Using data from the Nurses' Health Study and Health Professionals Follow-Up Study, the authors evaluated individuals with a body mass index (BMI) greater than 25 kg/m2 at least once during a 10-year period (1990 to 1999) to determine how having overweight/obesity impacted cardiovascular risk (heart attack or stroke) between 2000 and 2020. The researchers found that individuals who were exposed to excess weight for a prolonged period of time had an increased risk for heart attack and stroke. In addition, prolonged exposure had a greater impact on heart attack and stroke risk than someone's weight at a single point in time. The increase in risk for heart attack and stroke from the prolonged excess weight was only observed in younger individuals (younger than 50 years for women and younger than 65 years for men). "The key conclusion is that a person's weight at a given point in time is not the final 'sentence' -- one can 'appeal,'" Turchin said. "What matters is what is done about it next. I see this as a glass half-full: even if someone has overweight/obesity at some point in time, they can reduce their risk for heart attack/stroke if they lower their weight over time." The authors evaluated 599 adolescents (average age, 15 years) being prescribed a GLP-1 receptor agonistGLP-1 receptor agonist and found that less than 70 percent of GLP-1 receptor agonists were approved for children with type 2 diabetes and less than 40 percent were approved for weight management. Once a medication was approved, 44 percent of patients treated for obesity did not reach the full treatment dose. "There is more than just sending a GLP-1 receptor agonistGLP-1 receptor agonist prescription when taking care of children with type 2 diabetes and weight management," Castano said. "There are several limitations that are important to highlight: insurance approval, medication titration, medication engagement, as well as side effects." Sriram Machineni, M.D., of the Albert Einstein College of Medicine/Montefiore Medical Center in Bronx, New York, and colleagues found that individuals with no obesity-related medical issues respond to tirzepatide just as well as individuals with two or more medical issues other than type 2 diabetes. The authors evaluated 4,726 individuals from four different clinical trials. The participants either had obesity or overweight, along with an obesity-related medical condition, and 938 also had comorbid type 2 diabetes. The researchers found that individuals who had two or more obesity-related medical issues were older and had a longer duration of obesity than those with fewer obesity-related complications. In addition, BMI was not higher in patients with more obesity-related medical problems. The presence of more obesity-related medical problems did not affect weight loss from the medication tirzepatide. "Providers and patients can look forward to a good weight loss response to tirzepatide whether or not they suffer from other medical problems related to their obesity," Manchineni said. By separating early-life stress into type (limited resources, family conflict, and traumatic events), the investigators found that family conflict was a predictor of increased risk for substance use in both males and females. Limited resources predicted an increased risk for substance use in females, while traumatic events predicted an increased risk in males, specifically for nicotine use.
"Sex moderates the association between early-life stress and substance use initiation by age 13," Donovan said. "Clinicians working with low-resourced or high-conflict families should advise parents to discuss substance use with their children earlier, and provide alternate positive coping mechanisms."
ENDO: Novel Male Contraceptive Gel May Achieve Faster Sperm Suppression
WEDNESDAY, June 12, 2024 -- A novel male contraceptive gel suppresses sperm production faster than other hormone-based methods for male birth control, according to a phase 2 study presented at the annual meeting of the Endocrine Society, held from June 1 to 4 in Boston.
TUESDAY, June 11, 2024 -- Most patients with thyroid eye disease treated with teprotumumab do not require additional treatments nearly two years later, according to a study presented at the annual meeting of the Endocrine Society, held from June 1 to 4 in Boston and simultaneously published online June 2 in Thyroid. ENDO: Early Menopause Tied to Heightened Risk for Breast, Ovarian Cancer
TUESDAY, June 11, 2024 -- Women with early menopause have a two times greater risk for breast cancer and a nearly four times higher risk for ovarian cancer, according to a study presented at the annual meeting of the Endocrine Society, held from June 1 to 4 in Boston. ENDO: Cardiovascular Events Occur Less Often With GLP1-RA, SGLT-2i for T2D, Liver Disease WEDNESDAY, June 5, 2024 -- Crinecerfont results in a greater decrease from baseline in the mean daily glucocorticoid dose among patients with congenital adrenal hyperplasia, according to a study published online June 2 in the New England Journal of Medicine to coincide with the annual meeting of the Endocrine Society, held from June 1 to 4 in Boston. Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.