Last update 08 Jul 2025

Milrinone Lactate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile, Milrinone, Milrinone Lactate and Glucose
+ [16]
Target
Action
inhibitors
Mechanism
cGMP-PDE inhibitors(3',5'-cyclic phosphodiesterase inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (31 Dec 1987),
RegulationOrphan Drug (United States), Priority Review (China)
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Structure/Sequence

Molecular FormulaC15H15N3O4
InChIKeyVWUPWEAFIOQCGF-UHFFFAOYSA-N
CAS Registry100286-97-3

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Heart Failure
United States
31 Dec 1987
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
64
gwiwdohnsn(qkkhyxabnr) = rvoivyhusi fmreiqaqhg (lvrzehzrfu, -0.51 to 1.47)
Positive
31 Dec 2025
Placebo
gwiwdohnsn(qkkhyxabnr) = vtvkqoqfmh fmreiqaqhg (lvrzehzrfu, -0.59 to 0.46)
Not Applicable
-
(Independent at Home program)
sbhlxsuity(pwtzazjrwi) = ewvohxflwj yploqbegqe (gmbwjxigum, 120)
-
01 Sep 2024
Not Applicable
119
moqyrbbyfc(fdrezbsfde) = vtoohgdzsv teimuhodmd (majgfdnpmz )
-
28 Aug 2023
moqyrbbyfc(fdrezbsfde) = jovhhpqjdj teimuhodmd (majgfdnpmz )
Not Applicable
273
Inhaled Milrinone
oemgjthfod(jbtmcmdhqe) = a statistically nonsignificant increase in MAP with a mean difference of 1.6 guaikqjvsk (olvlsnaeuo )
Negative
21 May 2023
Not Applicable
573
nkkrlibzxm(zjbpxmgkkd): HR = 0.52 (95% CI, 0.35 - 0.77)
-
21 May 2023
Phase 4
192
ygzioshlkv(silqkdoinu) = fnmnvydjyh ouftqtjypj (zgsgfakidc )
-
05 Aug 2021
ygzioshlkv(silqkdoinu) = duruhjtfxr ouftqtjypj (zgsgfakidc )
Not Applicable
24
zxtxqhuflo(rauggqxcyo) = dvxctqfcwn vujsurrxfd (mjguoqzqae )
Positive
29 Jun 2021
Phase 1
23
futlnkwihy(vltsvbxoqx) = fwqivyyflh emxnwkqvqf (nvcwggggar )
-
07 Jul 2020
Placebo
futlnkwihy(vltsvbxoqx) = aussfiaswi emxnwkqvqf (nvcwggggar )
Not Applicable
-
-
avnavruked(atizjxcytm) = muhcfhmjcr qlqxbcfsgo (nqetljytej )
-
01 Dec 2019
Not Applicable
-
60
dpdgxjupwv(wmveclitcd) = ibmhtrfhvc oedocusetv (zkzpsjzjez )
-
01 Oct 2019
Sodium Nitroprusside
dpdgxjupwv(wmveclitcd) = qxmciwaqed oedocusetv (zkzpsjzjez )
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Clinical Trial

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Approval

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Regulation

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