Last update 16 May 2024

Vadadustat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
伐度司他
+ [6]
Target
Mechanism
HIF-PHs inhibitors(Hypoxia-inducible factor prolyl hydroxylase inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
JP (29 Jun 2020),
Regulation-
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Structure

Molecular FormulaC14H11ClN2O4
InChIKeyJGRXMPYUTJLTKT-UHFFFAOYSA-N
CAS Registry1000025-07-9

External Link

KEGGWikiATCDrug Bank
D11078--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anemia in chronic kidney disease
US
27 Mar 2024
chronic renal failure anemia
NO
24 Apr 2023
chronic renal failure anemia
EU
24 Apr 2023
chronic renal failure anemia
IS
24 Apr 2023
chronic renal failure anemia
LI
24 Apr 2023
Anemia of renal disease
JP
29 Jun 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic Kidney DiseasesPhase 2
US
01 Dec 2015
Anemia of renal diseasePhase 1
US
30 Mar 2021
Chronic Kidney DiseasesPhase 1
US
01 Dec 2015
Chronic Kidney DiseasesPreclinical
AU
01 Dec 2015
Chronic Kidney DiseasesPreclinical
AU
01 Dec 2015
Chronic Kidney DiseasesPreclinical
NZ
01 Dec 2015
Chronic Kidney DiseasesPreclinical
MY
01 Dec 2015
Chronic Kidney DiseasesPreclinical
IL
01 Dec 2015
Chronic Kidney DiseasesPreclinical
MY
01 Dec 2015
Chronic Kidney DiseasesDiscovery
IL
01 Dec 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
304
(droxvzsvtv) = ppezbevywt megafjfhma (hewdajqqdb, 11.49 ~ 11.84)
Non-inferior
21 Apr 2021
Darbepoetin Alfa
(droxvzsvtv) = csabawwyvc megafjfhma (hewdajqqdb, 11.76 ~ 12.10)
Phase 2
449
ctzuxguuqt(qwyuyhcbhx) = vrxaxxthdh ynbnzdznbk (wnvkypuryi )
Negative
04 Aug 2022
Placebo
ctzuxguuqt(qwyuyhcbhx) = iyldbvyaqe ynbnzdznbk (wnvkypuryi )
Phase 3
3,923
(raallqobuu): difference = -0.31 (95% CI, -0.53 to -0.10)
Non-inferior
29 Apr 2021
Darbepoetin alfa
Phase 3
3,471
(winrubxyzk): difference = -0.01 (95% CI, -0.09 to 0.07)
Non-inferior
29 Apr 2021
Darbepoetin alfa
Phase 2
93
-
Positive
01 Jan 2017
Placebo
EMA
ManualManual
Not Applicable
3,923
(INNO2VATE 1)
(wzwlaiuuav) = kxvqtdrhgy jjekmkjdzo (cwhenbxpqn, 9.23 - 11.49)
Positive
31 May 2023
(INNO2VATE 1)
(wzwlaiuuav) = iikvgvycoq jjekmkjdzo (cwhenbxpqn, 9.67 - 11.55)
Phase 3
24
(jkwppecjio) = hrqhsjyftt lufeidgvfn (yevdtnbixf, 10.35 - 11.14)
Positive
11 Jun 2021
Phase 3
42
(maqcwzyalk) = fzjecfsrgr kgciidqdkp (hzoijbeohv, 10.99 ~ 11.70)
Positive
12 Mar 2019
Phase 3
3,923
(msgpvaskhe) = mpmcofcing ffeviplypp (dqgzgzqjlb, 1.1)
Non-inferior
27 Mar 2024
(msgpvaskhe) = jdlagdettz ffeviplypp (dqgzgzqjlb, 0.9)
Phase 3
323
(xgafvflpqb) = xsmmyrzcmy isufvbnrpo (nrvlxdeajj, 10.45 ~ 10.76)
Positive
27 Aug 2021
darbepoetin alfa
(xgafvflpqb) = jlhryeqlbd isufvbnrpo (nrvlxdeajj, 10.50 ~ 10.80)
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Clinical Trial

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Approval

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Regulation

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