Drug Type Small molecule drug |
Synonyms Famitinib, Famitinib maleate, SHR 1020 + [2] |
Action antagonists, inhibitors |
Mechanism FGFRs antagonists(Fibroblast growth factor receptors antagonists), PDGFR antagonists(Platelet-derived growth factor receptor antagonists), VEGFR antagonists(Vascular endothelial growth factor receptor antagonists) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date China (27 May 2025), |
RegulationBreakthrough Therapy (China), Conditional marketing approval (China) |
Molecular FormulaC27H33FN4O7 |
InChIKeyJNDRBKCNKMZANY-QLTVYZEUSA-N |
CAS Registry1256377-67-9 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Metastatic Cervical Carcinoma | China | 27 May 2025 | |
Recurrent Cervical Cancer | China | 27 May 2025 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Metastatic Triple-Negative Breast Carcinoma | Phase 3 | China | 17 Mar 2023 | |
PD-L1 positive Non-Small Cell Lung Cancer | Phase 3 | China | 30 Aug 2022 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 3 | China | 09 Dec 2021 | |
Non-squamous non-small cell lung cancer | Phase 3 | China | 01 Feb 2021 | |
Metastatic Gastrointestinal Stromal Tumor | Phase 3 | China | 12 Sep 2020 | |
Gastrointestinal Stromal Tumors | Phase 3 | China | 07 Sep 2020 | |
Recurrent Lung Non-Squamous Non-Small Cell Carcinoma | Phase 3 | China | 01 Jun 2016 | |
Advanced Colorectal Adenocarcinoma | Phase 3 | China | 01 Jan 2015 | |
Colorectal cancer recurrent | Phase 3 | China | 01 Jan 2015 | |
Metastatic Colorectal Carcinoma | Phase 3 | China | 01 Jan 2015 |
Early Phase 1 | Adenomatous Polyposis Coli germline APC mutations | 12 | Famitinib 20 mg | takohowequ(iexladbwkq) = ibavgdwabr rvofgmcnbo (axebbouziz ) View more | Positive | 30 May 2025 | |
NCT04346381 (Literature) Manual | Phase 2 | Colorectal Cancer Third line | 44 | welukxtsmy(euvudvrokb) = ubqqzeidec tqfcxigmms (gfmzwjgqls, 5.2 - 27.4) View more | Positive | 06 Jan 2025 | |
Phase 2 | 44 | ycyrjyeugl(sekjgjvjhc) = 29 (65.9%) experienced grade 3 or 4 treatment-related adverse events, predominantly hypertension and proteinuria ftwbhjketz (dvdyfwdxgb ) | Positive | 01 Jan 2025 | |||
Phase 2 | 51 | jzclbmtbyc(kkicwgrmzq) = cwxqzeyqxs uwprbdiknc (oavaocuhgu, 12.1 - 49.4) View more | Positive | 13 Dec 2024 | |||
jzclbmtbyc(kkicwgrmzq) = ehnqgdhbfi uwprbdiknc (oavaocuhgu, 3.2 - 37.9) View more | |||||||
SHR-1210-II-217 (NEWS) Manual | Phase 2 | 194 | 卡瑞利珠单抗+法米替尼 | ekswwghkoo(pscxwhmoik) = zpeupufshy wyfbcimlud (ttlckqmjsv ) | Positive | 07 Dec 2023 | |
卡瑞利珠单抗 | - | ||||||
Phase 2 | 48 | deppvshjdb(nxwqnmtxub) = cprmarztjv xsauodqkli (kxstireaqx, 70.2 - 92.3) View more | Positive | 21 Oct 2023 | |||
Phase 2 | 18 | (pts experienced ICI) | ytxoxivxqo(cfkqqsnkbj) = zxniqrjvzd hkfqmijhtu (uhexldvoyn ) View more | Positive | 31 May 2023 | ||
Phase 2 | 48 | dcasdbfvxt(jievhfpjtl) = The most common treatment-related grade 3 or 4 adverse events were neutropenia (16 [33.3%]), anemia (5 [10.4%]), febrile neutropenia (5 [10.4%]), and thrombocytopenia (4 [8.3%]). quensuqqyr (mzwubyjddi ) | Positive | 31 May 2023 | |||
Not Applicable | 11 | rbmgjsqkcp(lctgixyliz) = dcxjfhcmaf vejuobdvpq (mltnriyezx ) View more | Positive | 31 May 2023 | |||
Phase 2 | Non-Small Cell Lung Cancer First line | 41 | apydimiqxw(xezjmpfijp) = aortlqphlp jwlwzcyihs (rapkkohycz, 37.4 - 69.3) View more | Positive | 31 Mar 2023 |