-671-1020Email: ARTL@crescendo-ir.com

Drug ApprovalClinical Result

01 Jul 2024

·www.drugs.com

Few Patients With Positive Margins After Basal Cell Excision Have Recurrence

MONDAY, July 1, 2024 -- Among patients with incompletely excised basal cell carcinoma (BCC), only about 16 percent with positive histopathologic margins have clinical recurrence, according to a study published online June 13 in Dermatology . Maria Daviti, M.D., from Aristotle University in Thessaloniki, Greece, and colleagues reported the real-life management of incompletely excised BCC in a tertiary referral center and compared recurrence rates according to management modality in a retrospective study. All BCCs with available histopathologic assay reporting at least one involved margin (lateral or deep) over a five-year period were identified. Patients were categorized into three groups: immediate re-excision (group 1; 26 patients); follow-up without any additional treatment (group 2; 40 patients); and treatment with adjuvant/complementary nonsurgical treatment (group 3; 18 patients). The researchers found that based on histopathological reports, 53.8 percent of 26 tumors in group 1 that were re-excised had residual tumor. After a mean follow-up of 17 months, a clinical recurrence occurred in 14 of 84 patients (16.7 percent), with a median of 14 months to recurrence. Recurrence developed in 25 percent of the patients without any additional treatment, compared with 11.1 percent of those receiving nonsurgical treatments. "Our study suggests that positive histopathologic margins after BCC excision result in a clinical recurrence only in a proportion of patients," the authors write. "This percentage is higher when no further treatment is applied and lower when the area is re-excised or treated with imiquimod alone or combined with cryotherapy." Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

Clinical Result

13 Nov 2023

·www.sciencedaily.com

Researchers develop gel to deliver cancer drugs for solid tumors

Intratumoral therapy -- in which cancer drugs are injected directly into tumors -- is a promising treatment option for solid cancers but has shown limited success in clinical trials due to an inability to precisely deliver the drug and because most immunotherapies quickly dissipate from the site of injection. A team of researchers has developed a gel delivery system that overcomes these challenges. The gel is injectable but solidifies upon delivery; contains an imaging agent for visualization under CT scan; and can hold a high concentration of drug for slow, controlled release. Intratumoral therapy -- in which cancer drugs are injected directly into tumors -- is a promising treatment option for solid cancers but has shown limited success in clinical trials due to an inability to precisely deliver the drug and because most immunotherapies quickly dissipate from the site of injection. A team of researchers from Mass General Brigham, in collaboration with colleagues at the Koch Institute for Integrative Cancer Research, has developed a gel delivery system that overcomes these challenges. The gel is injectable but solidifies upon delivery; contains an imaging agent for visualization under CT scan; and can hold a high concentration of drug for slow, controlled release. In a paper published in Advanced Healthcare Materials, the team reports that using gel-delivered imiquimod (an immune stimulating drug) in combination with checkpoint inhibitor therapy induced tumor regression and increased survival in mouse models of colon and breast cancer that are usually resistant to checkpoint inhibitor therapy. The treatment also appeared to train the immune system to detect and attack distant tumors that were not directly treated, suggesting that it might be a helpful therapy for metastatic cancers. "This gel tackles the two problems with existing attempts at making intratumoral cancer immunotherapy: making the therapy visible and practical so that interventional radiologists can confirm delivery, and making sure the drug actually stays in the region of interest," said Avik Som, MD, PhD, of the Department of Radiology at Massachusetts General Hospital, a founding member of the Mass General Brigham healthcare system. "When we inject this gel into a tumor, we're able to teach the immune system to recognize the cancer and trigger it to attack not only the site where the gel was injected, but also other areas in the body where the same cancer may be hiding." The research team, which consisted of both engineers and medical professionals, first developed and optimized the gel-delivery system in the lab by tweaking the gel's chemical structure. One key aspect of the gel's design was that it needed to shift from being liquid at room temperature to make it injectable but become solid at body temperature inside the tumor in order to form a drug-releasing depot, while also retaining drug encapsulation and delivery capability, and carrying sufficient imaging agent. After optimizing the gel in the lab, the team tested its ability to treat mouse models of colon and breast cancer that are usually resistant to immunotherapy. To do this, they used the gel to deliver imiquimod, an FDA-approved immune stimulating drug, in combination with checkpoint inhibitor therapy. Each mouse had two tumors of the same type, but the researchers only treated one tumor per mouse, which allowed them to test the gel's ability to stimulate both local and systemic immunity. They showed that treating with gel-delivered imiquimod in combination with checkpoint inhibitor therapy improved survival in both cancer models. The treatment resulted in an all-or-nothing response -- mice that responded to the treatment showed complete regression of both the treated tumor and a distantly located tumor (a model for metastasis), while non-responders showed no regression at either site. For the colon cancer model, 46% (6/13) survived when the checkpoint inhibitor therapy was combined with gel-delivered imiquimod. For the breast cancer model, 20% (3/15) survived when treated with the combined therapies. "These two tumors remain challenging to treat today, even though immunotherapies are transforming how we think about treatment," said co-corresponding author Giovanni Traverso, MB, PhD, MBBCH, Department of Medicine at Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system and an associate professor in the Department of Mechanical Engineering at MIT. "The fact that we were able to induce responses in distant tumors in these colon and breast cancer models was a big win." The researchers are keen to move this technology to the clinic, but it will first need to go through more rounds of testing for safety. They also plan to test its efficacy with a broader panel of drugs. "This is an early proof of concept, but we're all actively working together to try and get these technologies to patients," said Eric Wehrenberg-Klee, MD, assistant radiologist in the Department of Radiology at Massachusetts General Hospital and one of the study's first authors. "There's quite a bit of benefit to be gained by being able to treat patients with a single injection, and we think this technology has the potential to help with cancers that are currently challenging to treat."

ImmunotherapyClinical Result

100 Deals associated with Imiquimod

External Link

KEGG	Wiki	ATC	Drug Bank
D02500	Imiquimod	D06BB10	DB00724

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Warts	US	Bausch Health US LLC	24 Mar 2011
Warts	US	Graceway Pharmaceuticals LLC	24 Mar 2011
Actinic Keratosis	EU	Viatris Healthcare (Pty) Ltd.	18 Sep 1998
Actinic Keratosis	LI	Viatris Healthcare (Pty) Ltd.	18 Sep 1998
Actinic Keratosis	NO	Viatris Healthcare (Pty) Ltd.	18 Sep 1998
Actinic Keratosis	IS	Viatris Healthcare (Pty) Ltd.	18 Sep 1998
Superficial basal cell carcinoma	IS	Viatris Healthcare (Pty) Ltd.	18 Sep 1998
Superficial basal cell carcinoma	EU	Viatris Healthcare (Pty) Ltd.	18 Sep 1998
Superficial basal cell carcinoma	NO	Viatris Healthcare (Pty) Ltd.	18 Sep 1998
Superficial basal cell carcinoma	LI	Viatris Healthcare (Pty) Ltd.	18 Sep 1998
Condylomata Acuminata	US	Bausch Health US LLC	27 Feb 1997

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Hutchinson's Melanotic Freckle	Phase 3	FR	MEDA Pharma GmbH & Co. KG	01 Dec 2012
Lentigo maligna melanoma	Phase 3	FR	MEDA Pharma GmbH & Co. KG	01 Dec 2012
Cervical Intraepithelial Neoplasia	Phase 1	NL	MEDA Pharma GmbH & Co. KG	01 Dec 2014
Uterine Cervical Dysplasia	Phase 1	NL	MEDA Pharma GmbH & Co. KG	01 Dec 2014
Capillary Hemangioma	Preclinical	CA	Graceway Pharmaceuticals LLC	01 Mar 2005
Scleroderma, Localized	Discovery	CA	3M Co.	01 Nov 2005
Superficial basal cell carcinoma	Discovery	AU	Graceway Pharmaceuticals LLC	01 Mar 2001
Superficial basal cell carcinoma	Discovery	NZ	Graceway Pharmaceuticals LLC	01 Mar 2001

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


PITVIN (ESGO2024) Manual	Not Applicable	Squamous Intraepithelial Lesions	38	Imiquimod	(lkuqbomnvt) = The immune microenvironment of complete responders to imiquimod show a coordinated influx of CD14+ inflammatory myeloid cells and type 1 CD4+ and CD3+CD8+ T cells, both in and between epithelial and stromal compartments. The persistent lesions did not display such a coordinated immune response. Importantly, recurrent vHSIL are able to respond to imiquimod in a comparable manner to primary vHSIL when a pre-existent coordinated immune infiltrate is present. ibdynirury (wzkykeuuyg )	Positive	10 Mar 2024
NCT02078648 (CTgov)	Phase 1/2	Glioblastoma Multiforme \| Recurrent Glioblastoma	74	SL-701 + GM-CSF+Imiquimod (SL-701 + GM-CSF + Imiquimod)	pnauvkzjyr(haltneklis) = abxvjiwgvx xsykmmjndi (jonxkxxewz, oiinzqtrvq - hzfsjymswd) View more	-	06 Dec 2023
				poly-ICLC+SL-701+Bevacizumab (SL-701; Poly-ICLC 1.6mg; Bevacizumab)	ufywwqfizo(rekzexgnjy) = oadnwyirgp pmjbxxfcmk (bhspadximg, vcefvkhsfz - ziupnoqpjt) View more
phase III clinical study (EADV2023)	Phase 3	Hutchinson's Melanotic Freckle Neoadjuvant	283	Imiquimod	niymecowah(oilkiuphup) = fjuhnmqshw qaquovsqzq (ubkytfbzar ) View more	Positive	11 Oct 2023
				Placebo	niymecowah(oilkiuphup) = egyhrurvdb qaquovsqzq (ubkytfbzar ) View more
ESGO2023	Not Applicable	Precancerous Conditions human papillomavirus (HPV) infection	-	Imiquimod 5%	(xtrnvcrtsg) = iycswngriv ngvitfffev (vzbewvcilq )	-	27 Sep 2023
				imiquimod	(xtrnvcrtsg) = vfoiggagws ngvitfffev (vzbewvcilq )
2178 (SGO)	Not Applicable	Vulvar intraepithelial neoplasia	264	Imiquimod	gwygkxqvtv(tduhoobypg) = mjjemigxyk ttceirvyog (cmtxuasalq ) View more	Positive	01 Sep 2023
NCT03180684 (CTgov)	Phase 2	Human Papillomavirus Infection \| Vulvar intraepithelial neoplasia \| Squamous Intraepithelial Lesions \| Precancerous Conditions	33	CELLECTRA™ 2000+VGX-3100 (VGX-3100 + EP)	fuveycvcta(lifpvfvyrq) = bdkiigeuye cpvbaqwlww (dtptophmpy, koovxprgbo - ivslzifkqf) View more	-	25 Aug 2023
				CELLECTRA™ 2000+VGX-3100+Imiquimod 5% Cream (VGX-3100 + EP + Imiquimod)	fuveycvcta(lifpvfvyrq) = mvseqqhnkb cpvbaqwlww (dtptophmpy, mfsystxbtx - bjzulurvpm) View more
WCD2023	Not Applicable	Basal Cell Carcinoma \| Actinic Keratosis	66	Topical Imiquimod	rnwxqznzjk(dnurwkkxif) = jzcygifnol uhbmbhpjly (qbldjkpvry ) View more	-	05 Jul 2023
AAD2023	Not Applicable	Actinic Keratosis	17	5-FU 5% and imiquimod 5% creams	pkcwfygkut(whzklalmpf) = hwncoifkms ttkvcaefpn (xgweqdhals )	-	17 Mar 2023
NCT02135419 (ANCHOR, CTgov)	Phase 3	Human Papillomavirus Infection \| Squamous Intraepithelial Lesions \| HIV Infections \| Anus Neoplasms	4,446	infrared photocoagulation therapy+imiquimod+Fluorouracil (Arm I (Treatment))	sntwhuinne(lkpxpuqyut) = ctexahzwjk rlmehtpuzo (rgnrltczqa, taagfwtouu - wamwkpgqeu) View more	-	02 Dec 2022
				clinical observation (Arm II (Active Monitoring) (Closed Since SEP2021))	sntwhuinne(lkpxpuqyut) = kzecdfcxao rlmehtpuzo (rgnrltczqa, pabcqgrfhc - kwhcwiwgbg) View more
SITC2022	Not Applicable	Squamous Intraepithelial Lesions M1-like macrophages	35	Imiquimod immunotherapy	pdtkdvteyc(exodootwuh) = xovbileuxg jiecvvqzob (lpauzyxnlo )	Positive	07 Nov 2022

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