Brimonidine Tartrate

Global review highlights increasing prevalence of noninfectious ocular redness due to digital eye strain, dry eye disease, allergies and environmental exposures LUMIFY redness reliever eye drops (brimonidine tartrate 0.025%) are highlighted as a differentiated OTC option due to its highly selective α2 mechanism, with no tachyphylaxis over 29 days and virtually no rebound redness Review also notes a preservative-free formulation of brimonidine tartrate 0.025% showing comparable efficacy, safety and tolerability; Bausch + Lomb introduced LUMIFY Preservative Free Eye Drops in 2025 VAUGHAN, Ontario--(BUSINESS WIRE)--Bausch + Lomb Corporation (NYSE/TSX: BLCO), a leading global eye health company dedicated to helping people see better to live better, announced today that Ophthalmology and Therapy published a new global narrative review examining the causes, burden and management of noninfectious conjunctival hyperemia (ocular redness). The review highlights the growing global prevalence of ocular redness driven by digital lifestyles, dry eye, contact lens wear, allergies and environmental factors, reinforcing how ocular redness affects both comfort and appearance.1 Developed by clinical experts from nine countries, the publication underscores the aesthetic and psychosocial impact of ocular redness, noting that individuals with red eyes may be perceived as less healthy or more fatigued – a concern amplified by video conferencing and social media, which spotlight facial features, including the eyes and the periocular region. The authors also note that ocular redness frequently presents symptoms such as irritation, dryness, itching or foreign-body sensation, contributing to patient discomfort and reduced quality of life. “Ocular redness is no longer just a clinical concern, it’s a global lifestyle and quality-of-life issue,” said Melissa Toyos, MD, lead author of the review and partner, Toyos Clinic, Nashville, Tenn. “Patients today are seeking effective, safe and aesthetically minded products, which makes understanding the differences in products more important than ever.” Key clinical insights from the paper: Rising prevalence: Noninfectious conjunctival hyperemia is rising worldwide due to digital eye strain, dry eye disease, allergies, contact lens wear and environmental factors Limitations of traditional decongestants: Traditional α1 and mixed α1/α2 decongestants may provide short-term symptom relief but are prone to tachyphylaxis, rebound redness and shorter duration of effect Impact on comfort and appearance: Ocular redness is often accompanied by symptoms such as irritation and dryness, and may adversely affect quality of life due to both discomfort and aesthetic concerns Evidence for brimonidine tartrate 0.025%: Brimonidine tartrate 0.025% (LUMIFY Redness Reliever eye drops), a highly selective α2-adrenergic receptor (AR) agonist, demonstrated effective redness reduction with no tachyphylaxis over 29 days and virtually no rebound redness after discontinuation Aesthetic-driven OTC use: Patients increasingly seek safe OTC redness-relief products for aesthetic reasons, highlighting the importance of selective mechanisms and favorable safety profiles Need for patient education: Global gaps exist in patient awareness and clinical guidance, underscoring the importance of patient education, appropriate OTC product selection and awareness of safety considerations, especially amid increasing global self-treatment and concerns with unsafe or unapproved copycat or counterfeit redness relievers “This publication reinforces the unique, mechanism-based advantages of LUMIFY,” said Mayssa Attar, senior vice president, Pharmaceuticals and Consumer R&D, Bausch + Lomb. “The evidence supporting selective α2-AR agonist mechanism clearly differentiates LUMIFY’s established safety and efficacy profile and reflects our commitment to delivering trusted, science-backed products for consumers.” LUMIFY, formulated with low-dose brimonidine tartrate 0.025%, provides fast, effective redness reduction while avoiding tachyphylaxis and rebound redness associated with traditional decongestants. Its highly selective α2-AR agonist mechanism primarily constricts venules rather than arterioles, contributing to a favorable safety profile, tolerability and efficacy. Clinical evidence across four trials demonstrated no tachyphylaxis over 29 days and virtually no rebound redness upon discontinuation. The review also notes a preservative-free formulation of brimonidine tartrate 0.025%, which demonstrated efficacy, safety and tolerability comparable to the original version with virtually no rebound redness. In 2025, Bausch + Lomb introduced LUMIFY Preservative Free Eye Drops in convenient single-use vials, offering patients an additional brimonidine-based option without preservatives. For more information on LUMIFY and LUMIFY Preservative Free, visit www.lumifyeyes.com. About Ocular Redness Ocular redness, or conjunctival hyperemia, is a common condition that occurs when tiny blood vessels on the surface of the eye become enlarged or irritated, causing the eye to appear red or bloodshot. It can be caused by factors such as digital eye strain, dry eye disease, allergies, contact lens wear and environmental irritants. Mild redness can be accompanied by irritation or dryness and can impact comfort, appearance and confidence, prompting many people to seek over-the-counter relief.2 About LUMIFY Redness Reliever Eye Drops LUMIFY is a redness reliever like no other. With its novel mechanism of action and favorable safety profile, LUMIFY has redefined the category and become an eye care staple – helping eyes look whiter, brighter and more beautiful. It’s the No. 1 eye doctor-recommended redness reliever eye drop brand and holds more than 60% market share. LUMIFY works in one minute and lasts up to eight hours when used as directed. In 2025, Bausch + Lomb introduced LUMIFY Preservative Free Eye Drops in convenient, single-use vials. For more information, visit www.lumifyeyes.com. About Bausch + Lomb Our mission is simple – we help people see better to live better, all over the world. For nearly two centuries we’ve evolved with the changing needs of patients and customers, and our commitment to innovation and improving the standard of care in eye health has never been stronger. From contact lenses to prescription products, over-the-counter options, surgical devices and more, we’re turning bold ideas into better outcomes through passion, perseverance and purpose. Learn more at www.bausch.com and connect with us on Facebook, Instagram, LinkedIn, X and YouTube. References Toyos M, Chan CC, Alio JL, Chong KKL, Pek D, Doan S, Sinjab M, Hosny M, Messmer EM, Giannaccare G. “Global Perspectives on Therapy for Noninfectious Conjunctival Hyperemia: A Narrative Review.” Ophthalmology and Therapy. 2026. https://doi.org/10.1007/s40123-026-01310-7 . Cleveland Clinic. Red Eye: Causes, Treatment & Prevention. 2023. https://my.clevelandclinic.org/health/symptoms/17690-red-eye . ©2026 Bausch + Lomb. LUM.0051.USA.26