Last update 23 May 2025

Letetresgene autoleucel

Overview

Basic Info

Drug Type
TCR-T Cell therapy
Synonyms
Lete-cel, NY-ESO-1c259-modified T cells, NYESO SPEAR Tcell therapy GlaxoSmithKline
+ [4]
Target
Action
modulators
Mechanism
NY-ESO-1 modulators(Cancer/testis antigen 1 modulators)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 2/3
First Approval Date-
RegulationBreakthrough Therapy (United States)
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Structure/Sequence

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Myxoid LiposarcomaPhase 3
United Kingdom
-
Synovial SarcomaPhase 3
United Kingdom
-
LAGE-1a Positive Solid TumorsPhase 2
United States
31 Dec 2019
LAGE-1a Positive Solid TumorsPhase 2
Canada
31 Dec 2019
LAGE-1a Positive Solid TumorsPhase 2
France
31 Dec 2019
LAGE-1a Positive Solid TumorsPhase 2
Italy
31 Dec 2019
LAGE-1a Positive Solid TumorsPhase 2
Netherlands
31 Dec 2019
LAGE-1a Positive Solid TumorsPhase 2
Spain
31 Dec 2019
LAGE-1a Positive Solid TumorsPhase 2
United Kingdom
31 Dec 2019
NY-ESO-1 Positive Solid TumorsPhase 2
United States
31 Dec 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Myxoid Liposarcoma
NY-ESO-1-positive | HLA-A*02:05 | HLA-A*02:06-positive
23
(Cohort 1 (Reduced-dose lymphodepletion regimen))
bgnqopbzzl(ydzdlijlgh) = wvqspwdyuk mkfosclspm (tuodtnopoi, 2.5 - 55.6)
Positive
20 May 2025
(Cohort 2 (Standard-dose lymphodepletion regimen))
bgnqopbzzl(ydzdlijlgh) = ofdjfeydjj mkfosclspm (tuodtnopoi, 12.2 - 73.8)
Phase 2
64
smcjwcplpa(mmthdyaomp) = lsheszohfc dqfcqqogjd (wilrgeacwq )
Positive
13 Nov 2024
(synovial sarcoma)
smcjwcplpa(mmthdyaomp) = uvictfgrtu dqfcqqogjd (wilrgeacwq )
Phase 2
98
dqffxzqnxu(taczaanmut) = rhtkrzdhxl ucihqcsaby (clodkddtmi, 20.3% - 62.3%)
Positive
24 May 2024
Not Applicable
Synovial Sarcoma
NY-ESO-1 positive
-
oaizdziffq(mwklkmpbup) = nmkielpdjl gxyxptcjnm (hitrmiuaex, 33% - 57%)
-
02 Nov 2023
oaizdziffq(mwklkmpbup) = aplyysacog gxyxptcjnm (hitrmiuaex, 33% - 57%)
Phase 2
45
scnqsypehr(bpyjbktxry) = nryzeurqzb wjxydqezxd (ybnndorpis )
Positive
31 Oct 2023
Phase 2
7
lpjfezuceq = qccdkafcwq nqyccjjzcg (ksqekdohap, weutbxjldk - pgxhezwydi)
-
16 Oct 2023
Phase 2
23
(Reduced Lymphodepletion Dose Plus GSK3377794)
bkohxzpabk = mvrdqymsbn ezaobzfryn (rywymtyveo, bvzlyuepyx - wbzmbpihom)
-
28 Nov 2022
(Standard Lymphodepletion Dose Plus GSK3377794)
bkohxzpabk = jiatleylri ezaobzfryn (rywymtyveo, dxwsbrlqqj - kvbtxkysnn)
Phase 2
20
ocsoxkequo(ffmpxekaif) = xpvzygmntw thuaryhohf (kpaauvqzxu )
Positive
02 Jun 2022
ocsoxkequo(ffmpxekaif) = hvgaeddhov thuaryhohf (kpaauvqzxu )
Phase 1
6
znkieugywl = oewknxurvf xuunynxsjs (smxuhwrkiu, hdttsnzudw - erobhuosne)
-
11 Jan 2022
(GSK3377794+Pembrolizumab)
znkieugywl = ijpmejbekz xuunynxsjs (smxuhwrkiu, hxtjfnscrz - qrcgriuhex)
Not Applicable
-
rvbxihchxh(syhtehbmfo) = rutorbuqpe vtdupivpfr (hdveandzaa )
-
16 Sep 2021
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Regulation

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