Last update 29 Nov 2024

Bentracimab

Overview

Basic Info

Drug Type
Fab fragment
Synonyms
MEDI-2452, PB 2452, PB-2452
+ [1]
Mechanism
ticagrelor inhibitors
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationPriority Review (US), Breakthrough Therapy (US)
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External Link

KEGGWikiATCDrug Bank
-Bentracimab--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HemorrhageNDA/BLA
US
02 Aug 2024
Massive hemorrhagePhase 3
BE
06 Jul 2020
Massive hemorrhagePhase 3
BE
06 Jul 2020
Massive hemorrhagePhase 3
CA
06 Jul 2020
Massive hemorrhagePhase 3
CA
06 Jul 2020
Massive hemorrhagePhase 3
IT
06 Jul 2020
Massive hemorrhagePhase 3
IT
06 Jul 2020
Massive hemorrhagePhase 3
SE
06 Jul 2020
Massive hemorrhagePhase 3
SE
06 Jul 2020
Massive hemorrhagePhase 3
CH
06 Jul 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
207
(Bentracimab (PB2452))
fblpuqctly(ybtehkjmny) = ikrzwylyml xqvpqohnif (ilornbozai, sawlffzeao - lqvcaltesq)
-
08 Apr 2024
Placebo (0.9% Sodium chloride) infusion+Ticagrelor Oral Tablet - Pre-Treatment+Aspirin (ASA) Oral Tablet - Pre-Treatment
(Placebo)
fblpuqctly(ybtehkjmny) = oahlcswcgs xqvpqohnif (ilornbozai, gopnwdhxjm - nypsoktixc)
Phase 2
205
Ticagrelor+Aspirin+Bentracimab
rncdhjfazg(jxhrpbxjff) = significantly restored tllugqkorb (rjbllwethz )
Positive
04 Apr 2022
Ticagrelor+Aspirin+Placebo
Phase 3
platelet function
150
ldoetuhzqx(slavxugnez) = wrlcjprwxh iucztmjogg (aqtwzbcpli )
Positive
22 Feb 2022
Phase 2
-
zrlsjsbohm(soytxbkitp) = To date, PB2452 has been generally well tolerated in the Phase 2a trial, with only minor adverse events reported. ccbczddnau (amhximdzai )
Positive
17 Jun 2019
Phase 1
-
64
vhaqtixzpj(wppjofpfue) = limited mainly to issues involving the infusion site ljiueyvgea (euqstzakvc )
Positive
09 May 2019
Placebo
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Regulation

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