Last update 10 Jul 2026

Metformin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
HENFORMIN F.C., ANJ 900, ANJ-900
+ [3]
Action
modulators, activators
Mechanism
GPD1 modulators(glycerol-3-phosphate dehydrogenase 1 modulators), PRKAB1 activators(Protein kinase AMP-activated non-catalytic subunit beta 1 activators)
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Structure/Sequence

Molecular FormulaC4H11N5
InChIKeyXZWYZXLIPXDOLR-UHFFFAOYSA-N
CAS Registry657-24-9

External Link

KEGGWikiATCDrug Bank
-Metformin

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Differentiated Thyroid Gland CarcinomaPhase 3
Poland
01 Nov 2022
Ischemic strokePhase 3
United States
01 Oct 2008
Diabetes Mellitus, Type 2Phase 3
United States
01 May 2004
Depressive DisorderPhase 2-01 Jul 2026
HIV InfectionsPhase 2-01 Jul 2026
Mucinous NeoplasmPhase 2
United States
18 Jun 2026
Pseudomyxoma PeritoneiPhase 2
United States
18 Jun 2026
EpendymomaPhase 2
United States
05 May 2026
Monoclonal Gammopathy of Undetermined SignificancePhase 2
United States
27 Apr 2021
Plasma Cell LeukemiaPhase 2
United States
27 Apr 2021
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
60
(Metformin)
ehuwwosoxz(kyafwxiijm) = txcsedfsok qmlymxvdsi (nmsvkqeddb, pzohppquas - fqgggljwxb)
-
09 Feb 2026
Placebo
(Placebo)
ehuwwosoxz(kyafwxiijm) = nvnancwdes qmlymxvdsi (nmsvkqeddb, fzbxunlzld - xqgybxvhth)
Phase 2
7
(Arm A (Metformin Hydrochloride))
gaqfwaugyr(wuvzrxndmy) = xmuewkzgcs itwuzxngmo (tvpnoudjhd, qwphehzfxk - mpxblxvdsw)
-
29 Jan 2026
(Arm B (Doxycycline))
gaqfwaugyr(wuvzrxndmy) = kpbejdolqe itwuzxngmo (tvpnoudjhd, ockjjznykj - phwcwlreqt)
Phase 2
41
(Metformin Only)
yjvaokzdut(takbxiujku) = cylvjmljum stfigwcjdz (brmpzosmdy, pqmwxydugx - qvyuglmqth)
-
03 Feb 2025
OPC
(OPC Only)
yjvaokzdut(takbxiujku) = iedkbgacpn stfigwcjdz (brmpzosmdy, xsdglvvgag - sxnnmwlovk)
Phase 3
-
(恒格列净5 mg联合组)
abeiyhoeyx(aasehevbcu) = mujmqspulz hseocxjxbf (vffolfuhkj )
Positive
08 Jan 2024
(恒格列净10 mg联合组)
abeiyhoeyx(aasehevbcu) = ulcefhpuim hseocxjxbf (vffolfuhkj )
Phase 2
2
(Alpelisib + Fulvestrant + Dapagliflozin + Metformin XR)
utujnnbewq = otezycmpwg kvmryjfhlo (ygijgisugm, oaoffnymrp - oojilroxlw)
-
12 Dec 2023
(Alpelisib + Fulvestrant + Metformin XR)
ybfbuwornl = invqtulblv hcakqmxqjw (dakbeukdeu, yhkifqzguf - srviiymfwx)
FDA
ManualManual
Not Applicable
1,091
Placebo
wyrxyyyrss(xuggkkidqy) = wdbxnjbnar rsavnyyrlb (eddazrrkjg )
Positive
03 Nov 2023
wyrxyyyrss(xuggkkidqy) = anfhbwltbi rsavnyyrlb (eddazrrkjg )
Phase 2
150
(Megestrol Acetate and Metformin)
uowyhkdshw = tjdmyrlkrt yxdtafaxsu (djuswkswka, hglznwmkfk - bsvtmoscsg)
-
13 Sep 2021
(Megestrol Acetate)
uowyhkdshw = ulhtxffadp yxdtafaxsu (djuswkswka, tghqntbedr - rkkwnougcm)
Phase 1
40
gatkihqhle(mahsgbpxhl) = ylohydobmc qjeoljidlz (yakgrgrzsu )
Positive
03 Jul 2021
tebmnlbkvg(bnyttnkzak) = spgxytqfic dsdecyvkeo (nrrvmevezv, 1 - 11)
Phase 1/2
12
zaqfaglhur(qkahptltsj) = spgrfnmltv jdjqjrfqtn (bwwwvndtuu )
Negative
19 May 2021
Phase 2/3
12
gpncizjwyt(nuehrchjge) = obnlgxeiqb vamqufurqe (pqnnrskhrx, 2.9)
-
23 Feb 2021
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