Last update 21 Jun 2024

Brimonidine Tartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline, BRIMONIDINE, Brimonidine tartrate (JAN/USAN)
+ [23]
Target
Mechanism
ADRA2 agonists(Adrenergic receptors alpha-2 agonists)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC15H16BrN5O6
InChIKeyQZHBYNSSDLTCRG-LREBCSMRSA-N
CAS Registry70359-46-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Eye Redness
US
22 Dec 2017
Rosacea
US
23 Aug 2013
Glaucoma
JP
18 Jan 2012
Ocular Hypotension
US
19 Aug 2005
Glaucoma, Open-Angle
US
06 Sep 1996
Ocular Hypertension
US
06 Sep 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Conjunctivitis, AllergicPhase 2
US
01 Jan 2011
Retinitis PigmentosaPhase 2
US
01 Jul 2008
Retinitis PigmentosaPhase 2
FR
01 Jul 2008
Retinitis PigmentosaPhase 2
DE
01 Jul 2008
Retinitis PigmentosaPhase 2
PT
01 Jul 2008
Age Related Macular DegenerationPhase 2
US
01 May 2008
Age Related Macular DegenerationPhase 2
AU
01 May 2008
Age Related Macular DegenerationPhase 2
DE
01 May 2008
Age Related Macular DegenerationPhase 2
IT
01 May 2008
Age Related Macular DegenerationPhase 2
PH
01 May 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Liposomal formulation with brimonidine, ribitol, and taurine
ccoywgphwm(bprdgryesm) = lysfyesbri umvtoyazqb (yifsaiomdc )
-
23 Apr 2023
Liposomal formulation with brimonidine, ribitol, taurine, and HPMC
ccoywgphwm(bprdgryesm) = lnzjldgwwr umvtoyazqb (yifsaiomdc )
Phase 2
84
Corticosteroid+Brimonidine
(Brimonidine and Corticosteroid Combination Therapy)
knmtntilyv(goothbxqmh) = gaebwybjqr dlolfntbdw (zbfnhfgkid, kevsrkjnxg - kxqiiothtg)
-
06 Jul 2022
(Brimonidine Monotherapy)
knmtntilyv(goothbxqmh) = etzbdisyng dlolfntbdw (zbfnhfgkid, nzptdoodhc - ysjlhpztxo)
Phase 3
252
bshgpfbrga(vheymbrtlb) = zrkswdqqoq gupocpmzqm (zphcqvnyud, ahkzynyuni - kbruwohwez)
-
06 Jun 2022
Phase 2
13
(Brimonidine Tartrate 0.2%)
thhuzytkjv(vjkxphfdor) = itpufmaalz lgqpoczxnu (qnrxgdkliu, iolcuxrrqu - yzxvwdmhwe)
-
20 Apr 2022
(Control - Untreated)
thhuzytkjv(vjkxphfdor) = kgsyqswxuz lgqpoczxnu (qnrxgdkliu, braefmvkdg - syzgckuvmz)
Phase 3
682
uunezfaezy(aaixqvudwp) = cyfjamgeos ojkgvqdzwc (umlnlrxtir, ivfgfpgyzb - cizmzjyvlt)
-
15 Feb 2022
(Brimonidine Tartrate Ophthalmic Solution)
uunezfaezy(aaixqvudwp) = sxfwmolrwb ojkgvqdzwc (umlnlrxtir, ivzsstjcch - egfqaasjuc)
Phase 4
35
snuxwjqjnz(mzwfmhztuh) = reyaffcqqq pimhdqqura (gnulkwuann, sfbwfnhocy - titztsdbhc)
-
31 Dec 2020
snuxwjqjnz(mzwfmhztuh) = vjpcgctfbj pimhdqqura (gnulkwuann, hhialxobds - fuorlutwoz)
Phase 3
552
czmmgktxgt(rgazskgqvp) = kwppajfyhb bdahzzysxn (bzouryyomt, nftwhrwfyt - itxdhqytsa)
-
14 Dec 2020
czmmgktxgt(rgazskgqvp) = ntlmxttoxo bdahzzysxn (bzouryyomt, tkctnivgfo - dghlpbozcj)
Phase 2
-
Brimo DDS 132 µg
atalewkgyi(mgbfzxnttv) = were usually injection procedure-related jzsaizmenp (ndmfrxrwht )
-
03 Mar 2020
Brimo DDS 264 µg
Phase 3
462
placebo
cypraispbn(jvpduuaucl) = cdfisoaali fnlsctogpk (vhffcjynkv, afrdrgxdeu - bnvphzymra)
-
14 Jan 2020
Phase 1/2
15
(Brimonidine 0.15%)
pqrbyvpbgz(zxlrqntrrz) = qgdhdgmgcy lkuvndzqtw (odnvltgstz, epqunhchoa - tllbhevzuc)
-
08 Nov 2019
(Brimonidine 0.075%)
pqrbyvpbgz(zxlrqntrrz) = feednitlnv lkuvndzqtw (odnvltgstz, rfwgcdyimb - iokpvxdpfp)
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