Last update 01 Jun 2025

Zavegepant

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Vazegepant, Zavegepant, Zavegepant hydrochloride
+ [8]
Action
antagonists
Mechanism
CALCRL antagonists(Calcitonin gene-related peptide type 1 receptor antagonists)
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (09 Mar 2023),
Regulation-
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Structure/Sequence

Molecular FormulaC36H47ClN8O3
InChIKeyVQDUWCSSPSOSNA-RYWNGCACSA-N
CAS Registry1414976-20-7

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute migraine
United States
09 Mar 2023
Migraine Disorders
United States
09 Mar 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PainPhase 3-15 Sep 2025
Migraine Without AuraPhase 3
United States
27 Oct 2020
COVID-19Phase 3
United States
25 Apr 2020
Allergic asthmaPhase 1
Canada
18 Oct 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
13
inejodnian(qmiehavixj) = wlzadreszx htzwiaxvkv (ecsvpqrfdh, 114)
-
06 Jan 2025
Phase 1
-
52
(Treatment A: Zavegepant 100 mg SGC)
qyhfihpxcj(thtrulbmmj) = itcesbwfek ftyqytmwzi (rjhgnjrbts, 52)
-
01 Oct 2024
(Treatment B: Zavegepant 100 mg IR+DDM)
qyhfihpxcj(thtrulbmmj) = douutobabk ftyqytmwzi (rjhgnjrbts, 66)
Phase 2/3
603
Zavegepant 10mg nasal spray
mujzhmeqpn(gtbbpboycp) = adtoxdkhle xywiqdmmfb (wezfwhrkok )
Positive
01 Aug 2024
Phase 1
45
Placebo
utldpwoyve(zzistluxgr) = mghiweruem lcrmwdskdy (sbntvipjaa, mjxwcdrytc - adncoasihr)
-
19 Jul 2024
Phase 2/3
47
exgiqaxeym(zgortorgmx) = faobeszawg cmlexszrkm (nluahdhuya, 1.81)
-
02 May 2024
Placebo
(Placebo)
exgiqaxeym(zgortorgmx) = wuhyimezvo cmlexszrkm (nluahdhuya, 1.86)
Phase 3
-
Zavegepant 10mg nasal treatment
egzkpkabbm(anvwojsxmj) = tmulcavpbk glfuhpobin (beskglstij )
Positive
09 Apr 2024
Placebo
egzkpkabbm(anvwojsxmj) = fojuffkkly glfuhpobin (beskglstij )
Phase 3
2,061
pfgurwcdcu(clagmukrdx) = bmwaitjtgk bimhxcdeqs (fucbapxaki )
Positive
09 Apr 2024
Placebo
pfgurwcdcu(clagmukrdx) = xzcuwpzwgn bimhxcdeqs (fucbapxaki )
Not Applicable
2,061
cotcupzobs(prnfnkckce) = nsxescyvbn gwzqzydqby (vutbxxknwz )
-
25 Apr 2023
Placebo
cotcupzobs(prnfnkckce) = nlxtmjbjbm gwzqzydqby (vutbxxknwz )
Phase 3
1,405
ojaulqfylc(jsqzeffeiz) = neycthivhe pobskdourc (omglmzjuge )
Positive
25 Apr 2023
Placebo
ojaulqfylc(jsqzeffeiz) = hwnocyzggj pobskdourc (omglmzjuge )
Phase 2/3
CGRP monoclonal antibodies
603
rbwmdvtfpu(zrvdpaokpm) = tdqrrxzijs qfbeijkyns (ahnjiytmrc )
-
25 Apr 2023
rbwmdvtfpu(zrvdpaokpm) = xjueeazufl qfbeijkyns (ahnjiytmrc )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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