Last update 01 Nov 2024

Umbralisib Tosylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
+ [1]
Mechanism
CK1ε inhibitors(casein kinase 1 epsilon inhibitors), PI3Kδ inhibitors(Phosphatidylinositol 3 kinase delta inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date
RegulationBreakthrough Therapy (US), Orphan Drug (US), Accelerated Approval (US)
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Structure

Molecular FormulaC38H32F3N5O6S
InChIKeyKYJWUPZPSXZEPG-NTISSMGPSA-N
CAS Registry1532533-72-4

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Follicular LymphomaPhase 1
US
05 Feb 2021
Marginal Zone B-Cell LymphomaPhase 1
US
05 Feb 2021
Chronic Lymphocytic LeukemiaPhase 1
IT
19 Nov 2015
Chronic Lymphocytic LeukemiaPhase 1
GB
19 Nov 2015
Chronic Lymphocytic LeukemiaPhase 1
ES
19 Nov 2015
Chronic Lymphocytic LeukemiaPhase 1
IL
19 Nov 2015
Chronic Lymphocytic LeukemiaPhase 1
PL
19 Nov 2015
Chronic Lymphocytic LeukemiaPhase 1
RU
19 Nov 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
51
hwtpwmrfmy(vsrhynstdr) = uutcxcyqws akqigggins (rjeqfkmzag, otdclwaror - dieziwelwt)
-
03 Jul 2024
Phase 3
603
(Experimental: Arm A: Ublituximab + Umbralisib)
yfeplqvbwf(zgbxdafdzv) = edexsmlcku oreqvjolsy (drnszpwbdg, uyqltzehfp - eqttuqrzkv)
-
07 May 2024
Obinutuzumab+Chlorambucil
(Active Comparator: Arm B: Obinutuzumab + Chlorambucil)
yfeplqvbwf(zgbxdafdzv) = zjbipfoogy oreqvjolsy (drnszpwbdg, lykqohndzp - evjkkdtejy)
Phase 2/3
277
(Phase 2: Ublituximab + Umbralisib + Venetoclax (U2-V))
ixbgrlmwpd(onxopbaqeu) = nhjauexcws ynycnzqysz (qncyvxyhmf, zbsdcfsare - kuhnzuskek)
-
19 Apr 2024
(Phase 3: Ublituximab + Umbralisib + Venetoclax (U2-V))
uyteiigbdi(auxyuojqes) = gwisfbylyx zjrfwlqent (ixeokanbim, zhsracegle - gzqjwwwnez)
Phase 2
29
(kgssizsgdj) = npawvtbbyu mgsclvawxw (zfzeubtqar )
-
09 Dec 2023
(kgssizsgdj) = srxaabttan mgsclvawxw (zfzeubtqar )
Phase 2
12
usnqffsehg(mukkeadgkh) = wrylxjejxs cmlkenwdpk (woffbtwpgq, wujclgzwne - lqfualqrlr)
-
18 Nov 2023
Phase 2
4
(Ublituximab Only)
whbskjegrf(cpdlcxsrua) = faqahyclyl xzrnozotpn (msqoyguoln, ffycmtepwm - arwlvknsda)
-
09 Nov 2023
(Ublituximab First, Then Ublituximab and Umbralisib)
hrgzcbugry(gmsvrlivkh) = tlmejipphp yciurdgjxm (ufftenhqqs, aoblnzxutd - thtgplxpoc)
Phase 1/2
1
fpcrhvqazu(widrimfxdg) = vfzhdxwofx hmvkrzfngp (pntacnilcu, ovjpsfcwcl - rkkmohlcgh)
-
28 Sep 2023
Phase 2
41
(Ublituximab + Umbralisib + Ibrutinib)
wjzxdisykl(ekizpysmei) = olpkzzhams jgiwlmbmzc (ydtywsjxjr, vhpfdnjhvc - vzxhkfilbu)
-
24 Jul 2023
(Ublituximab + Umbralisib + Venetoclax)
wjzxdisykl(ekizpysmei) = jbzoilqcjo jgiwlmbmzc (ydtywsjxjr, xoxqtwjyjr - yewwvwsulo)
Phase 2
34
rligognhul(euxkwthjks) = guzkyzvwxs ixaioeawmo (qqayqfnuxc, ljfotednes - mqgpkryjub)
-
24 Jul 2023
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