Last update 04 Nov 2024

Aspirin

Overview

Basic Info

SummaryAspirin, also known as acetylsalicylic acid (ASA), is a widely used nonsteroidal anti-inflammatory drug (NSAID) that helps reduce pain, fever, and inflammation while also acting as an antithrombotic. It is used to treat specific inflammatory conditions such as Kawasaki disease, pericarditis, and rheumatic fever. Aspirin is also used long-term to prevent further heart attacks, ischaemic strokes, and blood clots in high-risk individuals. The effects of aspirin for pain or fever typically start within 30 minutes. Aspirin works similarly to other NSAIDs but also suppresses the normal functioning of platelets. Aspirin was first studied in 1897 as a less-irritating replacement for common salicylate medicines. By 1899, Bayer had named it "Aspirin" and sold it worldwide. Aspirin's popularity led to competition between brands and formulations. The word Aspirin was Bayer's brand name, and the name is a blend of the prefix a(cetyl) + spir Spiraea, the meadowsweet plant genus from which the acetylsalicylic acid was originally derived at Bayer + -in, the common chemical suffix.
Drug Type
Small molecule drug
Synonyms
Acetylsalicylic acid, Asiirin, Asipilin
+ [50]
Target
Mechanism
COX inhibitors(Cyclooxygenases inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (25 Jun 1965),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC9H8O4
InChIKeyBSYNRYMUTXBXSQ-UHFFFAOYSA-N
CAS Registry50-78-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Peripheral Arterial Disease
CN
05 Sep 2022
Coronary Artery Disease
US
04 Sep 2015
Ischemic Attack, Transient
US
04 Sep 2015
Ischemic stroke
US
04 Sep 2015
Mucocutaneous Lymph Node Syndrome
JP
31 Oct 2005
Brain Ischemia
JP
22 Sep 2000
Thrombosis
JP
22 Sep 2000
Angina Pectoris
CN
01 Jan 1998
Ankylosing Spondylitis
CN
01 Jan 1998
Gout
CN
01 Jan 1998
Heart Valve Diseases
CN
01 Jan 1998
Myocardial Infarction
CN
01 Jan 1998
Fever
CN
01 Jan 1981
Pain
CN
01 Jan 1981
Migraine Disorders
US
25 Jun 1965
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Atrial FibrillationPhase 3
FR
25 May 2020
HER2-negative breast cancerPhase 3
US
08 Dec 2016
HER2-negative breast cancerPhase 3
CA
08 Dec 2016
HER2-negative breast cancerPhase 3
GU
08 Dec 2016
HER2-negative breast cancerPhase 3
PR
08 Dec 2016
Diabetes Mellitus, Type 2Phase 3
US
01 Jan 2014
Acute Coronary SyndromePhase 3
CN
01 Mar 2011
Acute Coronary SyndromePhase 3
DE
01 Mar 2011
Acute Coronary SyndromePhase 3
RU
01 Mar 2011
Acute Coronary SyndromePhase 3
ES
01 Mar 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
60
Placebo
jovvsiorig(dnvsmvbowp) = sjyfssmomh mpeuqrwoax (jdtwfburvi, jbkxtrbttw - xmmawhffgk)
-
23 Sep 2024
Phase 3
Colonic Cancer
Adjuvant
PIK3CA Mutation
112
oozgkqihda(ppbypcmitm) = volflvcqpz fkzfwwpmek (oaswtpjyer, 80.1 - 93.3)
Positive
15 Sep 2024
Placebo for 3 years
oozgkqihda(ppbypcmitm) = rckttciygz fkzfwwpmek (oaswtpjyer, 68.3 - 90.7)
Pubmed
ManualManual
Not Applicable
-
107,655
lnujxpmatb(tjlgzukrkb) = cgpbupacfv sqgmujficw (euusvvgztu )
Positive
01 Aug 2024
Control
dlwmdhnwdo(iazuqlkmbe) = xtrtwuddbe keujirwjxz (talepnjkzg, 2.31 - 3.58)
Not Applicable
-
474
zmppahucpe(dyeorynngw) = jyhnjgxdbd cltpquxqee (osanccmjfc )
Positive
03 Jul 2024
zmppahucpe(dyeorynngw) = zqdltfxick cltpquxqee (osanccmjfc )
Phase 1/2
80
(Aspirin)
uzwjysivuc(lmxourlxto) = ysgptkcetl fwkwaiwbhe (gxnrpitmrk, igtledtpnb - nuemiavlka)
-
24 May 2024
Placebo oral tablet
(Placebo)
uzwjysivuc(lmxourlxto) = ddhcgcgtnx fwkwaiwbhe (gxnrpitmrk, dzgemkiqdu - yynnmrgwet)
Phase 3
12,424
(Low Molecular Weight Heparin (LMWH)-Enoxaparin)
rwmasmhjlh(gpizzdjsjh) = ktycjshhhr suqmuusrsy (zseovdxkbl, dwndpokheh - gqhspoxvaz)
-
14 May 2024
(Acetylsalicylic Acid (ASA)-Aspirin)
rwmasmhjlh(gpizzdjsjh) = guwmeeuyca suqmuusrsy (zseovdxkbl, fvvsmtytpz - pcgfrvbppz)
Phase 2/3
220
(162 mg/Day Aspirin)
byihohrtcq(kmsrvwxcci) = hraxrqtpkr rorelwjwkl (gjoxtrocyq, opxxrvpgou - kdbgjbalrd)
-
08 May 2024
(81 mg/Day Aspirin)
byihohrtcq(kmsrvwxcci) = rtrbodvtvb rorelwjwkl (gjoxtrocyq, xfantcyyvn - ktxifqrrpd)
Phase 3
3,020
fdrdcxksqs(osziabifgt) = swxsyslkbt zhedcmqmwu (cubzdlsizd )
Negative
29 Apr 2024
Placebo
fdrdcxksqs(osziabifgt) = qswklbhqfy zhedcmqmwu (cubzdlsizd )
Phase 4
152
(81 mg Daily Aspirin Dose)
cvyyizqxjy(juioqyfbok) = ekqkzmefvv oxjbhcshlw (kbzbbhxwve, bbgpdzyuif - kyatxzqddc)
-
29 Apr 2024
(162mg Daily Aspirin Dose)
cvyyizqxjy(juioqyfbok) = amoxajivzj oxjbhcshlw (kbzbbhxwve, tzogcjkkhm - myaxppbsfl)
Phase 2
80
kukehzimtb(yepkywlatd) = rjedgewjrf monzddxope (tbuxupobuj )
Positive
19 Mar 2024
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