A single-center, randomized, single-blind, controlled clinical trial of combined celecoxib with ketotifen fumarate to inhibit the recurrence of stiffness after release surgery for post-traumatic elbow stiffness

Start Date15 Dec 2023

Sponsor / Collaborator

Nanjing Drum Tower Hospital

NCT05815758

/ CompletedNot Applicable

A Multi-Center, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Study Evaluating the Safety and Pharmacokinetics of Brimonidine Tartrate 0.025%/Ketotifen Fumarate 0.035% Combination Ophthalmic Solution, Used Two Times Daily in Healthy Adult Subjects and in Pediatric Subjects With a History or Family History of Atopic Disease (Including Allergic Conjunctivitis)

To compare the safety and tolerability of brimonidine tartrate 0.025%/ketotifen fumarate 0.035% combination ophthalmic solution versus its vehicle in healthy adult subjects and in pediatric subjects.

Start Date20 Apr 2023

Sponsor / Collaborator

Bausch & Lomb, Inc.

NCT05616442

/ Unknown statusPhase 4IIT

Ketotifen in Non-Alcoholic Fatty Liver Disease Patients

The aim of this study is to investigate the safety and efficacy of using ketotifen in patients with NAFLD patients without cirrhosis

Start Date01 Dec 2022

Sponsor / Collaborator

Tanta University

100 Clinical Results associated with Ketotifen Fumarate

100 Translational Medicine associated with Ketotifen Fumarate

100 Patents (Medical) associated with Ketotifen Fumarate

2,425

Literatures (Medical) associated with Ketotifen Fumarate

01 Mar 2025·Luminescence

Sensitive Assessment of Ketotifen Levels in Tablets and Plasma Using a Photoinduced Electron Transfer (PET) Inhibition Spectrofluorimetric Approach

Article

Author: Alahmadi, Yaser ; Mostafa, Islam M. ; Alghamdi, Raed ; Mohamed, Abobakr A. ; Omar, Mahmoud A. ; Aljohani, Ahmed K. B.

ABSTRACTKetotifen (KTF) is a type of asthma medication that is taken along with other antiasthma medications and may reduce the frequency, severity, and duration of asthma symptoms or attacks in children. This research introduces a novel spectrofluorimetric method for detecting KTF in its tablets and human blood plasma samples (spiked with KTF). The detection mechanism is based on a photoinduced electron transfer (PET) inhibition spectrofluorimetric approach for the sensitive detection of KTF different samples. By protonating KTF with 2.0 M acetic acid, the PET process is effectively inhibited, leading to a significant enhancement in the fluorescence intensity of KTF at 392 nm. This method detects KTF at values from 50 to 500 ng mL−1. The technique offers excellent detection and quantification limits of 13.41 and 40.65 ng mL−1, respectively. The range of the obtained percentage recoveries of KTF for spiked plasma samples was found to be 98.40% ± 1.30%–99.82% ± 1.20%, demonstrating the method's precision and reliability in diverse biological matrices. Also, the approach successfully evaluated KTF content uniformity in tablets without interference.

01 Jan 2025·Journal of Ethnopharmacology

Exploring antiviral effect and mechanism of Jinye Baidu granules（JYBD）against influenza A virus through network pharmacology and in vitro and in vivo experiments

Article

Author: Liu, Menghua ; Zhang, Chunyu ; Jiang, Feng ; Liu, Shuwen ; Chen, Zhixuan ; Liang, Jinlong ; Mo, Qinxian ; Gao, Yinhuang ; Yang, Jie ; Yang, Sizu ; Luo, Siqi ; Ma, Jun ; Jiang, Linrui ; Li, Yinyan

ETHNOPHARMACOLOGICAL RELEVANCEJinye Baidu granules (JYBD) have been used to treat acute respiratory tract infections and demonstrated clinical efficacy for the treatment of emerging or epidemic respiratory viruses such as SARS-CoV-2 and influenza virus.AIM OF THE STUDYThis study is to investigate the antiviral effect of JYBD against influenza A viruses (IAV) in vitro and in vivo and elucidate its underlying mechanism.MATERIALS AND METHODSUltra-high-performance liquid chromatography connected with Orbitrap mass spectrometer (UHPLC-Orbitrap MS) was employed to describe the chemical profile of JYBD. The potential pathways and targets involved in JYBD against IAV infection were predicted by network pharmacology. The efficacy and mechanism of JYBD were validated through both in vivo and in vitro experiments. Moreover, combination therapy with JYBD and the classic anti-influenza drugs was also investigated.RESULTSA total of 126 compounds were identified by UHPLC-Orbitrap MS, of which 9 compounds were unambiguously confirmed with reference standards. JYBD could significantly inhibit the replication of multiple strains of IAV, especially oseltamivir-resistant strains. The results of qRT-PCR and WB demonstrated that JYBD could inhibit the excessive induction of pro-inflammatory cytokines induced by IAV infection and regulate inflammatory response through inhibiting JAK/STAT, NF-κB and MAPK pathways. Moreover, both JYBD monotherapy or in combination with oseltamivir could alleviate IAV-induced severe lung injury in mice.CONCLUSIONSJYBD could inhibit IAV replication and mitigate virus-induced excessive inflammatory response. Combinations of JYBD and neuraminidase inhibitors conferred synergistic suppression of IAV both in vitro and in vivo. It might provide a scientific basis for clinical applications of JYBD against influenza virus infected diseases.

01 Jan 2025·Journal of Allergy and Clinical Immunology

Omalizumab for mast cell disorders

Author: Akin, Cem

A review.The goals of treatment in MCD include avoidance of known triggers; treatment of the underlying pathol. when known; and pharmacotherapy targeting mast cell mediators such as with H1 and H2 histamine receptor blockers, leukotriene pathway modifiers, and mast cell stabilizers (which traditionally include cromolyn and ketotifen but may also be expanded to include calcineurin inhibitors and currently investigational agents such as Bruton tyrosine kinase [BTK] inhibitors).Well-designed prospective trials are needed to gain more information on the effect of omalizumab on mastocytosis and idiopathic anaphylaxis and determine the best approach to preventive therapy of anaphylaxis in these patient populations.Those subsets of patients with severe anaphylaxis or MCAS (with or without known mastocytosis) and an IgE-dependent trigger identified at diagnosis or during follow-up who experience breakthrough severe MCA events despite their best efforts at trigger avoidance and preventive antimediator therapy appear particularly well suited to benefit from omalizumab therapy.

News (Medical) associated with Ketotifen Fumarate

23 Sep 2024

·www.globenewswire.com

AB Science provides an update on the development of masitinib in progressive forms of multiple sclerosis post ECTRIMS 2024

PRESS RELEASE AB SCIENCE PROVIDES AN UPDATE ON THE DEVELOPMENT OF MASITINIB IN PROGRESSIVE FORMS OF MULTIPLE SCLEROSIS POST ECTRIMS 2024 Paris, 23 September 2024, 5.45pm CET AB Science SA (Euronext - FR0010557264 - AB) today provides an update on the development of masitinib in progressive forms of multiple sclerosis (MS), following the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) 2024 conference. The development of masitinib in progressive forms of multiple sclerosis is based on the MAXIMS study (AB20009), a randomized, double-blind, phase 3 study of masitinib 4.5 mg/kg/day in patients with primary progressive multiple sclerosis (PPMS) and non-active secondary progressive multiple sclerosis (nSPMS). The study enrolls patients with Expanded Disability Status Scale (EDSS) score between 3.0 to 6.0, progression of disease for the last 2 years and absence of T1 Gadolinium-enhancing brain lesions. The primary endpoint of the study is the effect of masitinib on time to confirmed disability progression. The recent results of tolebrutinib in non-active secondary progressive MS presented at the ECTRIMS 2024 conference, reinforce the scientific hypothesis that targeting microglia in nSPMS is a valid approach. Tolebrutinib belongs to a class of drugs that target microglia through an enzymatic target called BTK (Bruton Tyrosine Kinase). Masitinib also targets microglia but through a different enzymatic target called M-CSFR1 (Macrophage Colony Stimulating Factor Receptor-1) and generated positive results in phase 2B (AB07002) [1], which are consistent with tolebrutinib data. EDSS progression confirmed at 3 months was reduced by 37% with masitinib in study AB07002 and by 23% with tolebrutinib in the Hercules study (although the reduction in study AB07002 did not reach the conventional 5% p-value since the study was not powered to detect a significant effect in this secondary endpoint, having 300 patients in the masitinib 4.5 or placebo arms as compared with 1100 patients in the Hercules trial).EDSS progression confirmed at 6 months was reduced by 32% with masitinib and by 31% with tolebrutinib. Importantly, Masitinib significantly improved manual dexterity measured by 9-hole Peg test, in study AB07002 (-4,28 ; p=0,0388).Masitinib has shown the ability to decrease serum neurofilament light chain (NfL) concentration in an animal model of MS, and by extension therefore, possibly neuronal damage [2].Masitinib not only targets microglia but also mast cells, which play a crucial role in progressive MS and in the experimental autoimmune encephalomyelitis (EAE) model of MS, as shown by numerous publications [3-13]. Masitinib benefits from a large safety database with long-term exposure across various indications. In non-oncology indications, around 2,200 patients have received at least one dose of masitinib, more than 1,300 patients have received masitinib for more than six months and close to 1,000 patients have received masitinib for more than one year. BTK safety profiles shows increase in liver injury, hypertension and infections which seem to be a class effect, leaving room for alternative drugs. As a conclusion, masitinib represents a potential credible alternative to BTK inhibitors in the development of new drugs both in primary and non-active secondary progressive MS. Professor Patrick Vermersch, MD, principal investigator of the MAXIMS study, Director of the Doctoral School Biology-Health of the University of Lille, commented: “Tolebrutinib data are important and pave the way to a series of new drugs in progressive forms of MS. Along with BTK inhibitors, masitinib represents a serious potential alternative in the two forms of progressive MS, primary and non-active secondary progressive MS, which remain the two unmet medical needs. The role of mast cells is not to be neglected in MS”. This new development fits well the strategy currently implemented for masitinib, as it further strengthens the scientific rationale for the development of masitinib in progressive forms of MS as well as the plausibility of the results generated with phase 2B/3 study AB07002. About the results of the previous phase 2B/3 study AB07002Study AB07002 met its primary analysis endpoint, demonstrating a statistically significant reduction in cumulative change on EDSS with masitinib 4.5 mg/kg/day (p=0.0256) [1]. This treatment-effect was consistent for PPMS and nSPMS. In addition, masitinib significantly reduced the risk of first disability progression by 42% and the risk of confirmed (3 months) disability progression by 37%. Masitinib also significantly reduced the risk of reaching an EDSS score of 7.0, corresponding to disability severe enough that the patient is restricted to a wheelchair (p=0.0093). The product's safety was consistent with the known risk profile of masitinib, with no elevated risk of infection. [References] [1] Vermersch P, Brieva-Ruiz L, Fox RJ, et al. Efficacy and Safety of Masitinib in Progressive Forms of Multiple Sclerosis: A Randomized, Phase 3, Clinical Trial. Neurol Neuroimmunol Neuroinflamm. 2022 Feb 21;9(3):e1148. [2] Hermine O, Vermersch P, et al. Masitinib limits neuronal damage, as measured by serum neurofilament light chain concentration, in a model of neuroimmune-driven neurodegenerative disease. Preprint. bioRxiv 2024.03.07.583695; doi: https://doi.org/10.1101/2024.03.07.583695 [3] Sandhu JK, Kulka M. Decoding Mast Cell-Microglia Communication in Neurodegenerative Diseases. Int J Mol Sci. 2021 Jan 22;22(3):1093. [4] Pinke KH, et al. Should mast cells be considered therapeutic targets in multiple sclerosis? Neural Regen Res. 2020 Nov;15(11):1995-2007. [5] Pinke KH, et al. Calming Down Mast Cells with Ketotifen: A Potential Strategy for Multiple Sclerosis Therapy? Neurotherapeutics. 2020 Jan;17(1):218-234. [6] Brown MA, Weinberg RB. Mast Cells and Innate Lymphoid Cells: Underappreciated Players in CNS Autoimmune Demyelinating Disease. Front Immunol. 2018;9:514. [7] Skaper SD, Facci L, Zusso M, Giusti P. An Inflammation-Centric View of Neurological Disease: Beyond the Neuron Front Cell Neurosci. 2018;12:72. [8] Hendriksen E, et al. Mast cells in neuroinflammation and brain disorders Neurosci Biobehav Rev. 2017;79:119-133. [9] Elieh-Ali-Komi D, Cao Y. Role of Mast Cells in the Pathogenesis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Clin Rev Allergy Immunol. 2017;52(3):436-445. [10] Conti P, Kempuraj D. Important role of mast cells in multiple sclerosis. Mult Scler Relat Disord. 2016;5:77-80. [11] Skaper SD, Facci L, Giusti P. Mast cells, glia and neuroinflammation: partners in crime?. Immunology. 2014;141(3):314-327. [12] Skaper SD, et al. Microglia and mast cells: two tracks on the road to neuroinflammation. FASEB J. 2012;26(8):3103-3117. [13] Zappulla JP, Arock M, Mars LT, Liblau RS. Mast cells: new targets for multiple sclerosis therapy?. J Neuroimmunol. 2002;131(1-2):5-20. About AB ScienceFounded in 2001, AB Science is a pharmaceutical company specializing in the research, development and commercialization of protein kinase inhibitors (PKIs), a class of targeted proteins whose action are key in signaling pathways within cells. Our programs target only diseases with high unmet medical needs, often lethal with short term survival or rare or refractory to previous line of treatment. AB Science has developed a proprietary portfolio of molecules and the Company’s lead compound, masitinib, has already been registered for veterinary medicine and is developed in human medicine in oncology, neurological diseases, inflammatory diseases and viral diseases. The company is headquartered in Paris, France, and listed on Euronext Paris (ticker: AB). Further information is available on AB Science’s website: www.ab-science.com. Forward-looking Statements - AB ScienceThis press release contains forward-looking statements. These statements are not historical facts. These statements include projections and estimates as well as the assumptions on which they are based, statements based on projects, objectives, intentions and expectations regarding financial results, events, operations, future services, product development and their potential or future performance. These forward-looking statements can often be identified by the words "expect", "anticipate", "believe", "intend", "estimate" or "plan" as well as other similar terms. While AB Science believes these forward-looking statements are reasonable, investors are cautioned that these forward-looking statements are subject to numerous risks and uncertainties that are difficult to predict and generally beyond the control of AB Science and which may imply that results and actual events significantly differ from those expressed, induced or anticipated in the forward-looking information and statements. These risks and uncertainties include the uncertainties related to product development of the Company which may not be successful or to the marketing authorizations granted by competent authorities or, more generally, any factors that may affect marketing capacity of the products developed by AB Science, as well as those developed or identified in the public documents published by AB Science. AB Science disclaims any obligation or undertaking to update the forward-looking information and statements, subject to the applicable regulations, in particular articles 223-1 et seq. of the AMF General Regulations. For additional information, please contact: AB ScienceFinancial Communication & Media Relations investors@ab-science.com Attachment CP UPDATE ECTRIMS 2024. VEng VF

Clinical ResultPhase 3Phase 2

12 Sep 2024

·www.inotekcorp.com

Benefits and Safety of Preservative-Free Allergy Eye Drops – A Comprehensive Guide

Preservative-free allergy eye drops offer a range of advantages for individuals seeking relief from allergic reactions affecting their eyes. Here are some of the key benefits: Gentle on the eyes: Preservative-free eye drops are formulated without harsh chemicals that can cause irritation or discomfort. Reduced risk of allergic reactions: Some individuals may be sensitive to preservatives commonly found in eye drops, making preservative-free options a safer choice. Long-term use: Preservative-free eye drops are suitable for prolonged use, allowing individuals to manage their allergy symptoms effectively without concerns about preservative buildup. Less risk of eye dryness: Preservatives in eye drops can sometimes contribute to dryness, particularly with frequent use. Preservative-free options help maintain eye moisture levels. Effective symptom relief: These eye drops can provide quick and lasting relief from itching, redness, and irritation caused by allergies. According to a study published in the New England Journal of Medicine, preservative-free eye drops were found to be highly effective in managing allergy-related eye symptoms, with a significant improvement in overall comfort reported by participants. Furthermore, a survey conducted by the American Academy of Ophthalmology revealed that 9 out of 10 ophthalmologists recommend preservative-free eye drops for patients with allergy-related eye issues due to their gentler formulation and enhanced safety profile compared to preserved alternatives. When it comes to managing allergy symptoms, finding relief without experiencing discomfort is key. Allergy eye drops that don’t burn offer a gentle and comfortable application process, making them ideal for individuals looking for soothing relief. Unlike traditional eye drops that may cause stinging or burning sensations upon administration, these gentle formulations are designed to provide relief without irritation. Soothing Relief: These eye drops offer a soothing sensation upon application, helping to alleviate allergy symptoms without causing additional discomfort. Comfortable Administration: The gentle formulation ensures that users can apply the drops easily and comfortably, even multiple times a day if needed. No Irritation: By using allergy eye drops that don’t burn, individuals can effectively manage their symptoms without the risk of experiencing irritation or stinging in the eyes. According to a study published in the American Journal of Ophthalmology, allergy eye drops that don’t burn have been shown to be well-tolerated by patients, with a high level of satisfaction regarding their comfort and effectiveness. When selecting allergy eye drops that don’t burn, it’s essential to look for preservative-free options that are specifically formulated for sensitive eyes. Brands like Alaway, Zaditor, and Bausch + Lomb offer gentle formulations that provide effective relief without causing discomfort. By opting for allergy eye drops that don’t burn, individuals can manage their allergy symptoms with ease and comfort, ensuring that their eyes are protected and soothed throughout the allergy season. $35.66 $65.17 $29.00 $64.80 When it comes to treating allergies in young children, safety is of utmost importance. Allergy eye drops can be an effective solution for alleviating symptoms such as itching, redness, and swelling in the eyes. However, many parents are understandably concerned about using products that may not be suitable for their little ones. It’s crucial to choose allergy eye drops that are specifically formulated for children and are gentle on their delicate eyes. Some allergy eye drops contain preservatives that can cause irritation or adverse reactions in young children. That’s why opting for preservative-free allergy eye drops is a wise choice when treating allergies in a 4-year-old. According to the American Academy of Ophthalmology, preservatives in eye drops can be harsh on the eyes, especially for children whose eyes are still developing. The use of preservative-free allergy eye drops ensures that your child’s eyes are not exposed to potentially harmful chemicals, providing safe and effective relief from allergy symptoms. Dr. Sarah Johnson, a pediatric ophthalmologist, advises, “When choosing allergy eye drops for a 4-year-old, it’s essential to opt for preservative-free formulations. These gentle eye drops are less likely to cause irritation and are suitable for use in children.” Studies have shown that preservative-free allergy eye drops are not only safe but also effective in relieving allergy symptoms in children. A clinical trial conducted by the National Institutes of Health found that children who used preservative-free eye drops experienced significant improvement in their allergy symptoms without any adverse effects. When treating allergies in young children, always consult with a pediatrician or eye care specialist before using any eye drops. They can provide guidance on the appropriate dosage and frequency of application to ensure your child’s safety and comfort. In conclusion, choosing allergy eye drops that are free of preservatives is a safe and gentle option for treating allergies in 4-year-olds. By opting for preservative-free formulations, you can provide your child with effective relief from allergy symptoms without compromising their eye health. When it comes to managing allergy symptoms while breastfeeding, it’s important for nursing mothers to consider the safety of the products they use. Allergy eye drops that are free from preservatives offer a gentle solution that is suitable for breastfeeding women. Preservative-free allergy eye drops are ideal for mothers who want to avoid exposing their baby to potentially harmful substances. The absence of preservatives reduces the risk of irritation and sensitivity, making them a safe choice for nursing mothers. According to the American Academy of Pediatrics, many medications are compatible with breastfeeding, including certain types of eye drops. Preservative-free allergy eye drops are considered safe for use while breastfeeding, providing relief from eye allergy symptoms without posing a risk to the nursing infant. It’s always advisable for breastfeeding mothers to consult with their healthcare provider before using any medication, including eye drops. However, the gentle formulation of preservative-free allergy eye drops makes them a favorable option for nursing mothers looking for symptom relief without compromising their baby’s health. For more information on medications and their compatibility with breastfeeding, you can refer to reputable sources such as the American Academy of Pediatrics and the Centers for Disease Control and Prevention. For individuals who wear contact lenses, finding the right allergy eye drops that are compatible with their lenses is crucial for maintaining eye health and comfort. Many traditional allergy eye drops contain preservatives that can interact with contact lenses and cause irritation or discomfort. Fortunately, there are preservative-free allergy eye drops available on the market that are safe to use with contact lenses. These gentle formulations provide relief from allergy symptoms without compromising the integrity of your contact lenses. Some popular preservative-free allergy eye drops that are compatible with contact lenses include: Bausch + Lomb Alaway Antihistamine Eye Drops: Clinically tested and proven to relieve itching and redness caused by allergies, these eye drops are suitable for contact lens wearers. Oasis Tears Plus Preservative-Free Lubricant Eye Drops: Ideal for individuals with dry eye symptoms aggravated by allergies, these eye drops are safe for use with contact lenses. Blink Contacts Lubricating Eye Drops: Specifically designed for contact lens wearers, these drops provide immediate hydration and comfort without the need to remove your lenses. According to a survey conducted by the American Optometric Association, 8 out of 10 contact lens wearers experience eye discomfort at some point, with allergies being a common trigger. Utilizing preservative-free allergy eye drops that are compatible with contact lenses can help alleviate symptoms and promote clearer, more comfortable vision. For more information on eye drop compatibility with contact lenses, consult with your eye care provider or optometrist for personalized recommendations tailored to your specific needs. When it comes to managing allergy symptoms such as itching, redness, swelling, and watering of the eyes, choosing the right eye drops is crucial. Preservative-free allergy eye drops are highly effective in providing relief without causing irritation. This gentle formulation is suitable for individuals with sensitive eyes and can be used multiple times a day without concern. One key benefit of preservative-free eye drops is that they eliminate the risk of allergic reactions to preservatives commonly found in other eye drops. By opting for preservative-free options, users can experience immediate relief from allergy symptoms without the added discomfort of burning or stinging that some eye drops can cause. A study published in the Journal of Allergy and Clinical Immunology tested the effectiveness of preservative-free allergy eye drops on a group of allergy sufferers and found a significant reduction in symptoms such as itching and redness within minutes of application. The participants reported improved comfort and overall satisfaction with the product. According to a survey conducted by the American Academy of Allergy, Asthma, and Immunology, 9 out of 10 allergy sufferers experienced relief from using preservative-free eye drops, highlighting the efficacy of this treatment option. The ease of use and rapid onset of action make preservative-free allergy eye drops a preferred choice for many individuals seeking quick and long-lasting relief. In summary, preservative-free allergy eye drops are a safe and effective solution for managing allergy symptoms without the risk of irritation or allergic reactions. By choosing this gentle formulation, users can experience prompt relief and improved comfort, making it a top choice for those dealing with allergic conjunctivitis and other eye-related allergies. When it comes to selecting preservative-free allergy eye drops, there are several factors to consider to ensure you find the right product that meets your needs. Here are some recommendations to help you make an informed decision: Before starting any new eye drop regimen, it is essential to consult with an eye care professional, such as an ophthalmologist or optometrist. They can provide you with personalized recommendations based on your specific allergy symptoms and overall eye health. Check the ingredients list of the allergy eye drops to ensure they do not contain any substances you may be allergic to. Look for products that are free of preservatives, artificial dyes, and other potential irritants. Choose allergy eye drops that are specifically formulated to provide relief from your allergy symptoms, such as itching, redness, and watering. Look for products that are clinically proven to be effective in alleviating these common allergic reactions. Research the reputation of the brand that manufactures the allergy eye drops. Look for reviews from other users to get a sense of the product’s effectiveness and any potential side effects. Trusted brands with a history of producing high-quality eye care products are typically a safe choice. Compare prices of different preservative-free allergy eye drops to find a product that fits within your budget. Keep in mind that higher-priced products may not always indicate better quality, so look for a balance between affordability and effectiveness. Consider the packaging and application method of the eye drops. Some products come in convenient single-dose vials, while others may have a multi-dose bottle. Choose a format that is easy for you to use and fits your lifestyle. Ensure that the preservative-free allergy eye drops you choose are readily available in pharmacies or online retailers. Opt for a product that you can easily replenish when needed to maintain consistent symptom relief. By following these recommendations, you can select the right preservative-free allergy eye drops that are safe, effective, and suitable for your unique needs. Remember to always follow the instructions provided by the manufacturer and seek medical advice if you experience any adverse reactions.

Clinical Result

12 Sep 2024

·www.inotekcorp.com

Rhodo Eye Drops – Benefits, Usage, Side Effects, and Reviews

Rhodo eye drops are a popular ophthalmic solution that is used to provide relief from various eye conditions. These eye drops contain a unique formula that combines several key ingredients such as Rhododenol, hyaluronic acid, and vitamin B12. Rhododenol is a potent antioxidant that helps protect the eyes from oxidative stress and UV damage. Hyaluronic acid provides moisturizing and lubricating properties, which can help alleviate dryness and irritation in the eyes. Vitamin B12 is essential for maintaining healthy nerve function and may support overall eye health. These eye drops are designed to be gentle yet effective, making them suitable for individuals with sensitive eyes. They can be used to relieve symptoms of dryness, redness, itchiness, and fatigue, providing quick and soothing relief. Overall, Rhodo eye drops are a versatile and reliable solution for maintaining eye health and comfort on a daily basis. Using Rhodo eye drops can offer various benefits for your eye health and overall well-being. Here are some key advantages of incorporating Rhodo eye drops into your eye care routine: Relief from dry eyes: Rhodo eye drops contain lubricants that can help provide relief from dry eyes, which can be caused by factors such as digital eye strain, environmental conditions, or underlying health issues. Reduces eye irritation: The soothing properties of Rhodo eye drops can help reduce eye irritation, itchiness, and discomfort, providing a refreshing sensation to tired eyes. Improves eye hydration: By hydrating the eyes, Rhodo eye drops can help maintain the moisture balance in the eyes, preventing dryness and promoting overall eye health. Enhances clarity and vision: Regular use of Rhodo eye drops can help improve the clarity of your vision by reducing blurry vision and enhancing focus, especially during prolonged screen time or activities that strain the eyes. With these benefits, Rhodo eye drops can be a valuable addition to your eye care regimen, offering comfort, hydration, and support for optimal eye health. $35.66 $65.17 $29.00 $64.80 When using Rhodo eye drops, it is essential to follow the instructions provided on the packaging or by your healthcare provider. Here are some tips to help you use Rhodo eye drops effectively: Before using the eye drops, make sure to wash your hands thoroughly with soap and water. This will help prevent any contamination of the drops. Tilt your head back slightly and pull down your lower eyelid to create a small pocket. This will make it easier to administer the drops into your eye. Squeeze the bottle gently to release one drop into the pocket you created. Be careful not to touch your eye with the tip of the bottle to avoid contamination. After administering the drop, close your eyes gently for a few seconds to allow the medication to spread evenly over the surface of your eye. If your healthcare provider has instructed you to use more than one drop, wait at least five minutes before administering the next drop to allow the first one to be absorbed. Remember to store Rhodo eye drops in a cool, dry place, away from direct sunlight. Do not share your eye drops with others, as this can lead to infection or contamination. When considering eye drops for various eye conditions, it’s important to compare different products to choose the one that best suits your needs. Rhodo eye drops are a popular choice, but how do they compare to other similar products on the market? Let’s take a closer look at how Rhodo eye drops stack up against some competitors: While Visine is known for its redness relief properties, Zaditor targets allergies specifically. Rhodo eye drops, on the other hand, focus on providing relief for dry, red, and irritated eyes with the help of rhodiola extract and hyaluronic acid. The price point for Rhodo eye drops falls in between Visine and Zaditor, making it a budget-friendly option for those looking for holistic eye care. When it comes to user reviews, Rhodo eye drops have received positive feedback for their effectiveness in relieving eye discomfort without harsh chemicals. Users appreciate the natural ingredients and gentle approach to eye care provided by Rhodo eye drops. Considering the active ingredients, uses, and price point, Rhodo eye drops offer a unique alternative to other eye drops on the market, catering to individuals seeking natural eye care solutions. While Rhodo eye drops can provide relief for various eye conditions, it is important to be aware of potential side effects and take necessary precautions when using this product. Some users may experience mild burning or stinging sensation upon instillation of Rhodo eye drops. This discomfort is usually temporary and should subside quickly. In rare cases, individuals may develop allergic reactions to the ingredients in Rhodo eye drops. If you experience any signs of an allergic reaction such as itching, redness, swelling, or difficulty breathing, discontinue use immediately and seek medical attention. Long-term use of Rhodo eye drops may lead to rebound redness or dependence on the product. It is important to use Rhodo eye drops as directed and consult a healthcare professional if you have concerns about prolonged use. Do not touch the tip of the Rhodo eye drop container to avoid contamination. Avoid sharing your Rhodo eye drops with others to prevent the spread of infection. If you are pregnant or nursing , consult your healthcare provider before using Rhodo eye drops to ensure they are safe for you and your baby. It is essential to follow the instructions provided on the product packaging and consult a healthcare professional if you have any concerns about using Rhodo eye drops. By taking the necessary precautions and being aware of potential side effects, you can ensure a safe and effective experience with this eye drop solution. To provide a comprehensive overview of Rhodo eye drops, it’s essential to consider the experiences and feedback shared by actual users. Here are some testimonials and reviews from individuals who have used Rhodo eye drops: “I’ve been suffering from dry eyes for years, and I’ve tried numerous eye drops without much success. However, after using Rhodo eye drops for a few weeks, I noticed a significant improvement in the moisture level of my eyes. The drops are easy to use and have become a part of my daily routine.” “As someone who spends hours in front of a screen due to work, I often experience eye strain and discomfort. Rhodo eye drops have been a game-changer for me. They provide instant relief and soothing hydration to my eyes. I highly recommend them to anyone dealing with similar issues.” “I have sensitive eyes and have struggled to find eye drops that don’t irritate them further. Rhodo eye drops were recommended to me by a friend, and I’m so glad I tried them. Not only are they gentle on my eyes, but they also effectively alleviate redness and dryness. I won’t be switching to any other brand.” These testimonials highlight the positive experiences of individuals who have incorporated Rhodo eye drops into their eye care routines. The diverse range of users, from those with dry eyes to individuals dealing with eye strain, showcases the versatility and effectiveness of Rhodo eye drops in addressing various eye concerns. If you are interested in purchasing Rhodo eye drops, you can find them at various online and offline retailers. It is recommended to buy Rhodo eye drops from reputable sources to ensure the quality and authenticity of the product. Here are some of the popular online platforms where you can purchase Rhodo eye drops: Amazon Walgreens CVS Pharmacy The pricing of Rhodo eye drops may vary depending on the retailer and any ongoing promotions or discounts. It is advisable to compare prices across different platforms to find the best deal. On average, a bottle of Rhodo eye drops typically ranges from $10 to $20. Before making a purchase, read customer reviews and testimonials to get an idea of the product’s effectiveness and user satisfaction. Additionally, check for any offers or bundle deals that may be available to save on your purchase of Rhodo eye drops.

100 Deals associated with Ketotifen Fumarate

External Link

KEGG	Wiki	ATC	Drug Bank
D01332	Ketotifen Fumarate	S01GX08 R06AX17	DB00920

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Seasonal allergic conjunctivitis	Sweden	Laboratoires Théa SAS	31 Oct 2000
Dermatitis	Japan	Sun Pharma Japan Ltd.	30 Apr 1986
Eczema	Japan	Sun Pharma Japan Ltd.	30 Apr 1986
Pruritus	Japan	Sun Pharma Japan Ltd.	30 Apr 1986
Urticaria	Japan	Sun Pharma Japan Ltd.	30 Apr 1986
Asthma	Switzerland	Novartis Pharma AG	03 May 1979
Chronic Urticaria	Switzerland	Sandoz International GmbH	03 May 1979
Conjunctivitis, Allergic	Switzerland	Sandoz International GmbH	03 May 1979
Dermatitis, Atopic	Switzerland	Sandoz International GmbH	03 May 1979
Rhinitis, Allergic	Switzerland	Sandoz International GmbH	03 May 1979

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Seasonal allergic conjunctivitis	Phase 3	United States	Bausch & Lomb, Inc.	18 Nov 2022

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05579730 (CTgov)	Phase 3	Conjunctivitis, Allergic	188	Brimonidine tartrate 0.025%/ketotifen fumarate 0.035% (Combination)	dmrhdwmiev(jipjhiorfb) = aehotodvem manryqytmn (pofhbeuygf, vnchjhhldz - yftbwjygom) View more	-	14 Feb 2025
				Ketotifen Fumarate 0.035% (Ketotifen Fumarate)	dmrhdwmiev(jipjhiorfb) = csjoogjpzm manryqytmn (pofhbeuygf, otrqkvrldv - hezxbgdiiy) View more
UEGW2018	Not Applicable	Mast Cell Activation Disorders	-	Ketotifen	uqmgraywtb(tnqativqxq) = lnqqmgrvxw aahdstyslw (wvdbfgcxyg )	-	01 Oct 2018
				Fexofenadine	uqmgraywtb(tnqativqxq) = jvtnaewwzb aahdstyslw (wvdbfgcxyg )
AAAAI2012	Not Applicable	Peanut Hypersensitivity eosinophilia	6	Ketotifen	dgydzvywoj(zgxrkzrphf) = 3 anaphylactic reactions occurred: day-1 placebo patient at 50mg dose (gastrointestinal, cutaneous); day-5 treatment patient at 50mg dose, occurred post exercise, (gastrointestinal, cutaneous, respiratory); day-6 placebo patient at 12mg dose, associated with fever, (gastrointestinal, cutaneous, respiratory), epinephrine was given and patient withdrew from study ebkgddzsqw (psfwvbvblk ) View more	Positive	01 Feb 2012
				Placebo
ARVO2004	Not Applicable	Acute conjunctivitis	99	Epinastine HCl 0.05%	(ppbccoxylo) = Three (5.9%) epinastine patients and 7 (14.6%) ketotifen patients experienced adverse events. Treatment-related sleep disorder was reported for 2 ketotifen-treated patients, but was not found in epinastine-treated patients. mihapwdhup (hxjhounksm )	-	01 May 2004
				Ketotifen
ARVO2003	Not Applicable	Conjunctivitis, Allergic	92	Ketotifen fumarate 0.025%	ksxkyapzyb(tuhmtvdaok) = klxayhlccf gmbsysaypg (abkugzfchj )	-	01 May 2003
				Olopatadine HCl 0.1%	ksxkyapzyb(tuhmtvdaok) = emmxmqrncm gmbsysaypg (abkugzfchj )
ARVO2003	Not Applicable	Conjunctivitis, Allergic HLA-DR+ \| CD29+ \| eotaxin+	19	Ketotifen fumarate 0,05%	(eohszbviim) = tdznikvdes azkywgnbax (fyuawyolpz ) View more	Positive	01 May 2003

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis