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Immune System Diseases

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Skin and Musculoskeletal Diseases

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Disease Domain	Count

Immune System Diseases	1
Neoplasms	1

Top 5 Drug Type	Count

Small molecule drug	1

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AR x HDACs x KLK3	1

A Knoevenagel condensation reaction paved the way for the development of the PTZ-BCN probe namely (z)-2-(1H-benzo[d]imidazole-2-yl)-3-(10-ethyl-10H-phenothiazin-3-yl) acrylonitrile. PTZ-BCN's spectral characteristics were verified through the application of IR, ¹H NMR, ¹³C NMR, and HRMS techniques. The PTZ-BCN probe showed a high selectivity and sensitivity toward Hg²⁺ ions over other interfering competing metal ions in CH₃CN: HEPES buffer (9:1, v/v) system. The addition of Hg²⁺ results in a notable redshift and fluorescence quenching of the PTZ-BCN probe. An examination of the interaction between the PTZ-BCN probe and Hg²⁺ involved recoding ¹H NMR titration spectra, HRMS, DFT analysis, and Job's plot respectively. Quantification of the lowest detectable Hg²⁺ concentration at 2.3 nM, exhibiting a correlation coefficient of R² = 0.9985. PTZ-BCN probe has proven effective in quantitatively determining the existence of Hg²⁺ in real-time water samples, test strips, solid state, and Hela living cells.

01 Jan 2025·Current Nutrition & Food Science

A Comprehensive Review of Food Recommendation Systems in the Context of Nutritional Therapy for Diabetes Mellitus

Author: Kakani, Vijay ; Chagalasetty, Sreelasya ; Prabakaran, N. ; Rajan, Nitya

Abstract::Food recommendation systems (FRS) have gained prominence for providing personalized dietary recommendations. This paper explores the integration of FRS and nutritional therapy to enhance the management of diabetes mellitus. Nutritional therapy plays a crucial role in controlling blood glucose levels and reducing complications in diabetes. The study reviews and analyzes various food recommendation models in diverse scenarios of diabetic nutritional therapy. By considering specific needs and constraints, the strengths of each model are assessed, leading to the identification of the most suitable model for each scenario. The findings contribute to improving the quality of dietary guidance for individuals with diabetes.

01 Jan 2025·Journal of Photochemistry and Photobiology A: Chemistry

Thiazole-derived pyrazin-2-carbohydrazide chemosensors: Colorimetric & photoluminescent detection of silver ions for theoretical, environmental, and cell imaging

Author: Dhanasekaran, Kumudhavalli ; Mohandoss, Sonaimuthu ; Napoleon, Ayyakannu Arumugam ; Beena, Maya ; Ilakiyalakshmi, Mohan ; Palaniappan, Arunkumar

In this work, a simple and versatile chemosensor receptor TZPYZ was synthesized through the combination of thiazole with pyrazine-2-carbohydrazide, resulting in a confirmed chem. structure via various anal. techniques including FT-IR, ¹H, and ¹³C NMR Spectroscopy, as well as High-Resolution Mass Spectroscopy anal.TZPYZ exhibits specific colorimetric and photoluminescent responses to Ag⁺ ions in a solvent solution consisting of DMSO and H₂O (7:3, volume/volume).Upon addition of Ag⁺ ions, noticeable changes in absorption spectra occur, resulting in a visible color change from pale yellow to blue.Addnl., an enhanced emission intensity with wavelength at 523 nm, when excited at 410 nm.Notably, TZPYZ demonstrated exceptional selectivity for Ag⁺ ions over other metal cations, achieving a detection limit (LOD) of 10.6 x 10^-9 M and 6.74 x 10^-9 M and using the UV-visible & photoluminescent titration method.Interference studies indicated minimal disruption from other metal ions on emission at 523 nm, highlighting TZPYZ discerning capability for Ag⁺ ions.With a binding affinity of 3.622 x 10^-11 M^-1, TZPYZ proved effective in detecting Ag⁺ ions across various water samples, showcasing its practical utility.The mechanism of interaction between TZPYZ and Ag⁺ ions was investigated using various exptl. techniques, including Job′s plot, Benesi-Hildebrand investigations, ¹H NMR, and HRMS anal.Test strips coated with TZPYZ showed selective detection of Ag⁺ ions, indicating its potential for on-site applications.Furthermore, DFT computations provided insights into the structural and electronic properties of TZPYZ and its complex with Ag⁺ ions, further elucidating the binding mechanism and stability of the complex.In addition, TZPYZ demonstrated compatibility with biol. systems, as fluorescence imaging tests on MCF-7 breast cancer cells confirmed both its non-cytotoxic nature and its proficiency in detecting intracellular silver ions.Based on these findings, TZPYZ is highlighted as a highly sensitive and selective chemosensor for Ag⁺ ions, with promising applications in environmental anal. and bioimaging.

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Pipeline

Pipeline Snapshot as of 25 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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