Drug Type Small molecule drug |
Synonyms Obatoclax, Obatoclax mesylate (USAN) + [3] |
Target |
Action inhibitors |
Mechanism Bcl-2 inhibitors(Apoptosis regulator Bcl-2 inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
License Organization- |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
RegulationOrphan Drug (United States) |
Molecular FormulaC21H23N3O4S |
InChIKeyZFKXDVMHNXPEIY-UHFFFAOYSA-N |
CAS Registry803712-79-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D08954 | Obatoclax mesylate | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Extensive stage Small Cell Lung Cancer | Phase 3 | - | 01 Aug 2012 | |
Extensive stage Small Cell Lung Cancer | Phase 3 | - | 01 Aug 2012 | |
Myelodysplastic Syndromes | Phase 3 | United States | - | |
Myelodysplastic Syndromes | Phase 3 | United States | - | |
Small Cell Lung Cancer | Phase 3 | Poland | - | |
Small Cell Lung Cancer | Phase 3 | United States | - | |
Small Cell Lung Cancer | Phase 3 | India | - | |
Small Cell Lung Cancer | Phase 3 | Hungary | - | |
Small Cell Lung Cancer | Phase 3 | Bulgaria | - | |
Systemic Mastocytosis | Phase 3 | United States | - |
Not Applicable | - | lctdhdpvfb(mgzkpcqpok) = rhrxhlzevj fdetftwgyt (ejxcyqzlwd ) | Positive | 27 Apr 2025 | |||
Phase 1/2 | 11 | tnbkvqbcux(xrkmxyjewe) = fkfncpclpo pueficshku (sibfhgjwji, dvhgheined - dydycewfnh) View more | - | 09 Dec 2013 | |||
Phase 1 | 11 | (ezjfesshtb) = 4 DLTs were seen: at original dose level 1 grade 4 thrombocytopenia and delay of therapy > 15 days. At dose level 2, 1 patient had grade 3 somnolence, a 2nd patient grade 3 euphoria and grade 4 thrombocytopenia. No DLTs were seen at amended dose level 1 doqdgososy (otoxnstggk ) View more | - | 20 May 2012 | |||
Phase 2 | 22 | mcreupcslb(msuvyjhmvw) = 11% kvjxefreib (pgbyxlnyuu ) View more | Negative | 01 Dec 2011 | |||
Phase 2 | 3 | (lgdtsuoozf) = oamdrbnijh ehtfoxuumg (xnpbffgaef, oqrdzmjqmk - ihcxgiyafu) View more | - | 25 Apr 2011 |