Ginkgo Biloba leaves Extract

The goal of this work is to evaluate the greenness of six spectrophotometric approaches that have been presented for determining the binary combination of levamisole (LVA) and triclabendazole (TCZ).To evaluate the suggested approaches, the anal. community has taken an interest in using green anal. chem. practices.Two tools, called "Anal. GREEness" (AGREE) and "Green Anal. Procedure Index" (GAPI), were utilized to assess the degree of greenness.The zero spectrum of TCZ and LVA is compared, and it is seen that their spectra overlap.This means that the six spectrophotometric methods can be used to find them: zero order (D0), first derivative (D1), second derivative (D2), the area under the curve (AUC), mean centering, and bivariate.Method I: The zero-order method (D0) is used to measure TCZ directly at 306 nm because LVA has no absorption.Method II: the first derivative method (D1) was used at wavelengths of 312 nm and 220 nm for TCZ and LVA resp., and the linear range for TCZ and LVA was 2-18 μg/mL and 2-14 μg/mL, resp.Method III: For the TCZ, the second derivative method (D2) was used at a wavelength of 312 nm and a linear range of 1-18 μg/mL.Method IV: The area under the curve (AUC) method was used with wavelengths of 202-207 nm and 218-226 nm, and concentrations of 2-14 μg/mL for LVA and 1-9 μg/mL for TCZ.Method V: we used a mean-centering method that involved dividing the mean-centered ratio spectrum by the spectrum of the 6 μg/mL TCZ and finding the mean-centered ratio values at 241 nm for LVA.Method VI: The bivariate method is based on measuring two components at two chosen wavelengths using the Kaiser Method.The wavelengths 215 and 225 nm gave the best value of K, so they could be used to find the concentrations of LVA and TCZ.It ranged from 2 to 16 μg/mL for TCZ and from 2 to 14 μg/mL for LVA.These methods were developed for analyzing binary mixtures in pharmaceutical dosage form and bulk powders with high recoveries.Following ICH guidelines, the developed techniques underwent validation.The results show that there were no significant differences when all methods were compared statistically to the described method for TCZ and LVA.

A new Co(II) complex, [Co(NCS)2(L)2] (1) has been synthesized based on levamisole (L) as a new ligand. Single‐crystal X‐ray diffraction analyses confirm that the Co(II) ion is having a distorted tetrahedral coordination geometry in the complex. Notably strong intramolecular S⋅⋅⋅S and S⋅⋅⋅N interactions has been confirmed by employing Quantum Theory of Atoms in Molecules (QTAIM). These intramolecular interactions occur among the sulfur and nitrogen atoms of the levamisole ligands and also the nitrogen atoms of the thiocyanate. Direct current (dc) magnetic analyses reveal presence of zero field splitting (ZFS) and large magnetic anisotropy on Co(II). Detailed ab initio ligand field theory calculations quantitatively predicted the magnitude of ZFS. Prominent field‐induced single‐ion magnet (SIM) behavior was observed for 1 from dynamic magnetization measurements. Slow magnetic relaxation follows an Orbach mechanism with the effective energy barrier Ueff=29.6 (7) K and relaxation time τo=1.4 (4)×10−9 s.