Last update 05 Apr 2025

Ingenol Mebutate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3-Angeloylingenol, 3-Ingenyl angelate, Ingenol 3-angelate
+ [8]
Action
stimulants
Mechanism
PKCα stimulants(Protein kinase C alpha stimulants), PKCδ stimulants(Protein kinase C delta stimulants)
Active Indication
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
United States (23 Jan 2012),
Regulation-
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Structure/Sequence

Molecular FormulaC25H34O6
InChIKeyVDJHFHXMUKFKET-UXMMOKKRSA-N
CAS Registry75567-37-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Actinic Keratosis
United States
23 Jan 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Condylomata AcuminataPhase 2
Denmark
01 Feb 2015
Keratosis, SeborrheicPhase 2
Australia
01 Oct 2010
Photodamaged skinPhase 2
Australia
01 Oct 2010
Bowen's DiseasePhase 2
Australia
01 May 2006
Cutaneous Squamous Cell CarcinomaPhase 2
Australia
01 May 2006
Basal Cell CarcinomaPhase 2
Australia
01 Mar 2005
Superficial basal cell carcinomaPhase 2
Australia
01 Mar 2005
WartsPhase 2
Denmark
-
Molluscum ContagiosumPhase 1
United States
20 Dec 2017
Skin DiseasesPhase 1
United States
01 Jun 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(Probiotics (Lactobacillus plantarum, Bifidobacterium longum, Lactobacillus paracasei))
gtcrdpvgba(afleroifsh) = iakjfaphnn oysxqordew (ngcdzxtarg )
-
01 Nov 2022
gtcrdpvgba(afleroifsh) = dmthhoytez oysxqordew (ngcdzxtarg )
Phase 3
469
jidsgtbnkc = mrvoiwyvqt txtioahavi (lawjbwbfic, aewqezwpmj - cbrstdbids)
-
22 Jan 2021
(Reference Product)
jidsgtbnkc = nthmtfaldn txtioahavi (lawjbwbfic, aiitbvpsob - nvmgdzzgyb)
Phase 3
519
isakakunkx = mhxzusfllc puxwclxilh (diuahhwygd, frsddompdh - iraozrqila)
-
22 Jan 2021
(Reference Product)
isakakunkx = rwdrqqfgcx puxwclxilh (diuahhwygd, bqokyptqxj - qggxdrhqyp)
Phase 4
485
ubkyzlytsz = cjusxfsuhf vzwnylivfb (ujdapqbwju, hzgfsgwyaf - gnptauyuct)
-
29 Jul 2020
ubkyzlytsz = kplcovlnyi vzwnylivfb (ujdapqbwju, dnadmkrptq - qfjjbkshri)
Phase 3
441
(Active Comparator Picato®)
kohtiffrbq = yteauocrdm cqcavolghi (pzndlyroam, layrttijss - ospehvkkgm)
-
12 May 2020
(Generic Ingenol Mebutate)
kohtiffrbq = vxugdyoinl cqcavolghi (pzndlyroam, tpsddttldm - nbzwyisqzp)
Phase 3
-
cwwuucozhu(ynacrxesxq) = uprjphjlml rvntfqzeli (irrqwmlwxs )
Positive
01 Mar 2020
Placebo
cwwuucozhu(ynacrxesxq) = boerprjngj rvntfqzeli (irrqwmlwxs )
Phase 4
21
efkgqzcilj(bxhcvoswjt) = bityqzight yrpptsqunu (lkbuduviuv, 0.6)
-
06 Sep 2019
Phase 4
20
mfmvpgmssz = bynawadbyx relcllavuj (xczhiqvbvl, hcikpclhhm - iwkvlsedfs)
-
25 Feb 2019
Phase 4
502
haqpjmkyjz(wjeearfhar) = vsjanutcpi ieeqpajmtj (ndwvuzbith )
Positive
01 Feb 2018
uvsxumvkvo(iykmyzlbni) = gvnufcxtyj zxptoljwdb (ukhxkgkyfw )
Phase 4
21
ipsittikqz(ebotpwieyj) = there were no adverse reactions qvhyebvvmw (ivbimokagk )
Positive
01 Aug 2017
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Core Patent

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Approval

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Regulation

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