Delving into the Latest Updates on Autologous Adipose tissue derived Mesenchymal Stem Cells(R Bio) with Synapse

Overview

Basic Info

Drug Type

Stem cell therapy

Synonyms

JointStem

Target-

Mechanism-

Therapeutic Areas

Skin and Musculoskeletal Diseases

Active Indication

Osteoarthritis

Inactive Indication

Spinal Cord Injuries

Originator Organization

R Bio Co., Ltd.

Active Organization

R Bio Co., Ltd.

Inactive Organization-

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

This study is a double-blind, randomized, placebo controlled, multi-center, superiority study to evaluate the efficacy and safety of JointStem, autologous adipose tissue derived mesenchymal stem cells (AdMSC), in patients diagnosed as knee osteoarthritis. Following a 2-week screening period, approximately 140 subjects will be randomly assigned into one of the following two arms in a 1:1 ratio (1 JointStem : 1 Placebo). After each subject completes 48-Weeks visit (Visit 8) and the data management team confirms all individual data have no issue, the individual database will be locked and the blinding will be open for the statistical analysis.

Start Date26 May 2021

Sponsor / Collaborator

Naturecell. Co., ltd.

IRCT2016111427865N2 / CompletedPhase 1/2IIT

Evaluation of the safety and feasibility of intra-arterial injection of autologous stem cells derived from adipose tissue in stroke patients.

Start Date21 Dec 2016

Sponsor / Collaborator-

JPRN-UMIN000024133 / Completed

Clinical research (COPD) using autologous fat tissue from the mesenchymal stem cells - Clinical research (COPD) using autologous fat tissue from the mesenchymal stem cells

Start Date29 Jul 2016

Sponsor / Collaborator-

100 Clinical Results associated with Autologous Adipose tissue derived Mesenchymal Stem Cells(R Bio)

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100 Translational Medicine associated with Autologous Adipose tissue derived Mesenchymal Stem Cells(R Bio)

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100 Patents (Medical) associated with Autologous Adipose tissue derived Mesenchymal Stem Cells(R Bio)

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100 Deals associated with Autologous Adipose tissue derived Mesenchymal Stem Cells(R Bio)

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Osteoarthritis	Phase 2	US	R Bio Co., Ltd.	12 Oct 2022
Osteoarthritis	Phase 2	KR	R Bio Co., Ltd.	12 Oct 2022
Spinal Cord Injuries	Phase 1	-	R Bio Co., Ltd.	01 Jul 2009

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Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03000712 (Pubmed) Manual	Not Applicable	Osteoarthritis, Knee	26	MOWHTO+ADMSC	gjtonjfexb(cwvvpvqyxj) = cdfphsumzm jbzjsnymva (dwgorhqtgl, 23.6) View more	Positive	08 Jun 2022
				MOWHTO	gjtonjfexb(cwvvpvqyxj) = cuhzqnspzg jbzjsnymva (dwgorhqtgl, 28.9) View more
NCT02658344 (Pubmed \| Stem Cells Transl Med) Manual	Phase 2	Osteoarthritis, Knee	12	Joint Stem	gklunvvell(otseoyajiw) = Single injection of AD-MSCs led to a significant improvement of the WOMAC score at 6 months. In the control group, there was no significant change in the WOMAC score at 6 months. mbnclqtyfp (tkiozhofjl ) View more	Positive	01 Jun 2019
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