Roche is deepening its commitment to neuroscience, agreeing to a licensing deal with Ionis to develop two preclinical RNA medicines for Alzheimer’s and Huntington’s diseases, Ionis said Wednesday.
Per deal terms, Roche is paying $60 million upfront for rights to the undisclosed drugs, and will assume responsibility for developing them once they are ready for human trials. Ionis could receive further payments if clinical, regulatory and commercial milestones for the drugs are met.
Roche has invested heavily in Alzheimer’s drug development, advancing two antibody therapies into Phase 3 testing only to find they didn’t slow disease progression. The Swiss drugmaker has fallen behind rivals Eisai, Biogen and EliLilly, which have benefited from recent clinical development successes.
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Roche and Ionis have worked together for years. The two are currently collaborating on tominersen, a type of drug called an antisense oligonucleotide that blocks the expression of a protein mutated in Huntington’s disease. That drug is in a Phase 2 trial measuring biologic signs of disease as well as patient function.
In Alzheimer’s, Roche was among the early innovators to develop antibody drugs capable of blocking a protein called amyloid that accumulates in the brains of people with the disease. Roche hit clinical setbacks, as did Lilly, Biogen and Eisai.
Roche hasn’t fully ended its anti-amyloid drug work yet, continuing tests of one called crenezumab in people who have an inherited form of Alzheimer’s. It’s also still studying a formulation of the twice-failed drug gantenerumab that’s designed to better reach into the brain.
Other mid-stage assets include two antibody drugs that target another protein implicated in Alzheimer’s disease, called tau. The company recently disclosed Phase 1 data from a drug targeting another protein known as gamma secretase that’s related to amyloid buildup.
Huntington’s disease has proven nearly as difficult as Alzheimer’s to treat, with approved medicines so far only able to reduce involuntary movements. Ionis and Roche are among several companies seeking to help patients by blocking mutant proteins, although their drug tominersen has had setbacks, too.
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