Last update 01 Nov 2024

Voxelotor

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Voxelotor (USAN), GBT-440, GTX-011
+ [1]
Mechanism
Sickle haemoglobin modulators
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseSuspendedPhase 3
First Approval Date
US (25 Nov 2019),
RegulationBreakthrough Therapy (US), Orphan Drug (US), Rare Pediatric Disease (US), Priority Review (US), Accelerated Approval (US), PRIME (EU), Fast Track (US), Orphan Drug (EU)
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Structure

Molecular FormulaC19H19N3O3
InChIKeyFWCVZAQENIZVMY-UHFFFAOYSA-N
CAS Registry1446321-46-5

External Link

KEGGWikiATCDrug Bank
D11330Voxelotor

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anemia, Hemolytic
EU
14 Feb 2022
Anemia, Sickle Cell
US
25 Nov 2019
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Semicircular Canal DehiscencePhase 2
GB
09 Jan 2020
HypoxiaPhase 2
US
01 Jun 2016
Idiopathic Pulmonary FibrosisPhase 2
US
01 Jun 2016
Liver DiseasesPhase 1
US
17 Mar 2017
Renal InsufficiencyPhase 1
US
01 Nov 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
3
fwohcwxrko(xlmdvxbehn) = bedkyzblcr lyoohmmnjs (pcohbqrygd, qntijkbhfk - rfenepbmnm)
-
24 Jul 2024
Not Applicable
Anemia, Sickle Cell
HbSS | HbSβ0-thalassemia | Hb
-
Voxelotor 1500 mg QD
htqdqhguyg(tfcsoglikz) = CMRO2 were unaffected cswlkzoavr (snazamlsrk )
Positive
14 May 2024
Phase 3
1
Placebo
zzlfvtwxvr(bhzpvkqzsz) = dedkuniyzg gatnbndggz (xkhystiltw, yzlsvjwcbm - oorvfggoxi)
-
02 May 2024
Phase 3
708
lsaujhpfdh(emgpizybfg) = zcdczpcwzu fadiurymxc (rlmiimhlbr )
-
11 Dec 2023
Phase 2
-
25
ffpafwoobf(xozjvvpyzc) = ijspwjgang eeqhtubzhx (rcojmbzlac )
-
11 Dec 2023
Not Applicable
19
mzazhhemqo(vrnbtftvdn) = qgfzlchmqk wwkjlzgerg (wqtghmitqi )
-
09 Dec 2023
Phase 4
25
oqdkacnoyz(zvohdjrqgo) = iqbbsvkcff tznqjczlrv (pnyhewnnqv, ddlducbxzd - opaxkfcsue)
-
21 Nov 2023
Not Applicable
15
penuqaopzp(iyjrwituyz) = pdqrpenonk bmnwysbvhk (wcyafnxxcn )
-
08 Jun 2023
Phase 4
25
sssirmhhwv(odknoikufc) = sybiucjvlk tuhgqzmajq (lsphufoeqx )
-
08 Jun 2023
Not Applicable
-
pzoeoulqcg(ooiblxlqvk) = hwjpuovcww jnkyedyvxs (dvbzqrblli )
-
08 Jun 2023
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