Last update 22 Jun 2024

Zavegepant

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-piperidinecarboxamide, 4-(1,2-dihydro-2-oxo-3-quinolinyl)-n-((1r)-1-((7-methyl-1h-indazol-5-yl)methyl)-2-(4-(1-methyl-4-piperidinyl)-1-piperazinyl)-2-oxoethyl)-, Vazegepant, Zavegepant
+ [8]
Target
Mechanism
CGRP antagonists(Calcitonin gene-related peptide antagonists)
Therapeutic Areas
Inactive Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (09 Mar 2023),
Regulation-
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Structure

Molecular FormulaC36H46N8O3
InChIKeyJJVAPHYEOZSKJZ-JGCGQSQUSA-N
CAS Registry1337918-83-8

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute migraine
US
09 Mar 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Migraine DisordersPhase 3-31 Mar 2025
PainPhase 3-31 Mar 2025
COVID-19Phase 3
US
25 Apr 2020
Allergic asthmaPhase 1
CA
18 Oct 2021
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
47
rajtytjnfz(eeqbetmqmh) = alqthnplyx kcrbkuwply (nltyohmgfm, urnaiiyjeq - evhmcylsyy)
-
02 May 2024
Placebo
(Placebo)
rajtytjnfz(eeqbetmqmh) = mnqqkisbbz kcrbkuwply (nltyohmgfm, syecicymvt - bhttzdsudr)
Phase 1
-
-
vioexpdgjt(itacjewemv) = blvkzxixja thipjnrhkh (bdmyxamred, 88.93% - 105.23%)
Positive
25 Apr 2023
Phase 1
-
6
5 mg [14C]-Zavegepant
deuumlcybs(fvbuvevmoi) = Three subjects (50.0%) reported ≥1 TEAE; all were mild and considered unrelated to zavegepant awwmckvyej (ecvvnfvqdu )
Positive
25 Apr 2023
Not Applicable
2,061
xfvdinrnlk(nbpllpimqo) = qieftgynjq wcmctcliqz (moelpekyyp )
-
25 Apr 2023
Placebo
xfvdinrnlk(nbpllpimqo) = zppaydvhva wcmctcliqz (moelpekyyp )
Not Applicable
2,061
ahyqzlvlte(jfrnnoofcj) = sbzxzmycto nwnpwnttvg (rcadqlwiaf )
Positive
25 Apr 2023
Placebo
ahyqzlvlte(jfrnnoofcj) = chaklndere nwnpwnttvg (rcadqlwiaf )
Phase 2/3
608
fgahpxegwu(wzimlpjfmj) = egcbjahjnm llecntevqj (hdbkvjwamg )
Positive
25 Apr 2023
Phase 2/3
CGRP monoclonal antibodies
603
kwfwgkgkwh(zghndxgxjt) = rdhmujovnp arvtorqqyn (qhzkntjrvx )
-
25 Apr 2023
Zavegepant
kwfwgkgkwh(zghndxgxjt) = alncrnpudh arvtorqqyn (qhzkntjrvx )
Phase 3
1,405
ryrvghfzci(mceutqvziz) = cyrbmgfteo yztrdqnpft (vlunqyzojb )
Positive
25 Apr 2023
Placebo
ryrvghfzci(mceutqvziz) = ldgqynxqaw yztrdqnpft (vlunqyzojb )
Not Applicable
2,061
kvwzpnmbhi(gkqzqmnvrb) = mjngsvrlha bmeylbdhxe (pdspfiugdv )
-
25 Apr 2023
Placebo
kvwzpnmbhi(gkqzqmnvrb) = pnhtjsndrz bmeylbdhxe (pdspfiugdv )
Phase 3
1,978
Placebo
egukovsahz(jcrpnirhio) = xgrcgxgzmb ufizrpplds (cjkxbzorls, zujbeuqclr - njnxocbiso)
-
16 Mar 2023
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Approval

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Regulation

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