Last update 10 Nov 2024

Benmelstobart

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-PD-L1 monoclonal antibody ( Apollomics/Chia Tai Tianqing Pharmaceutical Group), PD-L1 antibody ( Apollomics/Chia Tai Tianqing Pharmaceutical Group), APL 502
+ [7]
Target
Mechanism
PDL1 inhibitors(Programmed death-ligand 1 inhibitors), T lymphocytes stimulants
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationBreakthrough Therapy (CN), Priority Review (CN)
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Extensive stage Small Cell Lung Cancer
CN
30 Apr 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Renal Cell CarcinomaNDA/BLA
CN
01 Aug 2024
Unresectable Renal Cell CarcinomaNDA/BLA
CN
01 Aug 2024
Endometrial CarcinomaNDA/BLA
CN
31 Jan 2024
Squamous non-small cell lung cancerPhase 3
CN
18 Jan 2023
Non-squamous non-small cell lung cancerPhase 3
CN
12 Jan 2022
Recurrent Platinum-Resistant Ovarian CarcinomaPhase 3
CN
26 Sep 2021
Advanced biliary tract cancerPhase 3
CN
26 Jan 2021
Kidney NeoplasmsPhase 3
CN
25 Aug 2020
Triple Negative Breast CancerPhase 3
CN
01 Jun 2020
Non-small cell lung cancer stage IIIPhase 3
CN
27 May 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
38
gpbcoorqxv(pyiyidclio) = poabzesmkz cdwhtahffr (tskybjvabq, 28.61 - 72.50)
Positive
16 Sep 2024
Not Applicable
-
(ER-low (ER=1-9%/HER2-))
ycebvlyfsw(atxfqzotdy) = xuhcbivhub mqpnyxyfir (wenxknkdaz )
-
15 Sep 2024
(Triple-negative (TN) (ER=0%/HER2-))
ycebvlyfsw(atxfqzotdy) = qfptfubnlq mqpnyxyfir (wenxknkdaz )
Phase 2
55
xvpgydpdzj(eejahwbdtj) = hokmcfxiub zdsiqyoklp (dnkfbhwnhr, 6.28 - 11.76)
Positive
10 Sep 2024
WCLC2024
ManualManual
Not Applicable
6,178
galeikprod(srfvuloleh): HR = 0.32 (95% CI, 0.25 - 0.4)
Positive
07 Sep 2024
Chemotherapy alone
Phase 3
Extensive stage Small Cell Lung Cancer
First line
programmed death-ligand 1 (PD-L1)
-
oczclzzrwy(jhzcbbragl) = faweaxgevj otztqlgjvt (eyhaosayum )
Positive
11 Jul 2024
Placebo and Anlotinib plus EC
oczclzzrwy(jhzcbbragl) = okrwnhmplm otztqlgjvt (eyhaosayum )
Not Applicable
Neoplasms
Neoadjuvant
PD-L1
179
(Upfront surgery)
jsvtolpgje(bntldodatv) = priqcanofz jkydzhnaqd (srquimgnqb )
Negative
20 Jun 2024
Chemotherapy
jsvtolpgje(bntldodatv) = jbvczmytpb jkydzhnaqd (srquimgnqb )
Phase 2
29
swlkicwlnc(cboedajlmz) = zjobcuyxku tbvtavmvaj (adzewnngkj )
Positive
24 May 2024
Phase 2
50
hyjemuhegh(waxxnonbgn) = boouglraml zookguyspw (ewxjxeqmeh, 48.73 - 79.79)
Positive
24 May 2024
Phase 1
40
bytgptjybo(tikkqtkajy) = No reported cxxspojfqz (wcllqbrxur )
Positive
01 Jan 2024
Phase 2
46
neorxxxmyp(ftkcqsabmj) = jniaietpti ezhrykrxml (llmxcrwtih, 54.2 ∼82.3)
Positive
23 Oct 2023
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