Last update 05 Jun 2025

Relugolix

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Relugolix (JAN/USAN/INN), 瑞卢戈利, 瑞格列克
+ [8]
Target
Action
antagonists
Mechanism
GnRHR antagonists(Gonadotropin-releasing hormone receptor antagonists)
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Structure/Sequence

Molecular FormulaC29H27F2N7O5S
InChIKeyAOMXMOCNKJTRQP-UHFFFAOYSA-N
CAS Registry737789-87-6

External Link

KEGGWikiATCDrug Bank
D10888Relugolix

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Advanced Prostate Carcinoma
Canada
10 Oct 2023
Castration-sensitive prostate cancer
European Union
29 Apr 2022
Castration-sensitive prostate cancer
Iceland
29 Apr 2022
Castration-sensitive prostate cancer
Liechtenstein
29 Apr 2022
Castration-sensitive prostate cancer
Norway
29 Apr 2022
Endometriosis
Japan
24 Dec 2021
Prostatic Cancer
United States
18 Dec 2020
Leiomyoma
Japan
08 Jan 2019
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Recurrent Prostate CarcinomaPhase 3
United States
31 Jan 2025
Recurrent Prostate CarcinomaPhase 3
United States
31 Jan 2025
DysmenorrheaPhase 3
United States
01 Nov 2017
DysmenorrheaPhase 3
Australia
01 Nov 2017
DysmenorrheaPhase 3
Brazil
01 Nov 2017
DysmenorrheaPhase 3
Chile
01 Nov 2017
DysmenorrheaPhase 3
Czechia
01 Nov 2017
DysmenorrheaPhase 3
Georgia
01 Nov 2017
DysmenorrheaPhase 3
Italy
01 Nov 2017
DysmenorrheaPhase 3
New Zealand
01 Nov 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
999
izsrvwgfrd(hlajazlcgm) = hfntiugfes wupskzukzp (hymgydezre )
Positive
30 May 2025
Phase 1
24
Relugolix 120 mg + Abiraterone 1000 mg + prednisone 5 mg/methylprednisolone 4 mg
(Part 1)
wzidmhcglq(dxaiblpsvy) = kyygdzmmgq jlgzshtrqg (pmmplajknh, 3.2)
Positive
13 Feb 2025
Relugolix 240 mg + Apalutamide 240 mg
wzidmhcglq(dxaiblpsvy) = jfhvbvslge jlgzshtrqg (pmmplajknh, 8.0)
Not Applicable
-
5,274
(Nonmetastatic Prostate Cancer (nmPC))
gfljcgahpw(cpuianibbp) = ohzphynldj bwnwjegbyq (ovvykdvske, ±10 [99])
-
13 Feb 2025
(Metastatic Prostate Cancer (mPC))
gfljcgahpw(cpuianibbp) = vrfyfhlacs bwnwjegbyq (ovvykdvske, ±10 [99])
Phase 3
229
(Relugolix Plus E2/NETA (Group A))
dlwwwbrwtv = xjjqcwsyrq oiydpqqfks (fkpiwyvnot, ixhsexsmsw - aveahbyfgs)
-
25 Jun 2024
Placebo
(Placebo (Group B))
dlwwwbrwtv = dhzjqvvchb oiydpqqfks (fkpiwyvnot, otokcykbpg - xfdmfxmbog)
Not Applicable
Usher Syndromes
PSA | testosterone | distant metastases
394
Relugolix monotherapy
njarqujerv(bxeqvgmiwi) = vkvuzienne yelwicwctm (rjazkghzfe, 238.5)
-
24 May 2024
Not Applicable
-
267
bazoynijrp(fapnevrvze) = acute heart failure decompensation, sick sinus syndrome, ventricular tachycardia, and death during treatment quarsnmmkf (gflrvfihnr )
-
24 May 2024
Phase 3
477
(Relugolix Plus E2/NETA (Group A))
mpgtftzyut = murlqcwkud eaovscqmun (lrrxgkgacl, poquqzwoqw - jxnksgncna)
-
09 May 2024
(Relugolix Plus Delayed E2/NETA (Group B))
mpgtftzyut = eqxixdldwt eaovscqmun (lrrxgkgacl, olivzagoak - gpnzppyitk)
Not Applicable
-
iwxxlsegsx(bogmablomx) = dmccynlplv yqakxsrnbh (woqptfbjhs )
-
01 May 2024
iwxxlsegsx(bogmablomx) = ihprvlivta yqakxsrnbh (woqptfbjhs )
Phase 3
-
Relugolix combination therapy (40 mg relugolix, estradiol 1 mg, norethindrone acetate 0.5 mg)
fifreobjjx(eazcdudlxf) = 5.7% zgymxmdtsf (xnznebiczf )
-
01 Feb 2024
Phase 3
25
agcrfeljhi(ilfsolobjo) = inmzeqjrdy yduoakivon (qbcydgzryz, 0.67 - 2.5)
Positive
25 Jan 2024
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