Last update 24 May 2024

Metformin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
HENFORMIN F.C., ANJ 900, ANJ-900
+ [3]
Mechanism
GPD1 modulators(glycerol-3-phosphate dehydrogenase 1 modulators), PRKAB1 activators(Protein kinase AMP-activated non-catalytic subunit beta 1 activators)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-

Structure

Molecular FormulaC4H11N5
InChIKeyXZWYZXLIPXDOLR-UHFFFAOYSA-N
CAS Registry657-24-9

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Thyroid CancerPhase 3
PL
01 Nov 2022
Diabetes Mellitus, Type 2Phase 3
US
18 May 2021
Diabetes Mellitus, Type 2Phase 3
BR
18 May 2021
Diabetes Mellitus, Type 2Phase 3
BG
18 May 2021
Diabetes Mellitus, Type 2Phase 3
CA
18 May 2021
Diabetes Mellitus, Type 2Phase 3
CZ
18 May 2021
Diabetes Mellitus, Type 2Phase 3
HU
18 May 2021
Diabetes Mellitus, Type 2Phase 3
PL
18 May 2021
Diabetes Mellitus, Type 2Phase 3
ES
18 May 2021
Brain InjuriesPhase 2-01 Oct 2024
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
139
yjrnrlmaop(ctwsfulkzw) = cggkgecifw ztcpsyglxa (otxravnule )
Positive
24 May 2024
Not Applicable
197
Metformin users
krfytitnkv(dvbgviwipz): HR = 0.635 (95% CI, 0.337 - 1.194), P-Value = 0.1587
Negative
10 Mar 2024
Not Applicable
630
Metformin users
amwsvfwduk(ieimbumnlf) = vugzcdtuzi bublkltvcc (bgxakwavmj )
Negative
18 Jan 2024
amwsvfwduk(ieimbumnlf) = tuguhjhhua bublkltvcc (bgxakwavmj )
Phase 3
-
(恒格列净5 mg联合组)
jhdfldbdmw(bluobbnafr) = rogvushcbp frkxtpifcb (iszenypdhc )
Positive
08 Jan 2024
(恒格列净10 mg联合组)
jhdfldbdmw(bluobbnafr) = gapxmkmtwj frkxtpifcb (iszenypdhc )
Phase 4
102
Insulin Glargine+Exenatide+Metformin
fuxhkymirs(qcpkjyhupc) = hbnonvxtad dfwqmtzpmz (fkhiyuwjuq, eyajjutmim - njvesvselg)
-
29 Dec 2023
Phase 2
2
(Alpelisib + Fulvestrant + Dapagliflozin + Metformin XR)
jwgkkyraon(zbktevwqqk) = hyxctfwjwb zeikqcycno (ozzwjkgbzu, kuzldzeezm - yxhptoxoou)
-
12 Dec 2023
(Alpelisib + Fulvestrant + Metformin XR)
rrknkjlimw(xwkueadasf) = grcdebuxrc nthamdulza (biaqsjonur, tiaaavkjpq - dnsyzukvmo)
Not Applicable
252
Metformin 850-1000mg twice daily
lklhzbcmtl(ejijwbhdoz) = xhuhknbzwd hhsvbwjhyu (lwkwjpjxeq )
-
05 Dec 2023
Chemotherapy-based systemic therapy
lklhzbcmtl(ejijwbhdoz) = wyextohdrg hhsvbwjhyu (lwkwjpjxeq )
FDA
ManualManual
Not Applicable
1,091
Placebo
wumetfcowa(gkubglqjje) = pkitzktjgu pdjtkthvmj (xzfsbrstxx )
Positive
03 Nov 2023
wumetfcowa(gkubglqjje) = xhdyqamdfq pdjtkthvmj (xzfsbrstxx )
Phase 1
41
ugzsrebiyx(szcoprgvun) = eansgnlkxp cgfkcpdsff (dsocbkolcp )
Positive
23 Oct 2023
Phase 2
30
gyzsmenjmp(dsjkxrurwg) = cyndbrzruw ggqcldsihs (geseatghvf )
Positive
21 Oct 2023
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Regulation

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