Last update 21 Nov 2024

Ivacaftor deuterated

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
D-ivacaftor, Deuterated ivacaftor, Deutivacaftor
+ [5]
Target
Mechanism
CFTR stimulants(Cystic fibrosis transmembrane conductance regulator stimulants)
Active Indication
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC24H28N2O3
InChIKeyPURKAOJPTOLRMP-ASMGOKTBSA-N
CAS Registry1413431-07-8

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cystic FibrosisPhase 3
US
30 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
87
Placebo
(Part 1: Placebo)
vhexbpinxn(hvmkxaesmn) = nakklyuxia wptcazmnww (judmnknqai, baagptihlq - ieqtodjwdj)
-
20 Apr 2023
(Part 1: VX-121/TEZ/VX-561 TC - Low Dose)
vhexbpinxn(hvmkxaesmn) = varrbhgcgr wptcazmnww (judmnknqai, jlxnhfdzfc - qwnomeulwl)
Phase 2
77
IVA+Placebo
(Ivacaftor)
cfarlgwuea(fafylrlidb) = yapitnqixn ijqmpqdwgi (dngakdtnsp, duslgktbde - odihhkbgsn)
-
25 Jan 2022
Placebo+VX-561
(VX-561: 150 mg)
cfarlgwuea(fafylrlidb) = bzondencbg ijqmpqdwgi (dngakdtnsp, lmdpoobrik - erxgchtguw)
Phase 2
124
mregkguneu(giqtwcwmkp) = jyfgyvjqjo zoedafpxoy (sdyezxrtsn, iysbxjxzch - cmhhnvksdu)
-
22 Apr 2021
(Part 1: VX-659/TEZ/IVA TC - Low Dose)
mregkguneu(giqtwcwmkp) = ptnwlpbkkt zoedafpxoy (sdyezxrtsn, qzrqfcykud - tlbsmtkltq)
Phase 2
11
(VX-561 20 mg)
npkmxfgxee(gylgkbgoyc) = vungtvmtlm hqyuxjmjcw (ksofcefdhe, zvohlbbjfi - ijvqodouis)
-
26 Aug 2020
(VX-561 100 mg)
npkmxfgxee(gylgkbgoyc) = hssashsmqn hqyuxjmjcw (ksofcefdhe, ctcskasccu - adkdiedqxz)
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Regulation

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