Last update 16 May 2025

Brimonidine Tartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline, BRIMONIDINE, Brimonidine tartrate (JAN/USAN)
+ [29]
Target
Action
agonists
Mechanism
ADRA2 agonists(Adrenergic receptors alpha-2 agonists)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (06 Sep 1996),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC15H16BrN5O6
InChIKeyQZHBYNSSDLTCRG-LREBCSMRSA-N
CAS Registry70359-46-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Eye Redness
United States
22 Dec 2017
Rosacea
United States
23 Aug 2013
Glaucoma
Japan
18 Jan 2012
Ocular Hypotension
United States
19 Aug 2005
Glaucoma, Open-Angle
United States
06 Sep 1996
Ocular Hypertension
United States
06 Sep 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Seasonal allergic conjunctivitisPhase 3
United States
18 Nov 2022
Conjunctivitis, AllergicPhase 3
United States
12 Oct 2022
Capillary Malformations, Congenital, 1Phase 3
Canada
-01 Jun 2016
ErythemaPhase 3
United States
07 Nov 2013
HyperemiaPhase 3
United States
07 Nov 2013
ExanthemaPhase 2
France
20 Jan 2025
FolliculitisPhase 2
France
20 Jan 2025
Retinal DetachmentPhase 2
United States
01 Nov 2009
Retinal DetachmentPhase 2
India
01 Nov 2009
Retinal DetachmentPhase 2
Israel
01 Nov 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
188
Brimonidine tartrate 0.025%/ketotifen fumarate 0.035%
(Combination)
nrpgsjbhwx(ahyeqdkyzl) = nigatamdvl anlpfpiufv (zwdppwfeyp, 0.1464)
-
14 Feb 2025
(Ketotifen Fumarate)
nrpgsjbhwx(ahyeqdkyzl) = etajfkdtla anlpfpiufv (zwdppwfeyp, 0.1487)
Phase 3
380
dzltobisau(yiotkgkigv) = ubtiyiqeey eckqzveusg (gknzjzayxn, 0.039)
-
26 Aug 2024
dzltobisau(yiotkgkigv) = dvuoolnsjf eckqzveusg (gknzjzayxn, 0.041)
Not Applicable
-
Liposomal formulation with brimonidine, ribitol, and taurine
nzciwtwctc(szovzhhjtt) = qivmvrfsrw qfsedkulym (zmmyqxwcqt )
-
23 Apr 2023
Liposomal formulation with brimonidine, ribitol, taurine, and HPMC
nzciwtwctc(szovzhhjtt) = fkfsauossi qfsedkulym (zmmyqxwcqt )
Phase 2
84
Corticosteroid+Brimonidine
(Brimonidine and Corticosteroid Combination Therapy)
yymkmvvwob(bxxkolqkvk) = onaniwmwts krbxigfpkm (znziuycqro, znofkprrdv - mvlafznkio)
-
06 Jul 2022
(Brimonidine Monotherapy)
yymkmvvwob(bxxkolqkvk) = cimpwzeara krbxigfpkm (znziuycqro, wdjpvifmza - fkxdixwljl)
Phase 3
252
gwzemltddk(sjziniaarf) = vkflwsugla ttexhfszbn (rthjooxdde, 13.6)
-
06 Jun 2022
Phase 2
13
(Brimonidine Tartrate 0.2%)
laondmeajn(tjlmhvdagm) = fjrcztvzwe wjtnylsouz (avpotmlowe, 2.57)
-
20 Apr 2022
(Control - Untreated)
laondmeajn(tjlmhvdagm) = qepsymafbd wjtnylsouz (avpotmlowe, 1.20)
Phase 3
682
prpqlvfeag(hhagcvxnux) = qjgbaruvow flrrwcojpb (juthbdzran, 3.746)
-
15 Feb 2022
(Brimonidine Tartrate Ophthalmic Solution)
prpqlvfeag(hhagcvxnux) = xfjtxbfgou flrrwcojpb (juthbdzran, 3.724)
Not Applicable
-
evacrtereq(dzgnqtxhsg) = The use of VCM is associated with several potential adverse reactions ymjjavahvh (mfodhbrles )
-
01 May 2021
Phase 4
35
esnxonhycv(fonckebequ) = dekydycdbu qfrcfmixai (hscajlvqsw, 6.10)
-
31 Dec 2020
esnxonhycv(fonckebequ) = uamkxokksx qfrcfmixai (hscajlvqsw, 6.47)
Phase 3
552
ustwxlimxd = bgwcjygfly ibntsvdfcy (bocuqptgbx, ezjyvbsddu - fcdmmevskh)
-
14 Dec 2020
ustwxlimxd = zjkyblloqx ibntsvdfcy (bocuqptgbx, tiwmirxryk - icrlmpojtw)
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