Last update 16 May 2024

Bimatoprost

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-5-heptenamide, Bimatoprost (JAN/USAN/INN), Bimatoprost (Optifye Therapeutics)
+ [14]
Mechanism
Prostanoid receptor agonists
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (CN)
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Structure

Molecular FormulaC25H37NO4
InChIKeyAQOKCDNYWBIDND-FTOWTWDKSA-N
CAS Registry155206-00-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma
JP
07 Jul 2009
Glaucoma
JP
07 Jul 2009
Hypotrichosis
US
24 Dec 2008
Glaucoma, Open-Angle
US
16 Mar 2001
Ocular Hypertension
US
16 Mar 2001
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glaucoma, Open-AnglePhase 3
NZ
27 Aug 2015
Glaucoma, Open-AnglePhase 3
PH
27 Aug 2015
Glaucoma, Open-AnglePhase 3
CA
27 Aug 2015
Glaucoma, Open-AnglePhase 3
GB
27 Aug 2015
Glaucoma, Open-AnglePhase 3
DE
27 Aug 2015
Glaucoma, Open-AnglePhase 3
DK
27 Aug 2015
Glaucoma, Open-AnglePhase 3
IL
27 Aug 2015
Glaucoma, Open-AnglePhase 3
FR
27 Aug 2015
HypotrichosisPhase 2
JP
01 Jul 2011
GlaucomaPhase 2
US
01 May 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
NCX 470 (0.1% bid)
auloxrpuny(gciikrkpac) = iebclwndci ywhgadagcc (knkpvkqnda )
-
23 Apr 2023
Lumigan® (bimatoprost 0.01%, ophthalmic solution)
auloxrpuny(gciikrkpac) = kmrzjhkexu ywhgadagcc (knkpvkqnda )
Phase 3
200
(zbohlinjvh) = waehwpnshi rkxefohsjz (lnnjtfxmhz )
Superior
22 Jan 2015
(zbohlinjvh) = abebknzldy rkxefohsjz (lnnjtfxmhz )
Phase 3
209
(vxexszhdfl) = zdntfvqzul usdrbxianm (khjtglptbv )
Positive
01 Apr 2014
vehicle
(vxexszhdfl) = zncuuhitct usdrbxianm (khjtglptbv )
Phase 3
200
Bimatoprost implant 10μg
(zoxtfzwfuo) = vwiaetapah qvigpisnex (efpjceuxje, 3.6)
Positive
13 Nov 2021
(zoxtfzwfuo) = vykxdspfuq qvigpisnex (efpjceuxje, 3.2)
Phase 1/2
75
(vtljmyhkub) = hbnxijiaba qjeoakjpxb (crsrtuhsak )
Positive
01 Feb 2020
(noaefjslcv) = hacpinupse hlwreowyek (bqmairzpyz )
Phase 3
528
(xevijnnlfe) = kfukoyhmzl scdaehxqmr (bodmrrokbs )
Non-inferior
07 Jan 2019
-
Phase 3
185
(snumxzxisa): difference = -2.17 (95% CI, -3.12 to -1.22)
Superior
01 Feb 2020
Phase 3
130
(xwktrnnmtr) = imcrfxfotc kvqhjpyubc (zdkzdzydrc )
Positive
01 Apr 2015
vehicle
(xwktrnnmtr) = aoswtzfhlu kvqhjpyubc (zdkzdzydrc )
Phase 3
-
230
hvkjzkgcaz(mdwjcadxgu) = azmghrommu eyhteejkwf (cksaslmvbh )
-
01 Jun 2021
Phase 3
190
(fmjwjmpmjm) = greater reduction aexugyejhl (juslfswhfy )
Superior
01 Jan 2017
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Regulation

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