Last update 29 Nov 2024

Lurasidone/Cycloserine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cycloserine/lurasidone, NRX-101
Mechanism
5-HT1A receptor agonists(Serotonin 1a (5-HT1a) receptor agonists), 5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists), 5-HT7 receptor antagonists(Serotonin 7 (5-HT7) receptor antagonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationPriority Review (US), Fast Track (US), Qualified Infectious Disease Product (US), Breakthrough Therapy (US)
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Structure

Molecular FormulaC3H6N2O2
InChIKeyDYDCUQKUCUHJBH-UWTATZPHSA-N
CAS Registry68-41-7
View All Structures (2)

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bipolar and Related DisordersPhase 3
US
05 Jun 2023
Bipolar DisorderPhase 3
US
12 May 2022
Depressive DisorderPhase 3
US
01 Dec 2019
Suicidal IdeationPhase 3
US
01 Dec 2019
Complicated urinary tract infectionPhase 2-31 Mar 2024
PyelonephritisPhase 2-31 Mar 2024
Nociceptive PainPhase 2
US
-
Stress Disorders, Post-TraumaticPhase 2
US
-
Chronic PainIND Application
US
30 Aug 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
-
bnkqnmvnda(uiuulcrdne) = NRX-101 and lurasidone both demonstrated > 50% response for treating bipolar depression with no difference seen on primary efficacy endpoint (MADRS) zzaiksxkcy (uhkhoovqqo )
Positive
28 May 2024
Phase 2
-
tkfqcqwxbx(wzofudxxxz) = xzuygyakkr aibkzacozp (qqyyrkarza )
Positive
06 May 2024
tkfqcqwxbx(wzofudxxxz) = geaailypqj aibkzacozp (qqyyrkarza )
Phase 2
22
(Ketamine Followed by NRX-101)
xxdhygxceh(qmmyutonth) = wfwnzsmwbp yuxczcizjr (mfocauujbx, cmnlxmmtmb - wkgbazwjoo)
-
25 May 2021
(Ketamine Followed by Lurasidone)
xxdhygxceh(qmmyutonth) = kqopdbsbni yuxczcizjr (mfocauujbx, uloycvkkhq - dgzkegvusr)
Phase 2
20
hthjrddtxr(hcwjvjwvth) = Overall the drug was well tolerated, with no serious adverse events zzxfujzmxn (mzzyxtcfya )
Positive
30 May 2019
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Approval

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Regulation

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