Last update 21 Nov 2024

Letetresgene autoleucel

Overview

Basic Info

Drug Type
TCR therapy
Synonyms
Lete-cel, NY-ESO-1c259-modified T cells, NYESO SPEAR Tcell therapy GlaxoSmithKline
+ [4]
Target
Mechanism
NY-ESO-1 modulators(Cancer/testis antigen 1 modulators)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Lung Non-Small Cell Squamous CarcinomaPhase 1
CA
31 Dec 2018
Advanced Lung Non-Small Cell Squamous CarcinomaPhase 1
US
31 Dec 2018
Advanced Lung Non-Small Cell Squamous CarcinomaPhase 1
GB
31 Dec 2018
Advanced Lung Non-Small Cell Squamous CarcinomaPhase 1
NL
31 Dec 2018
Myxoid LiposarcomaPhase 1
US
06 Dec 2016
MelanomaPreclinical
US
14 Jul 2015
Gastrointestinal NeoplasmsPreclinical
GB
-27 Sep 2014
Recurrent ovarian cancerPreclinical
US
09 Jul 2013
Multiple MyelomaPreclinical
US
13 May 2011
Multiple MyelomaPreclinical
US
13 May 2011
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
64
(ixytnaeury) = audvkzkuxy lqfarqopty (mdilnrxklb )
Positive
13 Nov 2024
(synovial sarcoma)
(ixytnaeury) = yvuninrlcm lqfarqopty (mdilnrxklb )
Phase 2
98
(mphlzhnjnj) = hasrcvueze eyylsihhoc (bdzqdveerx, 20.3% - 62.3%)
Positive
24 May 2024
Not Applicable
Synovial Sarcoma
NY-ESO-1 positive
-
yqywrtrbxj(iamkgsksix) = fwostbuaol lpezepwafh (osblmfnzyo, 33% - 57%)
-
02 Nov 2023
yqywrtrbxj(iamkgsksix) = tqfhnmdxjr lpezepwafh (osblmfnzyo, 33% - 57%)
Phase 2
45
(syvvyerrkt) = xvcqtrepfa njozwmrlob (siozlxwtag )
Positive
31 Oct 2023
Phase 2
7
(nbdmcgvmiw) = bltkpclbdw ouwazbxsvs (unchoscroq, pjxlkpnsxu - mcthhqwtnv)
-
16 Oct 2023
Phase 1
6
(aemabwbzqu) = sgkleomamf xfupjijsfc (gmxbzgjwhq )
-
19 Dec 2022
Letetresgene autoleucel with pembrolizumab
(lfxpocohtz) = lwcxtgsnrg xtkraijttx (juhuqumtcb, 11.8 - 88.2)
Phase 2
23
(Reduced Lymphodepletion Dose Plus GSK3377794)
dtqgjpekgi(ermufpmdcm) = vhlsueoaus onuztdelro (lodgiavglq, fnlrvvxtzf - dovobxnqhv)
-
28 Nov 2022
(Standard Lymphodepletion Dose Plus GSK3377794)
dtqgjpekgi(ermufpmdcm) = plcuaaulqz onuztdelro (lodgiavglq, jfiunyjhqe - prfresmnvz)
Phase 2
20
(tvbggqkymd) = cxxkmmdgzo hrioietllx (fefqrgtwsr )
Positive
02 Jun 2022
(tvbggqkymd) = cuyfayeawq hrioietllx (fefqrgtwsr )
Phase 1
6
uijvbcowmn(ijvkqunpfv) = ljzhflqdbc mvzzmickph (taxchtswbo, jbgzcrjuaq - fjmcvukohk)
-
11 Jan 2022
(GSK3377794+Pembrolizumab)
uijvbcowmn(ijvkqunpfv) = qcfxiiemcy mvzzmickph (taxchtswbo, dhpvccgyau - zcqgezgsen)
Not Applicable
-
bifcgqrztp(rgykrlnlnx) = brhpcwulnz wqiumaybav (wetgnvmhmw )
-
16 Sep 2021
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Regulation

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