The company noted that the IL-13-directed monoclonal antibody can now be prescribed routinely to eligible patients aged 12 and above weighing at least 40 kg through the NHS in England and Wales, in line with a commercial agreement which entails a simple discount patient access scheme for the drug.
Ebglyss was cleared to treat atopic dermatitis in the EU and UK last year, based on favourable findings from three Phase III studies: ADvocate 1 and ADvocate 2 evaluating the drug as monotherapy, and ADhere investigating its combination with topical corticosteroids. Results demonstrated early efficacy of Ebglyss at week 16, achieving a 75% reduction in disease extent and severity (EASI-75) in nearly six out of 10 patients.
“The NICE recommendation for lebrikizumab..is testament to the benefits this treatment can bring to patients due to its demonstrated efficacy, with 4-weekly maintenance dosing and an acceptable safety profile,” said Jorgen Damsbo, general manager at Almirall UK. Key opinion leaders interviewed by FirstWord last year said Ebglyss is at least as efficacious as Sanofi and Regeneron's Dupixent (dupilumab), with its monthly dosing being a significant advantage.
The Spanish drugmaker holds European rights to Ebglyss from EliLilly, which acquired the asset through its $1.1-billion takeout of Dermira in 2020. The FDA, however, turned down Lilly’s marketing application for the drug in October last year, citing third-party manufacturing issues.
The content of the article does not represent any opinions of Synapse and its affiliated companies. If there is any copyright infringement or error, please contact us, and we will deal with it within 24 hours.
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.