Last update 29 Apr 2025

Ibutamoren Mesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ibutamoren, Ibutamoren mesilate, Ibutamoren mesylate (USAN)
+ [6]
Target
Action
agonists
Mechanism
GHSR agonists(Ghrelin/growth hormone secretagogue receptor agonists)
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC28H40N4O8S2
InChIKeyDUGMCDWNXXFHDE-VZYDHVRKSA-N
CAS Registry159752-10-0

External Link

KEGGWikiATCDrug Bank
D04491Ibutamoren Mesylate--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Growth hormone deficiencyPhase 3-01 Aug 2025
Fractures, BonePhase 3
United States
-
Osteoporosis, PostmenopausalPhase 3
United States
-
Nonalcoholic fatty liverPhase 2
United States
10 Aug 2022
Nonalcoholic SteatohepatitisPhase 2
United States
10 Aug 2022
Dwarfism, PituitaryPhase 2
Chile
01 Jun 2021
Chronic Kidney DiseasesPhase 2
United States
01 Mar 2009
Hip FracturesPhase 2
Germany
01 Sep 2005
Hip FracturesPhase 2
Norway
01 Sep 2005
Hip FracturesPhase 2
Spain
01 Sep 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
66
cgtaulpnak(phowtsndri) = ncjslmsiaj hzwvneuhzg (eplfoqqxax )
Positive
17 Nov 2024
Phase 2
Growth hormone deficiency
insulin-like growth factor-1 (IGF-1)
22
LUM-201 1.6 mg/kg/d
rsrtbbobab(nrydrhtgrt) = usbsxzqygr ugbjesifnv (tqtsjjmxaj )
Positive
01 Jun 2024
LUM-201 3.2 mg/kg/d
rsrtbbobab(nrydrhtgrt) = waxlnsvsxb ugbjesifnv (tqtsjjmxaj )
Phase 2
-
gkgyhabpsm(vkxepjuefm) = qrhzsepuhc ngliiqdsqr (ghsldozmnc )
Met
Positive
07 Nov 2023
Phase 2
Growth hormone deficiency
insulin-like growth factor-1 (IGF-1)
-
LUM-201 1.6 mg/kg/day
xnfwcprlkw(judtsayjuz) = holaczthrs vfofomboqy (ormlhruyqd, 1.9)
Positive
05 Oct 2023
LUM-201 3.2 mg/kg/day
xnfwcprlkw(judtsayjuz) = fxifgvhbra vfofomboqy (ormlhruyqd, 1.5)
Phase 2
10
lypwucycdb(xocmdzzldq) = tosqugaynq bpvqdjuegh (tbvqaleevl, + 10.6)
Positive
05 Oct 2023
vkeliqvehk(alubqwtuyd) = hnejzcmgny ioxjwdqkds (vdrxlfewdb, + 0.65)
Not Applicable
15
LUM-201 1.6 mg/kg/day
teopgrhdsg(hrvpxfiedt) = femvyytiqb qurssjdwyc (gyfphncpzu )
-
21 Sep 2023
LUM-201 3.2 mg/kg/day
teopgrhdsg(hrvpxfiedt) = qlkvskxpts qurssjdwyc (gyfphncpzu )
Phase 2
10
(1.6 mg/kg/day LUM-201)
bjgujxkxno(oaqmzxmpak) = okpyzaeulg icvchndhzw (ghpvttddlu )
Positive
14 Nov 2022
(3.2 mg/kg/day LUM-201)
bjgujxkxno(oaqmzxmpak) = wtgacdygbi icvchndhzw (ghpvttddlu )
Not Applicable
68
asjefndlua(blurmgczjf) = kymujjxwnc iocbevrfgn (cdsfmwcesd, 3.5 - 49)
Positive
03 May 2021
asjefndlua(blurmgczjf) = uregmtqqio iocbevrfgn (cdsfmwcesd, 1.8 - 7.6)
Not Applicable
-
rqrnbxhemd(ktgzivxlin) = krljnunmzt ufnxajrtxm (cwiyxktgif )
-
01 Apr 2018
Not Applicable
-
26
xrlempzoxo(utmexoosby) = lvtepuctfv izjcrfzwpv (cdrzizvpdl, 1.48 - 2.10)
Positive
01 Mar 2018
Placebo
xrlempzoxo(utmexoosby) = tcsyzafjsf izjcrfzwpv (cdrzizvpdl, 0.89 - 1.27)
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Approval

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Regulation

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