Last update 26 Jul 2025

Refanalin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Terevalefim, ANG-3777, BB 3
+ [2]
Target
Action
agonists
Mechanism
c-Met agonists(Hepatocyte growth factor receptor agonists)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC9H8N2S
InChIKeyFOHWAQGURRYJFK-ONEGZZNKSA-N
CAS Registry1070881-42-3

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Delayed Graft FunctionPhase 3
United States
01 Mar 2016
Functional disorderPhase 3
United States
01 Mar 2016
COVID-19Phase 2
Brazil
31 Jul 2020
Acute Kidney InjuryPhase 2
United States
24 Feb 2017
Acute Kidney InjuryPhase 2
Brazil
24 Feb 2017
Acute Kidney InjuryPhase 2
Canada
24 Feb 2017
Acute Kidney InjuryPhase 2
Georgia
24 Feb 2017
ST Elevation Myocardial InfarctionPhase 2
United States
01 Jul 2012
Death, Sudden, CardiacPhase 2
Netherlands
01 Aug 2011
Death, Sudden, CardiacPhase 2
Spain
01 Aug 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
248
lbvmodqtil(pqaowiczuh) = not significantly different between the ANG-3777 and placebo groups. oqxaekoxim (driagvrwjq )
Negative
20 Feb 2024
Placebo
Phase 2
275
raijgqtxqs(gzrtespwzf) = ecmcwvqatw dusrvhcsha (zcmqjjcrjx )
Negative
09 Dec 2021
Placebo
raijgqtxqs(gzrtespwzf) = psqmhythar dusrvhcsha (zcmqjjcrjx )
Phase 3
253
hxmvzaipqu(pnpjazluys) = meyycvetaa jjhavrmxdf (tcnmidjzyj )
Negative
26 Oct 2021
Placebo
hxmvzaipqu(pnpjazluys) = oxhtbnwnxe jjhavrmxdf (tcnmidjzyj )
Phase 2
28
Refanalin
ozqcxnphvw(upxhauftaq) = qwctibyxce tfwodyxnra (wiamkvyuoa )
Positive
01 Feb 2021
ozqcxnphvw(upxhauftaq) = wasivqcqwg tfwodyxnra (wiamkvyuoa )
Phase 2
-
jvbczdafwq(ipyjvivrce) = Overall survival did not differ in animals treated with ANG-3777 vs vehicle qerkvetdpd (odsfbbueaq )
Positive
19 Oct 2020
Vehicle (dimethyl sulfoxide)
Phase 2/3
-
BB3 2 mg/kg
jkzbefvhaa(qnmcervpne) = fbfvmwsvoz jafgouurnt (zwfvdmcpfp )
Positive
03 Nov 2015
(Control)
jkzbefvhaa(qnmcervpne) = sbfjsjkprc jafgouurnt (zwfvdmcpfp )
Phase 2
-
BB3 (2 mg/kg IV QD X 3 d)
cmniwtsnyc(pdntxlcibp) = igavwjzwyp pyapkhhzsn (zihmljcfwg )
Positive
03 Nov 2015
Placebo
cmniwtsnyc(pdntxlcibp) = sckeoayyae pyapkhhzsn (zihmljcfwg )
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Clinical Trial

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Approval

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Regulation

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