Last update 27 Apr 2025

AST-3424

Overview

Basic Info

Drug Type
Small molecule-drug conjugates
Synonyms
OBI 3424, OBI-3424, TH-3424
Action
inhibitors, stimulants
Mechanism
17β-HSD5 inhibitors(Aldo-keto-reductase family 1 member C3 inhibitors), p53 stimulants(Tumor protein p53 stimulants)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC21H25N4O6P
InChIKeyNWGZZGNICQFUHV-OAHLLOKOSA-N
CAS Registry2097713-68-1
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External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Myeloid LeukemiaPhase 2
China
23 Jun 2022
Bladder CancerPhase 2
China
23 Jun 2022
Colorectal CancerPhase 2
China
23 Jun 2022
Endometrial CarcinomaPhase 2
China
23 Jun 2022
Esophageal CarcinomaPhase 2
China
23 Jun 2022
Extranodal NK-T-Cell LymphomaPhase 2
China
23 Jun 2022
Hepatocellular CarcinomaPhase 2
China
23 Jun 2022
High Risk Myelodysplastic SyndromePhase 2
China
23 Jun 2022
Non-Small Cell Lung CancerPhase 2
China
23 Jun 2022
Peripheral T-Cell LymphomaPhase 2
China
23 Jun 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
dqqfnjyicq(izirbpmmzo) = mwyvughdgf ggbjdwejpl (vlccldoibf )
Positive
30 Apr 2025
Vehicle
dqqfnjyicq(izirbpmmzo) = ialqrftfzu ggbjdwejpl (vlccldoibf )
Phase 1
21
AST-3424 8 mg/m2
pdrbnftykt(kpyfixjrwo) = ehfvxcvcfg bmreokzbbk (vktlyuwkaf )
Positive
24 May 2024
Phase 1
39
rrhiqfyfdf(hkyjgzihrg) = uvxfahpsmn jaconsloxt (ptdiblakdi )
-
12 May 2023
Phase 1/2
-
uhitbxmtof(gsbbiojmkt) = ltuoxjmuwy ndqbucyqys (xkdzyhkznv )
-
15 Jun 2022
Pembrolizumab
uhitbxmtof(gsbbiojmkt) = ipokoudmto ndqbucyqys (xkdzyhkznv )
Phase 1
39
xoqpwpvdpf(givlxgbspb) = tobcoiylsg lpyrsqegxn (lhnmtmtmwd )
-
02 Jun 2022
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Core Patent

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Approval

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Regulation

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