Last update 17 May 2025

Uplarafenib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
HLX 208, HLX-208, HLX208
+ [1]
Target
Action
inhibitors
Mechanism
BRAF inhibitors(Serine/threonine-protein kinase B-raf inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationBreakthrough Therapy (China)
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Structure/Sequence

Molecular FormulaC22H21F3N4O4S
InChIKeyHAYBWDINAFTFCJ-UHFFFAOYSA-N
CAS Registry1425485-87-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Solid tumorPhase 3
China
30 Jan 2023
Locally Advanced MelanomaPhase 2
China
21 Mar 2022
BRAF V600E mutant Colorectal CancerPhase 2
China
11 Mar 2022
BRAF V600 mutation-positive MelanomaPhase 2
China
14 Jan 2022
Glioblastoma Harboring BRAF V600 MutationPhase 2
China
14 Jan 2022
Advanced Malignant Solid NeoplasmPhase 2
China
28 Dec 2021
BRAF-mutation brain cancerPhase 2
China
15 Dec 2021
Advanced Thyroid Gland CarcinomaPhase 2
China
10 Dec 2021
Anaplastic Thyroid CarcinomaPhase 2
China
10 Dec 2021
Ataxia TelangiectasiaPhase 2
China
10 Dec 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
30
behprpzlyq(surstfivpj) = cahvsequrg imcyjkoruv (piqzmbzrgh, 75.1 - 99.9)
Positive
03 Dec 2023
Phase 2
22
ewkelisevz(kiopdwrhjq) = aecvaqpypp vhdhodlxgf (bjwcldtnof, 55.5 - 99.7)
Positive
31 May 2023
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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