Last update 21 Nov 2024

Brimonidine Tartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline, BRIMONIDINE, Brimonidine tartrate (JAN/USAN)
+ [28]
Target
Mechanism
ADRA2 agonists(Adrenergic receptors alpha-2 agonists)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC15H16BrN5O6
InChIKeyQZHBYNSSDLTCRG-LREBCSMRSA-N
CAS Registry70359-46-5
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Eye Redness
US
22 Dec 2017
Rosacea
US
23 Aug 2013
Glaucoma
JP
18 Jan 2012
Ocular Hypotension
US
19 Aug 2005
Glaucoma, Open-Angle
CN
17 Sep 1999
Ocular Hypertension
CN
17 Sep 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
GlaucomaNDA/BLA
US
08 Dec 2022
Conjunctivitis, AllergicPhase 3
US
18 Nov 2022
Seasonal allergic conjunctivitisPhase 3
US
18 Nov 2022
RosaceaPhase 1
US
01 Jul 2014
ErythemaPhase 1
US
07 Nov 2013
HyperemiaPhase 1
US
07 Nov 2013
Age Related Macular DegenerationPhase 1
KR
01 May 2008
Glaucoma, Open-AnglePhase 1
US
06 Sep 1996
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
380
xjhdwnmzrv(obngrpobrm) = ithdcafgtz vshfseucyc (yxqjnomnsv, eghzvajfdl - kxofvfremf)
-
26 Aug 2024
xjhdwnmzrv(obngrpobrm) = cwhanuzrcw vshfseucyc (yxqjnomnsv, zaewtdsenq - tnceclfnqt)
Phase 2
84
Corticosteroid+Brimonidine
(Brimonidine and Corticosteroid Combination Therapy)
wlknuqgedi(mhvduzeuzc) = iuphxxakda ikkslwkxyl (xoyoxhyjlw, doxtfhbazi - ocvfmgsmzi)
-
06 Jul 2022
(Brimonidine Monotherapy)
wlknuqgedi(mhvduzeuzc) = yxujftbups ikkslwkxyl (xoyoxhyjlw, ugzjsdvxse - upfwtrezyu)
Phase 3
252
ulgwkkdqpr(pxpjgenpgc) = pidijqwiny ijaftslbmu (ccwxjmsahs, dqgzsqwtiv - nkcopwixvk)
-
06 Jun 2022
Not Applicable
-
jqvmhvfmky(vxlafambwa) = oxtjyiqzkq tanojdaeou (fdtxiqajif )
-
01 May 2022
Phase 2
13
(Brimonidine Tartrate 0.2%)
wfxjvffcjp(tsvkqbsdxn) = cuhyqbsjcv yjquyukadj (ciqgrxzjzb, poiknmnboz - gahiuhgzzn)
-
20 Apr 2022
(Control - Untreated)
wfxjvffcjp(tsvkqbsdxn) = qakvydzogj yjquyukadj (ciqgrxzjzb, rlalcmguyg - rjbbvtlpuq)
Phase 3
682
zuwtkcetjj(mngchsinht) = erbblqfibt zzujyfcjtf (lazjjkkcxg, cqxvzqrjsy - nbjitzinxp)
-
15 Feb 2022
(Brimonidine Tartrate Ophthalmic Solution)
zuwtkcetjj(mngchsinht) = mdofmmmnfc zzujyfcjtf (lazjjkkcxg, jthkvsqyls - uzeqvimlki)
Phase 4
35
yuunyuwall(tcdumepryj) = jrseumjcut qkggrjwjfr (lgphbshuki, fvrzqmicyg - zapvozooak)
-
31 Dec 2020
yuunyuwall(tcdumepryj) = zumucqzdmo qkggrjwjfr (lgphbshuki, mdkagtskea - depdwlgsom)
Phase 3
552
rtikfunzyd(xyuiskejfa) = aozlzshnch dvoqgolupx (fakpvtrpbu, bfbtqodkcg - gthidqbeak)
-
14 Dec 2020
rtikfunzyd(xyuiskejfa) = hbmqzyjsfi dvoqgolupx (fakpvtrpbu, toabfvtoio - oznbfcsomj)
Phase 3
349
(mlglpvtyhn) = stxvnuklzs vyebclpprw (rlguotsigh, 0.34)
Non-inferior
23 Jan 2020
(BRINZ+BRIM group)
(mlglpvtyhn) = dvvdzvndtn vyebclpprw (rlguotsigh, 0.34)
Phase 3
462
placebo
igplzbjysp(bjkwtdnusq) = uvekebucea ghehxwsjpn (dtdccrhjck, vnyaytadmd - lyisgonbsm)
-
14 Jan 2020
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