A Single-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of 3,3'-Diindolylmethane (BR-DIM) in Patients With Systemic Lupus Erythematosus (SLE)

This is a single center study of patients with inactive or mild SLE being performed to determine the safety, tolerability, and pharmacodynamics of DIM.

Start Date01 Jan 2016

Sponsor / Collaborator

Northwell Health, Inc.

NCT01612910 / WithdrawnPhase 2IIT

A Pilot Study of BR-DIM in Women With Stage II-III, Triple Negative, and Androgen Receptor Positive, Invasive Breast Cancer, Who Have Residual Disease Following Surgical Resection After Neoadjuvant Chemotherapy

This study is being done to find out whether a nutritional supplement, called BioResponse-DIM (BR-DIM [oral microencapsulated diindolylmethane]), improves the survival for women who have residual cancer cells following surgery after chemotherapy for breast cancer. BR-DIM is an active ingredient in cruciferous vegetables (broccoli, brussels sprouts and cauliflower). Consumption of these vegetables has been associated with a decreased risk in several cancers. Researchers also hope to find out whether different biomarkers (also called "markers") in the blood predict the chance of breast cancer returning. BR-DIM is thought to be effective in treating stage II-III breast cancer that is triple negative, AR positive (+), and where there is residual cancer cells in the breast after chemotherapy.

Start Date01 Jun 2012

Sponsor / Collaborator

Barbara Ann Karmanos Cancer Institute

[+1]

NCT00450229 / CompletedPhase 1IIT

Phase Ib Placebo-Controlled Trial of Diindolylmethane (BR-DIM) in the Study of the Modulation of Intermediate Endpoint Markers in Patients With Prostate Cancer Who Are Undergoing Prostatectomy

Giving diindolylmethane, a substance found in cruciferous vegetables, may help doctors learn more about how diindolylmethane is used by the body. This randomized phase I trial is studying the side effects and best dose of diindolylmethane compared with a placebo in treating patients undergoing radical prostatectomy for stage I or stage II prostate cancer.

Start Date01 Feb 2007

Sponsor / Collaborator

National Cancer Institute

100 Clinical Results associated with Diindolylmethane

100 Translational Medicine associated with Diindolylmethane

100 Patents (Medical) associated with Diindolylmethane

613

Literatures (Medical) associated with Diindolylmethane

01 Feb 2025·BIOCHEMICAL PHARMACOLOGY

Implication of Let7b/AhR/ARNT/HMGB1/RAGE cascade in neuroplasticity disturbances induced by glucocorticoids and the promising reversible effect of 3,3 diindolymethane: Bidirectional crosstalk of Aryl hydrocarbon receptors

Article

Author: Azzam, May A ; Gad, Enas S ; Khidr, Haneen Y ; ElMonier, Asmaa A ; Abd-Elmawla, Mai A

Prolonged exposure to glucocorticoids (GC) disrupts neuronal architecture, hinders neuroplasticity, and triggers neuroinflammation. However, the precise underlying mechanisms have not been studied yet. The current study aimed to investigate the mechanisms of GC-induced neuroinflammatory effects by stimulating the miRNA let7b, aryl hydrocarbon receptor (AhR)/ARNT, HMGB1/RAGE, and other downstream targets. Rats were divided into 4 groups; control, GC (20 mg/kg, S.C.), 3,3'-diindolylmethane (DIM) 50 mg/kg/day, and donepezil (DNZ) 4 mg/kg/day for 21 days. Behavioral tests and histopathological investigations of cerebral cortex were done. Let7b, AhR, ARNT, and cytochrome A1A were estimated using qRT-PCR. HMGB1, RAGE, NQO1and NRF2 were estimated using ELISA, whereas GFAP and TNF-α by immunohistochemical analysis. Keap1 was estimated using Western technique. GSH and TBARS were assessed by colorimetric assay. In the current study, GC elevates the gene expressions of let7b, AhR, ARNT, and cytochrome A1A, along with the protein contents of HMGB1, RAGE, NQO1and NRF2. In addition, GC showed increased GFAP, TNF-α, and TBARS, together with decreased Keap1 and GSH. On the other side, DIM and DNZ reversed all the above-mentioned findings. Collectively, the study documents for the first time the effect of GC in upregulating let7b and activating the AhR/ARNT loop which subsequently stimulates RAGE/HMGB1 and NRF2/Keap1 cascade leading to stimulating further inflammatory and oxidative signaling pathways. Certainly, these effects are responsible for the behavioral fluctuations, the brain's histological disruption, altered neuroplasticity, and neuroinflammation induced by GC. Moreover, DIM conquers GC-induced neuroinflammation due to its characteristic role in modulating AhR and its downstream targets.

03 Dec 2024·ACS Omega

Silk Fibroin Nanoparticles as a Drug Delivery System of 3,3′-Diindolylmethane with Potential Antiobesogenic Activity

Article

Author: Morales-Martínez, Adriana ; Benavides, Jorge ; Rito-Palomares, Marco ; Lezama-Aguilar, David ; Lozano, Omar ; Mayolo-Deloisa, Karla ; Escobar-Fernández, Aleyda M. ; Sánchez-Trasviña, Calef ; Lorenzo-Anota, Helen Y. ; Vélez-Barceló, Ana

Obesity is a global disease characterized by excessive lipid accumulation in the adipose tissue. There is an urgent need to explore alternative compounds to treat obesity. Low-molecular-weight compounds from plants, like 3,3'-diindolylmethane (DIM), are emerging as potential alternatives for obesity treatment. In this work, DIM is encapsulated into silk fibroin nanoparticles (SFNP) to evaluate the antiobesogenic potential. The obtained spherical-like SFNPs have a particle size between 165 and 200 nm, a polydispersity index between 0.11 and 0.15, and a zeta potential from -27 to -37 mV. DIM does not modify the nanoparticle shape but changes the secondary structure of fibroin and generates smaller nanoparticles (145 nm). DIM-loaded SFNP (SFNP-DIM) enhance their antioxidant capacity by 4.4-fold compared to SFNP. SFNP-DIM does not show cytotoxicity on white-like adipocytes, unlike 3T3-L1 preadipocytes, where cell viability decreased in a concentration-dependent manner. The SFNP-DIM treatment (5 μM, 0.03 mg SFNP mL^-1) does not modify the morphology of white-like adipocytes. It produces an apparent augmentation in the size and number of intracellular lipid droplets and increases by 2.18 ± 0.4-fold of triglyceride content. These findings demonstrated that SFNPs could be a potential delivery system of DIM, suggesting a potential therapeutic agent for treating obesity.

01 Dec 2024·BIOCHEMICAL PHARMACOLOGY

3,3′-Diindolylmethane promotes bone formation – A assessment in MC3T3-E1 cells and zebrafish

Article

Author: Wang, Feng ; Tian, Xinyu ; Zhao, Guoyang ; Ye, Yang ; Huang, Lianlian ; Zhu, Yin ; Ma, Ying ; Wang, Dongxu ; Lu, Rongzhu

Osteoporosis is a common degenerative bone disease in middle-aged and elderly people. The current drugs used to treat osteoporosis have many side effects and low patient compliance. Phytochemotherapy may be safer and more effective. 3,3'-diindolemethane (DIM) is the digestive product of indole-3-methanol in cruciferous vegetables in the stomach, which is a kind of anti-tumor and anti-oxidation phytochemical. However, the effects of DIM on osteoblasts and the mechanism by which DIM regulates bone formation are not fully understood. The aim of this study was to investigate the effects of DIM on the bone formation of mouse preosteoblasts MC3T3-E1 and zebrafish. DIM promotes proliferation and osteogenic differentiation of MC3T3-E1 cells in vitro, and also plays a bone promoting role by increasing the interaction between BRCA1-Associated Protein 1(BAP1) and Inositol 1,4,5-Trisphosphate Receptor(IP3R), up-regulating the expression of BAP1 and IP3R and downstream storage operation calcium entry (SOCE) related protein Recombinant Stromal Interaction Molecule 1(STIM1). The effect of DIM on osteoporosis was confirmed in zebrafish osteoporosis model, and its molecular mechanism may be related to BAP1/IP3R/SOCE signaling pathway. These findings highlight the potential therapeutic value of DIM in the prevention and treatment of osteoporosis.

News (Medical) associated with Diindolylmethane

01 Dec 2023

·www.prnewswire.com

Maggie Q's ActivatedYou, Introduces the Latest Addition to Their Best-Selling Supplement, Morning Complete Mixed Berry Flavor

A Potent Daily Wellness Beverage Crafted to Enhance Digestive Function, Boost Energy Levels, and Promote Overall Well-Being LOS ANGELES, Dec. 1, 2023 /PRNewswire/ -- ActivatedYou® introduces a new flavor of their best-selling supplement: Morning Complete Mixed Berry. ActivatedYou Morning Complete is a daily wellness drink formulated with a thoughtfully selected blend of nutrients to help users begin each day with a healthy start and achieve their best state of well-being. This carefully crafted nutrient blend consists of 8 unique wellness-support blends designed to enhance your body's performance and help it function at its peak.†* Continue Reading ActivatedYou Morning Complete is a daily dietary supplement beverage that embodies "wellness in a glass." In addition to the new Mixed Berry flavor, Morning Complete comes in two other delicious flavors: Apple Cinnamon and Citrus Medley. What is ActivatedYou Morning Complete? ActivatedYou Morning Complete is a daily dietary supplement beverage that embodies "wellness in a glass." In addition to the new Mixed Berry flavor, Morning Complete comes in two other delicious flavors: Apple Cinnamon and Citrus Medley. This comprehensive formula combines metabolic support, probiotics, prebiotics, antioxidants, fiber-rich prebiotics, green superfoods, adaptogens, and liver support blends. By harnessing the power of nutrient-rich green vegetables, Morning Complete delivers essential fiber, probiotics, prebiotics, and health-supporting antioxidants. It actively nurtures gut health, fostering the growth of beneficial bacteria for a flourishing microbiome. With carefully selected ingredients that bolster holistic well-being, this blend supports liver and cellular function, supports your body's defenses against oxidative stress, and helps promote mental clarity.†* ActivatedYou Morning Complete Wellness Blend Ingredients Metabolic Enhancing Blend: Helps boost metabolism through the power of green tea leaves, ginger root, white tea leaves, turmeric root, bitter melon fruit, and black pepper fruit.†* Probiotic Blend: Supports a robust and diverse digestive environment by incorporating a spectrum of nine probiotic strains, including B. coagulans, L. gasseri, L. plantarum, L. rhamnosus, B. bifidum, B. longum, L. acidophilus, L. casei, and S. thermophilus.† Sugar Level Support: Supports healthy blood sugar levels already within normal range using a blend of Gymnema sylvestre leaves, fennel seeds, and pine bark extract.†* Green Superfoods Blend: Revitalize your body with spinach, broccoli, kale, mulberry leaf extracts, alfalfa leaves, and barley grass, providing essential nutrients and renewed energy.†* Antioxidant Blend: Assists your body in defending against environmental pollutants and oxidative stress by harnessing the polyphenol-rich lycium berries, pomegranate fruit extracts, and Polygonum cuspidatum root extracts (containing 50% resveratrol).†* Prebiotic and Fiber Blend: Nourishes your microbiome with vital support for beneficial gut bacteria, featuring a combination of chicory root fructooligosaccharides and cinnamon bark.†* Adaptogens: Supports your body's stress management with the use of adaptogens such as astragalus root extracts, Rhodiola rosea root extracts, and DIM (diindolylmethane).†* Liver Support Blend: Supports mitochondrial functions with organic aloe vera leaves and milk thistle seed extract, renowned for their positive impact on liver well-being.†* How to Use ActivatedYou Morning Complete To add ActivatedYou Morning Complete into your daily regimen, simply add one scoop of the easy-dissolve powder to the beverage of your choice. Maggie Q's ActivatedYou suggests mixing Morning Complete with 8oz of water or iced green tea. ActivatedYou Morning Complete can be purchased from the official ActivatedYou website. It is available for $79 and comes with a 90-day money-back guarantee (minus shipping), ensuring your satisfaction. About Maggie Q As a health advocate, animal rights activist, founder of fitness apparel brand Qeep Up, ActivatedYou founder, and actor—best known for her roles in Nikita, Designated Survivor, and Mission: Impossible III, Maggie Q uses her name to advocate for those in need. Maggie's personal health struggles led her to do extensive research in the world of nutrition and inspired her to create her own line of wellness supplements, ActivatedYou. Follow @maggieq on Instagram. About ActivatedYou ActivatedYou was founded by health advocate, animal rights activist, and actor Maggie Q, with Dr. Frank Lipman, a renowned gut-health expert and a pioneer of integrative medicine. ActivatedYou's unique formulas blend the latest in cutting-edge health and nutrition with age-old Eastern traditions and healthy ingredients for unique, effective formulas designed to help revolutionize health and improve lives. ActivatedYou's best-selling products include Advanced Restorative Probiotic, AdrenaLife, and Active Enzyme. To learn more about Maggie Q's ActivatedYou line, visit and follow @activatedyou on Instagram, @ActivatedYou on Twitter, and ActivatedYou on YouTube. *All individuals are unique. Your results can and will vary. Press Contact: Laura Baumgartner - Asylum PR [email protected] SOURCE ActivatedYou

12 Sep 2023

·www.prnewswire.com

Maggie Q's ActivatedYou® Morning Complete® Celebrates 3000+ Positive Reviews

ActivatedYou Morning Complete Supports Overall Well-Being With Eight Unique Wellness Blends LOS ANGELES, Sept. 12, 2023 /PRNewswire/ -- Morning Complete® by Maggie Q's ActivatedYou ® has now received over 3000 positive reviews across various platforms. This groundbreaking supplement was meticulously designed to support your holistic well-being. ActivatedYou Morning Complete combines the synergistic power of prebiotics, probiotics, and six carefully curated nutrient blends to support your metabolism, help facilitate weight management, and enhance your vitality.†* What is ActivatedYou Morning Complete?†* Continue Reading With two delicious flavors, Apple Cinnamon and the newer Citrus Medley, ActivatedYou Morning Complete daily drink is specially crafted to support overall well-being. Its comprehensive formula encompasses a range of powerful blends, including metabolic enhancement, prebiotic and high fiber, probiotic, antioxidant, green superfoods, adaptogens, liver support, and sugar-balancing support. ActivatedYou Morning Complete is a daily dietary supplement wellness beverage that encapsulates the essence of "wellness in a glass." Tailored to elevate overall well-being, this beverage is available in two tasty flavors: Apple Cinnamon and the newer Citrus Medley. Its comprehensive formulation blends metabolic reinforcement, probiotics, prebiotics, antioxidants, fiber-containing prebiotics, green superfoods, adaptogens, and liver support. Harnessing the power of nutrient-dense green vegetables, Morning Complete provides users with vital fiber, probiotics, prebiotics, and health-supportive antioxidants. It proactively nurtures gut health, cultivating advantageous bacteria for a flourishing microbiome. Through hand-selected ingredients that fortify holistic well-being, this formula supports liver and cellular function, your body's defenses to oxidative stress, a positive mood, and mental clarity. Ingredients in ActivatedYou Morning Complete†* Probiotic Blend: Fosters a thriving, digestive ecosystem with an array of 9 probiotic strains: B. coagulans, L. gasseri, L. plantarum, L. rhamnosus, B. bifidum, B. longum, L. acidophilus, L. casei, and S. thermophilus. Prebiotic and Fiber Blend: Enriches your microbiome with essential sustenance for beneficial gut bacteria, this blend includes chicory root fructooligosaccharides and cinnamon bark.† Green Superfoods Blend: Energizes your body with spinach, broccoli, kale, mulberry leaf extracts, alfalfa leaves, and barley grass, delivering vital nutrients and vitality.† Metabolic Enhancing Blend: Boosts metabolism with green tea leaves, ginger roots, white tea leaves, turmeric roots, bitter melon fruit, and black pepper fruit.† Antioxidant Blend: Helps your body combat environmental pollutants and oxidative stress with polyphenol-rich Lycium berries, pomegranate fruit extracts, and Polygonum cuspidatum root extracts (50% resveratrol).† Adaptogens: Aids your body's stress response by employing adaptogens like astragalus root extracts, Rhodiola rosea root extracts, and DIM (diindolylmethane).† Liver Support: Supports mitochondrial and detoxification functions with organic aloe vera leaves and milk thistle seed extracts, renowned for their positive impact on liver well-being.† Sugar Level Support: Supports healthy blood sugar levels already within normal range with this optimized performance blend of Gymnema sylvestre leaves, fennel seeds, and pine bark extracts.† How to incorporate ActivatedYou Morning Complete into your routine: To seamlessly integrate ActivatedYou Morning Complete into your daily regimen, simply add one scoop of the easy-dissolve powder to the beverage of your choice. Maggie Q's ActivatedYou suggests mixing Morning Complete with 8oz of water or iced green tea. Where to purchase ActivatedYou Morning Complete: You can conveniently buy ActivatedYou Morning Complete from the official ActivatedYou website. It is available for $79 and comes with a 90-day money-back guarantee (minus shipping), ensuring your satisfaction. Choose between two delightful flavors: apple cinnamon and the invigorating new citrus medley option. About Maggie Q As a health advocate, animal rights activist, the founder of fitness apparel brand Qeep Up, and actor—best known for her roles in Nikita, Designated Survivor, and Mission: Impossible III, Maggie Q uses her name to advocate for those in need. Maggie's personal health struggles led her to do extensive research in the world of nutrition and inspired her to create her own line of wellness supplements, ActivatedYou. Follow @maggieq on Instagram. About ActivatedYou™ ActivatedYou was founded by health advocate, animal rights activist, and actor Maggie Q, with Dr. Frank Lipman, a renowned gut-health expert and a pioneer of integrative medicine. ActivatedYou's unique formulas blend the latest in cutting-edge health and nutrition with age-old Eastern traditions and healthy ingredients for unique, effective formulas designed to help revolutionize health and improve lives. ActivatedYou's best-selling products include Advanced Restorative Probiotic, AdrenaLife, and Active Enzyme. To learn more about Maggie Q's ActivatedYou line, visit and follow @activatedyou on Instagram, @ActivatedYou on Twitter, and ActivatedYou on YouTube. *All individuals are unique. Your results can and will vary. †These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Press Contact: Laura Baumgartner - Asylum PR [email protected] SOURCE ActivatedYou

02 Aug 2023

·www.prnewswire.com

LEADING WOMEN'S HEALTH BRAND O POSITIV LAUNCHES OVARIAN SUPPORT VITAMIN CAPSULES

Supplements Support Ovarian and Reproductive Health and Aid in Regulating Menstrual Cycles LOS ANGELES, Aug. 2, 2023 /PRNewswire/ -- Today, O Positiv, the women's health brand behind FLO, the first-ever PMS support supplement on the market, introduces their newest product FLO Ovarian Support Vitamin Capsules. Continue Reading FLO Ovarian Support O Positiv's mission is to prioritize and advocate for women with effective products to address health concerns that have been historically overlooked. Since launching the FLO PMS Gummy in December 2018, O Positiv has positioned themselves as a premiere wellness brand with a range of products to address vaginal, digestive, skin, menstrual and menopausal health. Now, the brand is expanding from wellness supplements to a broader all-encompassing women's health company. O Positiv's co-founder, Brianna Bitton, was recently diagnosed with PCOS. Her struggle with painful and irregular periods continues to be a catalyst for the brand to launch much needed and effective products for women. More than 5 million women in the United States need help with Ovarian issues, especially women of reproductive age. For women suffering from hormonal imbalances, irregular periods and excess androgen levels, FLO Ovarian Support is designed to help using plant- based ingredients backed by science. "We made this product for the millions of women who know they need support for ovarian function," says co-founder Bobby Bitton, "And, so that millions more can begin the conversation with their doctors about the symptoms they're facing and how better ovarian support can help." Each FLO Ovarian Support Vitamin Capsule is formulated with the scientifically backed 40:1 ratio of Myo-Inositol and D-Chiro-Inositol to help support ovarian health and cycle regularity, folate to support reproductive health, and diindolylmethane (commonly known as DIM) to support healthy hormone levels. "Outside of cyclical PMS symptoms, hormone imbalances can cause irregular cycles and overactive hair growth. FLO Ovarian Support's ingredients help support healthy hormone levels," says Dr. Jessica Shepherd, OBGYN. "FLO Ovarian Support is great for patients who struggle with irregular cycles or overactive oil production on their face or scalp." O Positiv plans to continue expanding their range of products, which currently includes favorites - FLO PMS Gummies & Capsules, GOGO Prebiotic Fiber Gummies, URO Urinary Tract & URO Vaginal Probiotic Capsules, GOGO Bloating and Gas Capsules, MENO Menopause Gummies & Capsules and RETRO Glowing Skin Gummies & Capsules, among others. To further advocate for women's health, O Positiv works with the global nonprofit Period to end period poverty and stigma through service, education and advocacy. FLO Ovarian Support Vitamin Capsules retail $42.99 for a one-time purchase or subscription for $34.99 opositiv.com. About O Positiv O Positiv is the health and wellness brand prioritizing women by creating effective products to address health concerns that have been historically overlooked. O Positiv aims to break taboos with a line of products to address vaginal, skin, digestive, menstrual and menopausal health. For more information, visit opositiv.com. Follow O Positiv on Instagram at @opositiv Press Contact: Shauna Aminzadeh/Break Point [email protected] SOURCE O Positiv

100 Deals associated with Diindolylmethane

External Link

KEGG	Wiki	ATC	Drug Bank
-	Diindolylmethane	-	DB11875

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Uterine Cervical Cancer	Phase 3	-	National Cancer Institute	-
Triple Negative Breast Cancer	Phase 2	-	National Cancer Institute	01 Jun 2012
Adenocarcinoma of prostate	Phase 1	US	National Cancer Institute	01 Feb 2007
Castration-Resistant Prostatic Cancer	Phase 1	US	National Cancer Institute	01 Aug 2005
Psoriasis	Preclinical	IN	VIT University	11 Apr 2024
Metastatic Prostate Carcinoma	Preclinical	US	Wayne State University School of Medicine	01 May 2005

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


AACR2012	Not Applicable	-	-	Cisplatin	wulhenafxa(gguuvctjuo) = inobnjugsu spsmcpurrq (skyaywmfae )	-	15 Apr 2012
				Gemcitabine	wulhenafxa(gguuvctjuo) = fwqfboddeu spsmcpurrq (skyaywmfae )
ASTRO	Not Applicable	Castration-Resistant Prostatic Cancer	-	B-DIM	hprhukiegw(jbjmhfvsnw) = yufmyllspv cdjjkrqnni (wjnaauydim )	-	01 Oct 2011
				B-DIM (Radiation)	hprhukiegw(jbjmhfvsnw) = lpuipnpnzw cdjjkrqnni (wjnaauydim )

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis